phosphatidylinositol-4-phosphate is a lipid of Glycerophospholipids (GP) class. Phosphatidylinositol-4-phosphate is associated with abnormalities such as Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection and Rhinovirus infection. The involved functions are known as Agent, Signal Transduction, Synthesis, Regulation and Process. Phosphatidylinositol-4-phosphate often locates in Membrane, Tissue membrane, Endosomes, Cytoskeleton and Cell membrane. The associated genes with phosphatidylinositol-4-phosphate are Homologous Gene, Homologous Protein, CDC42 gene, Genome and PIK4CB gene. The related lipids are phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, Phosphatidylserines, phosphatidylinositol 3-phosphate and Total cholesterol.
PMID | Journal | Published Date | Author | Title |
---|---|---|---|---|
26972044 | Biochim. Biophys. Acta | 2016 | Yoshida A et al. | Nanoscale analysis reveals agonist-sensitive and heterogeneous pools of phosphatidylinositol 4-phosphate in the plasma membrane. |
25964431 | J. Gen. Physiol. | 2015 | Kim DI et al. | Dynamic phospholipid interaction of β2e subunit regulates the gating of voltage-gated Ca2+ channels. |
25713054 | FASEB J. | 2015 | Lacalle RA et al. | Type I phosphatidylinositol 4-phosphate 5-kinase homo- and heterodimerization determines its membrane localization and activity. |
25692591 | Biophys. J. | 2015 | Lete MG et al. | Histones cause aggregation and fusion of lipid vesicles containing phosphatidylinositol-4-phosphate. |
25670203 | Sci Signal | 2015 | Borbiro I et al. | Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides. |
25525797 | Cell Host Microbe | 2014 | Roulin PS et al. | Rhinovirus uses a phosphatidylinositol 4-phosphate/cholesterol counter-current for the formation of replication compartments at the ER-Golgi interface. |
25224012 | Antimicrob. Agents Chemother. | 2014 | Reghellin V et al. | NS5A inhibitors impair NS5A-phosphatidylinositol 4-kinase IIIα complex formation and cause a decrease of phosphatidylinositol 4-phosphate and cholesterol levels in hepatitis C virus-associated membranes. |
24711504 | J. Cell Biol. | 2014 | Hammond GR et al. | A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi. |
24706697 | Cancer Res. | 2014 | Tokuda E et al. | Phosphatidylinositol 4-phosphate in the Golgi apparatus regulates cell-cell adhesion and invasive cell migration in human breast cancer. |
24672044 | J. Virol. | 2014 | Ishikawa-Sasaki K et al. | A complex comprising phosphatidylinositol 4-kinase IIIβ, ACBD3, and Aichi virus proteins enhances phosphatidylinositol 4-phosphate synthesis and is critical for formation of the viral replication complex. |
23608234 | Prog. Lipid Res. | 2013 | Clayton EL et al. | Mammalian phosphatidylinositol 4-kinases as modulators of membrane trafficking and lipid signaling networks. |
22875974 | J. Virol. | 2012 | Baird NL et al. | Arenavirus infection induces discrete cytosolic structures for RNA replication. |
22722250 | Science | 2012 | Hammond GR et al. | PI4P and PI(4,5)P2 are essential but independent lipid determinants of membrane identity. |
22301157 | J. Virol. | 2012 | Saxena V et al. | Annexin A2 is involved in the formation of hepatitis C virus replication complex on the lipid raft. |
21810903 | FASEB J. | 2011 | Zakharian E et al. | Intracellular ATP supports TRPV6 activity via lipid kinases and the generation of PtdIns(4,5) P₂. |
20643350 | Dev. Cell | 2010 | Yavari A et al. | Role of lipid metabolism in smoothened derepression in hedgehog signaling. |
20375060 | J. Cell. Sci. | 2010 | Wuttke A et al. | Distinct plasma-membrane PtdIns(4)P and PtdIns(4,5)P2 dynamics in secretagogue-stimulated beta-cells. |
19794145 | Am. J. Physiol., Cell Physiol. | 2009 | Yui N et al. | FAPP2 is required for aquaporin-2 apical sorting at trans-Golgi network in polarized MDCK cells. |
19596799 | J. Cell. Sci. | 2009 | Chan MW et al. | FAK, PIP5KIgamma and gelsolin cooperatively mediate force-induced expression of alpha-smooth muscle actin. |
19296914 | Cell. Signal. | 2009 | Luo R et al. | Arf GAP2 is positively regulated by coatomer and cargo. |
18451111 | Genes Dev. | 2008 | Nakamura T et al. | PX-RICS mediates ER-to-Golgi transport of the N-cadherin/beta-catenin complex. |
18299350 | J. Cell Biol. | 2008 | Blagoveshchenskaya A et al. | Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1. |
16103222 | J. Cell Biol. | 2005 | Vieira OV et al. | FAPP2 is involved in the transport of apical cargo in polarized MDCK cells. |
12954081 | Biochem. J. | 2003 | Waugh MG et al. | Identification and characterization of differentially active pools of type IIalpha phosphatidylinositol 4-kinase activity in unstimulated A431 cells. |
2552987 | Biochem. J. | 1989 | Missiaen L et al. | Polyamines and neomycin inhibit the purified plasma-membrane Ca2+ pump by interacting with associated polyphosphoinositides. |
6331389 | Biochem. J. | 1984 | Tooke NE et al. | Ca2+-sensitive phosphatidylinositol 4-phosphate metabolism in a rat beta-cell tumour. |