trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

References related to functions published in Others

PMID	Journal	Published Date	Author	Title
15034064	J. Immunol.	2004	Idzko M et al.	Lysophosphatidic acid induces chemotaxis, oxygen radical production, CD11b up-regulation, Ca2+ mobilization, and actin reorganization in human eosinophils via pertussis toxin-sensitive G proteins.
15716590	J. Lipid Res.	2005	Budnik LT and Brunswig-Spickenheier B	Differential effects of lysolipids on steroid synthesis in cells expressing endogenous LPA2 receptor.
16497989	Arterioscler. Thromb. Vasc. Biol.	2006	Cui MZ et al.	Lysophosphatidic acid induces early growth response gene 1 expression in vascular smooth muscle cells: CRE and SRE mediate the transcription.
22024689	Mol. Cancer Res.	2011	Jia W et al.	MicroRNA-30c-2* expressed in ovarian cancer cells suppresses growth factor-induced cellular proliferation and downregulates the oncogene BCL9.
24443508	J. Immunol.	2014	Knowlden S and Georas SN	The autotaxin-LPA axis emerges as a novel regulator of lymphocyte homing and inflammation.
9407026	Genes Dev.	1997	Sheridan PL et al.	Histone acetyltransferases regulate HIV-1 enhancer activity in vitro.
9430643	EMBO J.	1998	Wong J et al.	Distinct requirements for chromatin assembly in transcriptional repression by thyroid hormone receptor and histone deacetylase.
9501205	Proc. Natl. Acad. Sci. U.S.A.	1998	Richon VM et al.	A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.
10200307	Proc. Natl. Acad. Sci. U.S.A.	1999	Saito A et al.	A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors.
10535926	Proc. Natl. Acad. Sci. U.S.A.	1999	Carmen AA et al.	Yeast HOS3 forms a novel trichostatin A-insensitive homodimer with intrinsic histone deacetylase activity.
10449719	Proc. Natl. Acad. Sci. U.S.A.	1999	Liu Z et al.	Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin.
10233965	J. Virol.	1999	Zhao W et al.	Trichostatin A up-regulates human papillomavirus type 11 upstream regulatory region-E6 promoter activity in undifferentiated primary human keratinocytes.
11171632	Am. J. Physiol. Gastrointest. Liver Physiol.	2001	Wu JT et al.	Transient vs. prolonged histone hyperacetylation: effects on colon cancer cell growth, differentiation, and apoptosis.
11134513	Proc. Natl. Acad. Sci. U.S.A.	2001	Furumai R et al.	Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin.
11238870	J. Virol.	2001	Shestakova E et al.	Inhibition of histone deacetylation induces constitutive derepression of the beta interferon promoter and confers antiviral activity.
11250901	EMBO J.	2001	Muth V et al.	Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription.
11714976	J. Gen. Virol.	2001	Hatama S et al.	Isolation and sequencing of infectious clones of feline foamy virus and a human/feline foamy virus Env chimera.
11454524	Haematologica	2001	Marianna P et al.	Valproic acid, trichostatin and their combination with hemin preferentially enhance gamma-globin gene expression in human erythroid liquid cultures.
11309512	Proc. Natl. Acad. Sci. U.S.A.	2001	Magdinier F and Wolffe AP	Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia.
11369600	Biol. Reprod.	2001	Ma J et al.	Regulation of zygotic gene activation in the preimplantation mouse embryo: global activation and repression of gene expression.
11404352	Genetics	2001	Klar AJ et al.	A histone deacetylation inhibitor and mutant promote colony-type switching of the human pathogen Candida albicans.
11208539	Am. J. Physiol. Gastrointest. Liver Physiol.	2001	Yang H et al.	Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer.
11988486	Circ. Res.	2002	Qiu P and Li L	Histone acetylation and recruitment of serum responsive factor and CREB-binding protein onto SM22 promoter during SM22 gene expression.
12368351	J. Virol.	2002	Quivy V et al.	Synergistic activation of human immunodeficiency virus type 1 promoter activity by NF-kappaB and inhibitors of deacetylases: potential perspectives for the development of therapeutic strategies.
