Zaragozic acid A
Zaragozic acid A is a lipid of Polyketides (PK) class. Zaragozic acid a is associated with abnormalities such as Hypercholesterolemia, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity, Atherosclerosis and Infection. The involved functions are known as Anabolism, Sterol Biosynthesis Pathway, isoprenoid biosynthetic process, Biochemical Pathway and Adverse effects. Zaragozic acid a often locates in Endoplasmic reticulum, membrane, viral nucleocapsid location, Cell surface, Hepatic and Membrane. The associated genes with Zaragozic acid A are DPM1 gene, PMM2 gene, STN gene, SLC6A7 gene and Amyloid beta-Protein Precursor. The related lipids are Sterols, Fatty Acids, Membrane Lipids, farnesoic acid and Unilamellar Vesicles. The related experimental models are Mouse Model.
References related to functions published in Others
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 21632882 | Cardiovasc. Res. | 2011 | Kimura T et al. | p2y5/LPA(6) attenuates LPA(1)-mediated VE-cadherin translocation and cell-cell dissociation through G(12/13) protein-Src-Rap1. |
| 9730906 | Mol. Pharmacol. | 1998 | Kocarek TA et al. | Regulation of rat hepatic cytochrome P450 expression by sterol biosynthesis inhibition: inhibitors of squalene synthase are potent inducers of CYP2B expression in primary cultured rat hepatocytes and rat liver. |
| 10545111 | EMBO J. | 1999 | Gardner RG and Hampton RY | A 'distributed degron' allows regulated entry into the ER degradation pathway. |
| 11390656 | Mol. Cell. Biol. | 2001 | Gardner RG et al. | In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation. |
| 12391282 | Mol. Pharmacol. | 2002 | Kocarek TA and Mercer-Haines NA | Squalestatin 1-inducible expression of rat CYP2B: evidence that an endogenous isoprenoid is an activator of the constitutive androstane receptor. |
| 12506040 | Blood | 2003 | Li HY et al. | Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responses. |
| 10817720 | Antimicrob. Agents Chemother. | 2000 | Kaneshiro ES et al. | Inhibitors of sterol biosynthesis and amphotericin B reduce the viability of pneumocystis carinii f. sp. carinii. |
| 15345508 | Arterioscler. Thromb. Vasc. Biol. | 2004 | Loike JD et al. | Statin inhibition of Fc receptor-mediated phagocytosis by macrophages is modulated by cell activation and cholesterol. |
| 20103534 | J. Cell. Sci. | 2010 | Linetti A et al. | Cholesterol reduction impairs exocytosis of synaptic vesicles. |
| 22649242 | J. Neurosci. | 2012 | Fünfschilling U et al. | Critical time window of neuronal cholesterol synthesis during neurite outgrowth. |
| 26700959 | Drug Metab. Dispos. | 2016 | Pant A and Kocarek TA | Role of Phosphatidic Acid Phosphatase Domain Containing 2 in Squalestatin 1-Mediated Activation of the Constitutive Androstane Receptor in Primary Cultured Rat Hepatocytes. |
| 26055383 | Antimicrob. Agents Chemother. | 2015 | da Silva MF et al. | In Vitro Antimalarial Activity of Different Inhibitors of the Plasmodial Isoprenoid Synthesis Pathway. |
| 25453115 | J. Endocrinol. | 2015 | Zúñiga-Hertz JP et al. | Distinct pathways of cholesterol biosynthesis impact on insulin secretion. |