Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

References related to functions published in Others

PMID	Journal	Published Date	Author	Title
9437199	Arterioscler. Thromb. Vasc. Biol.	1997	Tsoukatos DC et al.	Copper-catalyzed oxidation mediates PAF formation in human LDL subspecies. Protective role of PAF:acetylhydrolase in dense LDL.
9157962	Arterioscler. Thromb. Vasc. Biol.	1997	Frostegård J et al.	Platelet-activating factor and oxidized LDL induce immune activation by a common mechanism.
9122237	Proc. Natl. Acad. Sci. U.S.A.	1997	Xia D and Samols D	Transgenic mice expressing rabbit C-reactive protein are resistant to endotoxemia.
9023292	J. Pharmacol. Exp. Ther.	1997	Riera M et al.	Neutrophils accentuate renal cold ischemia-reperfusion injury. Dose-dependent protective effect of a platelet-activating factor receptor antagonist.
9636125	J. Neurophysiol.	1998	Grassi S et al.	Role of platelet-activating factor in long-term potentiation of the rat medial vestibular nuclei.
11510782	Eur. Respir. J.	2001	Feldman C et al.	Vitamin E attenuates the injurious effects of bioactive phospholipids on human ciliated epithelium in vitro.
11937571	J. Immunol.	2002	Silva AR et al.	Monocyte chemoattractant protein-1 and 5-lipoxygenase products recruit leukocytes in response to platelet-activating factor-like lipids in oxidized low-density lipoprotein.
12356842	Invest. Ophthalmol. Vis. Sci.	2002	Beauchamp MH et al.	Platelet-activating factor in vasoobliteration of oxygen-induced retinopathy.
12444147	J. Immunol.	2002	MacKinnon AC et al.	Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents.
10618308	Circulation	2000 Jan 4-11	Sibelius U et al.	Staphylococcal alpha-toxin provokes coronary vasoconstriction and loss in myocardial contractility in perfused rat hearts: role of thromboxane generation.
10946267	J. Immunol.	2000	Zhuang Q et al.	Activation via multiple signaling pathways induces down-regulation of platelet-activating factor receptors on human B lymphocytes.
10898747	Am. J. Physiol. Gastrointest. Liver Physiol.	2000	Parkman HP et al.	The contractile action of platelet-activating factor on gallbladder smooth muscle.
9760298	Circulation	1998	Kinn JW and Bache RJ	Effect of platelet activation on coronary collateral blood flow.
9412509	J. Neurosci.	1998	Bix GJ and Clark GD	Platelet-activating factor receptor stimulation disrupts neuronal migration In vitro.
15280540	Proc. Natl. Acad. Sci. U.S.A.	2004	Llodrá J et al.	Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques.
15138217	Gut	2004	Yang Y et al.	Increased hepatic platelet activating factor (PAF) and PAF receptors in carbon tetrachloride induced liver cirrhosis.
21257713	FASEB J.	2011	Garland RC et al.	Noninvasive molecular imaging reveals role of PAF in leukocyte-endothelial interaction in LPS-induced ocular vascular injury.
18931035	Mol. Pharmacol.	2009	Welch EJ et al.	Opposing effects of platelet-activating factor and lyso-platelet-activating factor on neutrophil and platelet activation.
19773578	Am. J. Physiol. Endocrinol. Metab.	2009	Cheng L et al.	A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.
19603543	J. Clin. Invest.	2009	Camerer E et al.	Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice.
17634444	Biol. Reprod.	2007	Li Y et al.	Direct evidence for the action of phosphatidylinositol (3,4,5)-trisphosphate-mediated signal transduction in the 2-cell mouse embryo.
18339705	Am. J. Physiol. Gastrointest. Liver Physiol.	2008	Claud EC et al.	Platelet-activating factor-induced chloride channel activation is associated with intracellular acidosis and apoptosis of intestinal epithelial cells.
18441203	Am. J. Physiol. Heart Circ. Physiol.	2008	Leary PJ et al.	A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.
15778280	Am. J. Physiol. Heart Circ. Physiol.	2005	Minnear FL et al.	Sphingosine 1-phosphate prevents platelet-activating factor-induced increase in hydraulic conductivity in rat mesenteric venules: pertussis toxin sensitive.
15728511	J. Immunol.	2005	Lin P et al.	Lysophosphatidylcholine modulates neutrophil oxidant production through elevation of cyclic AMP.
15994743	Eur. J. Endocrinol.	2005	Denizot Y et al.	Platelet-activating factor and human thyroid cancer.
16501051	J. Leukoc. Biol.	2006	Flamand N et al.	Inhibition of platelet-activating factor biosynthesis by adenosine and histamine in human neutrophils: involvement of cPLA2alpha and reversal by lyso-PAF.
17135294	Am. J. Physiol., Cell Physiol.	2007	Osborn TM et al.	Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin.
16651419	Cancer Res.	2006	Heon Seo K et al.	Platelet-activating factor induces up-regulation of antiapoptotic factors in a melanoma cell line through nuclear factor-kappaB activation.