12384361	Antimicrob. Agents Chemother.	2002	Smith WL and Edlind TD	Histone deacetylase inhibitors enhance Candida albicans sensitivity to azoles and related antifungals: correlation with reduction in CDR and ERG upregulation.
12766035	Invest. Ophthalmol. Vis. Sci.	2003	Klisovic DD et al.	Depsipeptide (FR901228) inhibits proliferation and induces apoptosis in primary and metastatic human uveal melanoma cell lines.
12768031	J. Virol.	2003	Génin P et al.	Impairment of interferon-induced IRF-7 gene expression due to inhibition of ISGF3 formation by trichostatin A.
12805238	Circ. Res.	2003	Illi B et al.	Shear stress-mediated chromatin remodeling provides molecular basis for flow-dependent regulation of gene expression.
12799440	Nucleic Acids Res.	2003	Ferguson M et al.	Histone deacetylase inhibition is associated with transcriptional repression of the Hmga2 gene.
12802019	Proc. Natl. Acad. Sci. U.S.A.	2003	Ji Y et al.	A multistep mechanism for the activation of rearrangement in the immune system.
12953060	J. Cell. Sci.	2003	Nakano M et al.	Epigenetic assembly of centromeric chromatin at ectopic alpha-satellite sites on human chromosomes.
12972566	Mol. Biol. Cell	2003	Cimini D et al.	Histone hyperacetylation in mitosis prevents sister chromatid separation and produces chromosome segregation defects.
12748129	Biol. Reprod.	2003	Enright BP et al.	Epigenetic characteristics and development of embryos cloned from donor cells treated by trichostatin A or 5-aza-2'-deoxycytidine.
12692061	Gut	2003	Schauber J et al.	Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways.
12711682	Nucleic Acids Res.	2003	Valenta T et al.	HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells.
12610114	J. Virol.	2003	Kim SY et al.	Glial cell-specific regulation of the JC virus early promoter by histone deacetylase inhibitors.
12455963	Eukaryotic Cell	2002	Duharcourt S and Yao MC	Role of histone deacetylation in developmentally programmed DNA rearrangements in Tetrahymena thermophila.
12481415	Mol. Cancer Ther.	2002	Blagosklonny MV et al.	Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity.
12881486	Proc. Natl. Acad. Sci. U.S.A.	2003	Grisolano JL et al.	An activated receptor tyrosine kinase, TEL/PDGFbetaR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice.
11120829	J. Immunol.	2000	Magner WJ et al.	Activation of MHC class I, II, and CD40 gene expression by histone deacetylase inhibitors.
10899125	EMBO J.	2000	Clayton AL et al.	Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation.
10329635	EMBO J.	1999	O'Neill LP et al.	A developmental switch in H4 acetylation upstream of Xist plays a role in X chromosome inactivation.
12411399	Circ. Res.	2002	Rössig L et al.	Inhibitors of histone deacetylation downregulate the expression of endothelial nitric oxide synthase and compromise endothelial cell function in vasorelaxation and angiogenesis.
15166165	Genetics	2004	Ronai D et al.	The epigenetic stability of the locus control region-deficient IgH locus in mouse hybridoma cells is a clonally varying, heritable feature.
15292402	J. Cell. Sci.	2004	Tóth KF et al.	Trichostatin A-induced histone acetylation causes decondensation of interphase chromatin.
15269190	Drug Metab. Dispos.	2004	Sanderson L et al.	Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.
15218150	Science	2004	Jia S et al.	RNAi-independent heterochromatin nucleation by the stress-activated ATF/CREB family proteins.
15084747	Proc. Natl. Acad. Sci. U.S.A.	2004	Amor DJ et al.	Human centromere repositioning "in progress".
15060035	J. Bacteriol.	2004	Hildmann C et al.	A new amidohydrolase from Bordetella or Alcaligenes strain FB188 with similarities to histone deacetylases.
15142888	Carcinogenesis	2004	Kim YH et al.	Sodium butyrate sensitizes TRAIL-mediated apoptosis by induction of transcription from the DR5 gene promoter through Sp1 sites in colon cancer cells.
15454570	J. Cell. Sci.	2004	Uramoto H et al.	p73 competes with co-activators and recruits histone deacetylase to NF-Y in the repression of PDGF beta-receptor.
20693262	Hum. Mol. Genet.	2010	Heier CR et al.	Arrhythmia and cardiac defects are a feature of spinal muscular atrophy model mice.
20823130	Haematologica	2010	Ji P et al.	Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts.
20682651	Mol. Cancer Ther.	2010	Sonnemann J et al.	Serine proteases in histone deacetylase inhibitor-induced apoptosis.
21705428	Brain	2011	Gaub P et al.	The histone acetyltransferase p300 promotes intrinsic axonal regeneration.
21576354	J. Cell. Sci.	2011	Bouquet F et al.	A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia.
21383005	Mol. Cancer Res.	2011	Fan T et al.	EZH2-dependent suppression of a cellular senescence phenotype in melanoma cells by inhibition of p21/CDKN1A expression.
20870783	Drug Metab. Dispos.	2011	Paterson S et al.	Histone deacetylase inhibitors increase human arylamine N-acetyltransferase-1 expression in human tumor cells.
21224215	Am. J. Physiol. Lung Cell Mol. Physiol.	2011	Mizuno S et al.	Inhibition of histone deacetylase causes emphysema.
21209038	Carcinogenesis	2011	Nandakumar V et al.	(-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells.
19168895	Invest. Ophthalmol. Vis. Sci.	2009	Sharma A et al.	Trichostatin a inhibits corneal haze in vitro and in vivo.
19351759	Clin. Cancer Res.	2009	Vilar E et al.	Gene expression patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway.
19139378	Hypertension	2009	Glenn DJ et al.	Endothelin-stimulated human B-type natriuretic peptide gene expression is mediated by Yin Yang 1 in association with histone deacetylase 2.
19223499	Clin. Cancer Res.	2009	Deng G et al.	Unique methylation pattern of oncostatin m receptor gene in cancers of colorectum and other digestive organs.
19723888	Mol. Cancer Ther.	2009	Alao JP et al.	Inhibition of type I histone deacetylase increases resistance of checkpoint-deficient cells to genotoxic agents through mitotic delay.
19737884	Invest. Ophthalmol. Vis. Sci.	2010	Kashiwagi Y et al.	Trichostatin A-induced TGF-beta type II receptor expression in retinoblastoma cell lines.
19096014	Blood	2009	Hambach L et al.	Hypomethylating drugs convert HA-1-negative solid tumors into targets for stem cell-based immunotherapy.
19531572	Mol. Cancer Res.	2009	Link PA et al.	Distinct roles for histone methyltransferases G9a and GLP in cancer germ-line antigen gene regulation in human cancer cells and murine embryonic stem cells.
19584167	Clin. Cancer Res.	2009	Thiel A et al.	15-hydroxyprostaglandin dehydrogenase is down-regulated in gastric cancer.
19638401	FASEB J.	2009	Chandrasekaran S et al.	Histone deacetylases facilitate sodium/calcium exchanger up-regulation in adult cardiomyocytes.
20375332	Invest. Ophthalmol. Vis. Sci.	2010	Robertson DM et al.	C-terminal cleavage of DeltaNp63alpha is associated with TSA-induced apoptosis in immortalized corneal epithelial cells.
19906951	Am. J. Physiol. Renal Physiol.	2010	Marumo T et al.	Histone deacetylase modulates the proinflammatory and -fibrotic changes in tubulointerstitial injury.
19864643	Blood	2009	Li X et al.	Mta3-NuRD complex is a master regulator for initiation of primitive hematopoiesis in vertebrate embryos.
19808903	Mol. Cancer Res.	2009	Lee JH et al.	Notch signal activates hypoxia pathway through HES1-dependent SRC/signal transducers and activators of transcription 3 pathway.
20643785	Mol. Cancer Ther.	2010	Rahman R et al.	Histone deacetylase inhibition attenuates cell growth with associated telomerase inhibition in high-grade childhood brain tumor cells.
20538901	Am. J. Physiol. Regul. Integr. Comp. Physiol.	2010	Alamdari N et al.	Sepsis and glucocorticoids upregulate p300 and downregulate HDAC6 expression and activity in skeletal muscle.
20547733	Cardiovasc. Res.	2010	Kaichi S et al.	Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice.
20118114	Hum. Reprod.	2010	Lu Y et al.	Trichostatin A, a histone deacetylase inhibitor, reduces lesion growth and hyperalgesia in experimentally induced endometriosis in mice.
20190033	Am. J. Physiol. Lung Cell Mol. Physiol.	2010	Popova AP et al.	Autocrine production of TGF-beta1 promotes myofibroblastic differentiation of neonatal lung mesenchymal stem cells.
20100935	J. Immunol.	2010	Grabiec AM et al.	Histone deacetylase inhibitors suppress inflammatory activation of rheumatoid arthritis patient synovial macrophages and tissue.
16837598	J. Neurosci.	2006	Leng Y and Chuang DM	Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity.
22038994	Clin. Cancer Res.	2012	Landreville S et al.	Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.
21753193	Biol. Reprod.	2011	Bui HT et al.	Histone deacetylase inhibition improves activation of ribosomal RNA genes and embryonic nucleolar reprogramming in cloned mouse embryos.
21771882	J. Cell. Sci.	2011	Watanabe Y and Tanaka M	p62/SQSTM1 in autophagic clearance of a non-ubiquitylated substrate.
17339605	Mol. Cancer Res.	2007	Alimirah F et al.	IFI16 in human prostate cancer.
17374752	J. Gen. Virol.	2007	Hummel M et al.	Transcriptional reactivation of murine cytomegalovirus ie gene expression by 5-aza-2'-deoxycytidine and trichostatin A in latently infected cells despite lack of methylation of the major immediate-early promoter.
17307905	Reproduction	2007	Bui HT et al.	Regulation of chromatin and chromosome morphology by histone H3 modifications in pig oocytes.
17360565	Proc. Natl. Acad. Sci. U.S.A.	2007	Li B et al.	FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression.
17392473	J. Neurosci.	2007	Dompierre JP et al.	Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation.
17371805	J. Pharmacol. Exp. Ther.	2007	Kim HJ et al.	Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action.
17507654	Mol. Biol. Cell	2007	Royo H et al.	Bsr, a nuclear-retained RNA with monoallelic expression.
17582009	Biol. Reprod.	2007	Huang JC et al.	Changes in histone acetylation during postovulatory aging of mouse oocyte.
17267518	Mol. Hum. Reprod.	2007	Nagashima T et al.	Histone acetylation and subcellular localization of chromosomal protein BRD4 during mouse oocyte meiosis and mitosis.
17502362	Ann. Rheum. Dis.	2007	Iliopoulos D et al.	Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention.
17626110	Eur. Respir. J.	2007	Dombrowsky H and Uhlig S	Steroids and histone deacetylase in ventilation-induced gene transcription.
18024558	Plant Physiol.	2008	Tanaka M et al.	The Arabidopsis histone deacetylases HDA6 and HDA19 contribute to the repression of embryonic properties after germination.
18024889	J. Gen. Virol.	2007	Park JJ et al.	Functional interaction of the human cytomegalovirus IE2 protein with histone deacetylase 2 in infected human fibroblasts.
18025290	Mol. Cancer Ther.	2007	Moiseeva EP et al.	Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.
18310117	J. Exp. Biol.	2008	Jiang Y et al.	Homocysteine-induced extracellular superoxide dismutase and its epigenetic mechanisms in monocytes.
18310471	J. Pharmacol. Exp. Ther.	2008	Dong G et al.	Induction of apoptosis in renal tubular cells by histone deacetylase inhibitors, a family of anticancer agents.
18424709	J. Immunol.	2008	Sebastián C et al.	Deacetylase activity is required for STAT5-dependent GM-CSF functional activity in macrophages and differentiation to dendritic cells.
18403638	Mol. Cancer Res.	2008	Ko JM et al.	Monochromosome transfer and microarray analysis identify a critical tumor-suppressive region mapping to chromosome 13q14 and THSD1 in esophageal carcinoma.
15827334	Mol. Cancer Ther.	2005	Strait KA et al.	Histone deacetylase inhibitors induce G2-checkpoint arrest and apoptosis in cisplatinum-resistant ovarian cancer cells associated with overexpression of the Bcl-2-related protein Bad.
15755876	Mol. Cancer Res.	2005	Hu J and Colburn NH	Histone deacetylase inhibition down-regulates cyclin D1 transcription by inhibiting nuclear factor-kappaB/p65 DNA binding.
15615768	Hum. Mol. Genet.	2005	Bottardi S et al.	Onset and inheritance of abnormal epigenetic regulation in hematopoietic cells.
16407370	Hum. Mol. Genet.	2006	Fischer S et al.	Histone acetylation dependent allelic expression imbalance of BAPX1 in patients with the oculo-auriculo-vertebral spectrum.
16339075	Mol. Biol. Cell	2006	Nishiyama A et al.	Brd4 is required for recovery from antimicrotubule drug-induced mitotic arrest: preservation of acetylated chromatin.
14976039	Blood	2004	Milhem M et al.	Modification of hematopoietic stem cell fate by 5aza 2'deoxycytidine and trichostatin A.
16293776	J. Endocrinol.	2005	Lee JH et al.	Interactions with p300 enhance transcriptional activation by the PDZ-domain coactivator Bridge-1.
16227397	Mol. Cancer Ther.	2005	Francia G et al.	Down-regulation of DNA mismatch repair proteins in human and murine tumor spheroids: implications for multicellular resistance to alkylating agents.
16210330	Int. Immunol.	2005	Chou SD et al.	Histone acetylation regulates the cell type specific CIITA promoters, MHC class II expression and antigen presentation in tumor cells.
16234266	Am. J. Physiol. Endocrinol. Metab.	2006	Sato TA and Mitchell MD	Molecular inhibition of histone deacetylation results in major enhancement of the production of IL-1beta in response to LPS.
16237459	EMBO J.	2005	Kasper LH et al.	Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression.
16278460	Eukaryotic Cell	2005	Juranek SA et al.	snRNA and heterochromatin formation are involved in DNA excision during macronuclear development in stichotrichous ciliates.
15486319	Circ. Res.	2004	Alcendor RR et al.	Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes.
15388503	Am. J. Physiol. Heart Circ. Physiol.	2005	Davis FJ et al.	Concurrent opposite effects of trichostatin A, an inhibitor of histone deacetylases, on expression of alpha-MHC and cardiac tubulins: implication for gain in cardiac muscle contractility.
16093438	Mol. Cancer Ther.	2005	García-Morales P et al.	Histone deacetylase inhibitors induced caspase-independent apoptosis in human pancreatic adenocarcinoma cell lines.
14871945	Eukaryotic Cell	2004	García I et al.	Chromatin rearrangements in the prnD-prnB bidirectional promoter: dependence on transcription factors.
15867260	Clin. Cancer Res.	2005	Touma SE et al.	Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.
16000561	Clin. Cancer Res.	2005	Sato N et al.	Epigenetic down-regulation of CDKN1C/p57KIP2 in pancreatic ductal neoplasms identified by gene expression profiling.
16000590	Clin. Cancer Res.	2005	Munshi A et al.	Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity.
15930180	J. Endocrinol.	2005	Gunin AG et al.	Effects of histone deacetylase inhibitors on estradiol-induced proliferation and hyperplasia formation in the mouse uterus.
16002748	Circ. Res.	2005	Kaneda R et al.	Genome-wide screening for target regions of histone deacetylases in cardiomyocytes.
15940285	EMBO Rep.	2005	Taddei A et al.	The effects of histone deacetylase inhibitors on heterochromatin: implications for anticancer therapy?
16973938	Am. J. Physiol. Regul. Integr. Comp. Physiol.	2007	Yang H et al.	Dexamethasone-induced protein degradation in cultured myotubes is p300/HAT dependent.
17000900	J. Leukoc. Biol.	2006	Claus R et al.	Inhibitors of DNA methylation and histone deacetylation independently relieve AML1/ETO-mediated lysozyme repression.
16936308	Mol. Hum. Reprod.	2006	Dokras A et al.	Epigenetic regulation of maspin expression in the human placenta.
16505096	Mol. Cancer Ther.	2006	Ostapkowicz A et al.	Lipid rafts remodeling in estrogen receptor-negative breast cancer is reversed by histone deacetylase inhibitor.
16489177	J. Clin. Pathol.	2006	Song YF et al.	High-frequency promoter hypermethylation of the deleted in liver cancer-1 gene in multiple myeloma.
16513842	Mol. Cancer Res.	2006	Rokhlin OW et al.	Mechanisms of cell death induced by histone deacetylase inhibitors in androgen receptor-positive prostate cancer cells.
16514187	Reproduction	2006	Endo T et al.	Activities of maturation-promoting factor (MPF) and mitogen-activated protein kinase (MAPK) are not required for the global histone deacetylation observed after germinal vesicle breakdown (GVBD) in porcine oocytes.
16980585	Genes Dev.	2006	Li Y et al.	A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity.
17135397	J. Am. Soc. Nephrol.	2007	Yoshikawa M et al.	Inhibition of histone deacetylase activity suppresses epithelial-to-mesenchymal transition induced by TGF-beta1 in human renal epithelial cells.
16531468	Toxicol. Sci.	2006	Vinken M et al.	Trichostatin a enhances gap junctional intercellular communication in primary cultures of adult rat hepatocytes.
16537832	J. Natl. Cancer Inst.	2006	Tada Y et al.	Epigenetic modulation of tumor suppressor CCAAT/enhancer binding protein alpha activity in lung cancer.
16551870	Clin. Cancer Res.	2006	Gagnon JF et al.	Irinotecan inactivation is modulated by epigenetic silencing of UGT1A1 in colon cancer.
16720720	J. Mol. Endocrinol.	2006	Nygård M et al.	Thyroid hormone-mediated negative transcriptional regulation of Necdin expression.
16687489	Mol. Cancer Res.	2006	Wischnewski F et al.	Promoter demethylation and histone acetylation mediate gene expression of MAGE-A1, -A2, -A3, and -A12 in human cancer cells.
16738306	Mol. Biol. Cell	2006	Cabrero JR et al.	Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity.
16174862	Am. J. Physiol. Renal Physiol.	2006	Yu Z and Kone BC	Targeted histone H4 acetylation via phosphoinositide 3-kinase- and p70s6-kinase-dependent pathways inhibits iNOS induction in mesangial cells.
16176989	Proc. Natl. Acad. Sci. U.S.A.	2005	Xu CR et al.	Histone acetylation affects expression of cellular patterning genes in the Arabidopsis root epidermis.
16203797	Clin. Cancer Res.	2005	Fang MZ et al.	Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.
16141407	Arterioscler. Thromb. Vasc. Biol.	2005	Choi JH et al.	Trichostatin A exacerbates atherosclerosis in low density lipoprotein receptor-deficient mice.
17172411	Mol. Cancer Ther.	2006	Lee JH et al.	Histone deacetylase inhibitor enhances 5-fluorouracil cytotoxicity by down-regulating thymidylate synthase in human cancer cells.
17220171	Hum. Mol. Genet.	2007	Ting CH et al.	Stat5 constitutive activation rescues defects in spinal muscular atrophy.
18505930	Mol. Cancer Res.	2008	Pan J et al.	TLS-ERG leukemia fusion protein deregulates cyclin-dependent kinase 1 and blocks terminal differentiation of myeloid progenitor cells.
18483379	Clin. Cancer Res.	2008	Dalgard CL et al.	Evaluation of the in vitro and in vivo antitumor activity of histone deacetylase inhibitors for the therapy of retinoblastoma.
18483381	Clin. Cancer Res.	2008	Egler V et al.	Histone deacetylase inhibition and blockade of the glycolytic pathway synergistically induce glioblastoma cell death.
18445700	Neuro-oncology	2008	Yu C et al.	Mitochondrial Bax translocation partially mediates synergistic cytotoxicity between histone deacetylase inhibitors and proteasome inhibitors in glioma cells.
18451057	Microbiology (Reading, Engl.)	2008	van West P et al.	Internuclear gene silencing in Phytophthora infestans is established through chromatin remodelling.
21954451	Physiol. Genomics	2011	Majumdar G et al.	Panhistone deacetylase inhibitors inhibit proinflammatory signaling pathways to ameliorate interleukin-18-induced cardiac hypertrophy.
21957129	FASEB J.	2012	Icardi L et al.	Opposed regulation of type I IFN-induced STAT3 and ISGF3 transcriptional activities by histone deacetylases (HDACS) 1 and 2.
22271820	J. Pharmacol. Exp. Ther.	2012	Zhang L et al.	Inhibition of histone deacetylases preserves myocardial performance and prevents cardiac remodeling through stimulation of endogenous angiomyogenesis.
22955928	Blood	2012	Sadoul K et al.	HDAC6 controls the kinetics of platelet activation.
22198505	Cardiovasc. Res.	2012	Becker JR et al.	In vivo natriuretic peptide reporter assay identifies chemical modifiers of hypertrophic cardiomyopathy signalling.
22723015	Hum. Mol. Genet.	2012	Balmer NV et al.	Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome.
22771823	Eukaryotic Cell	2012	Tong K et al.	Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing.
22752410	Hum. Mol. Genet.	2012	Brose RD et al.	Activation of the stress proteome as a mechanism for small molecule therapeutics.
22693257	J. Lipid Res.	2012	Nunes MJ et al.	Okadaic acid inhibits the trichostatin A-mediated increase of human CYP46A1 neuronal expression in a ERK1/2-Sp3-dependent pathway.
23814181	Mutagenesis	2013	Keuser B et al.	Influences of histone deacetylase inhibitors and resveratrol on DNA repair and chromatin compaction.
23284002	Mol. Pharmacol.	2013	Yang L et al.	Trichostatin A inhibits transforming growth factor-β-induced reactive oxygen species accumulation and myofibroblast differentiation via enhanced NF-E2-related factor 2-antioxidant response element signaling.
23236151	Proc. Natl. Acad. Sci. U.S.A.	2012	McCullough SD et al.	Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes.
23318799	Antimicrob. Agents Chemother.	2013	Wilson DW et al.	Defining the timing of action of antimalarial drugs against Plasmodium falciparum.
23365234	J. Neurosci.	2013	Dagnas M et al.	HDAC inhibition facilitates the switch between memory systems in young but not aged mice.
23371947	Plant Cell	2013	Wang Z et al.	Arabidopsis paired amphipathic helix proteins SNL1 and SNL2 redundantly regulate primary seed dormancy via abscisic acid-ethylene antagonism mediated by histone deacetylation.
23188729	Invest. Ophthalmol. Vis. Sci.	2013	Li H et al.	Epigenetic regulation of CXCR4 expression by the ocular microenvironment.
23104973	Reproduction	2013	Oliveira CS et al.	HDAC inhibition decreases XIST expression on female IVP bovine blastocysts.
23166393	Philos. Trans. R. Soc. Lond., B, Biol. Sci.	2013	Ogura A et al.	Recent advancements in cloning by somatic cell nuclear transfer.
23538711	FASEB J.	2013	Chambliss AB et al.	Simultaneously defining cell phenotypes, cell cycle, and chromatin modifications at single-cell resolution.
23729439	J. Immunol.	2013	Gao B et al.	Inhibition of histone deacetylase activity suppresses IFN-γ induction of tripartite motif 22 via CHIP-mediated proteasomal degradation of IRF-1.
24227836	J. Virol.	2014	Shin HJ et al.	Histone deacetylase classes I and II regulate Kaposi's sarcoma-associated herpesvirus reactivation.
24307736	J. Immunol.	2014	Serrat N et al.	The response of secondary genes to lipopolysaccharides in macrophages depends on histone deacetylase and phosphorylation of C/EBPβ.