Epothilone D
Epothilone d is a lipid of Polyketides (PK) class. Epothilone d is associated with abnormalities such as Tauopathies, Neutropenia, Neuropathy and Hematological Disease. The involved functions are known as Mutation, Apoptosis, Mitotic arrest, Cell Growth and Anabolism. Epothilone d often locates in Cytoskeleton, Axon, Cell Wall, Chromosomes and Spindle. The associated genes with epothilone D are SLC33A1 gene, Chromatin, GTF2I gene and HEXA gene.
References related to functions published in Others
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 12183227 | Antimicrob. Agents Chemother. | 2002 | Julien B and Shah S | Heterologous expression of epothilone biosynthetic genes in Myxococcus xanthus. |
| 12933799 | J. Biol. Chem. | 2003 | Nagano S et al. | Crystal structures of epothilone D-bound, epothilone B-bound, and substrate-free forms of cytochrome P450epoK. |
| 17938270 | Mol. Cancer Ther. | 2007 | Lee SH et al. | Epothilones induce human colon cancer SW620 cell apoptosis via the tubulin polymerization independent activation of the nuclear factor-kappaB/IkappaB kinase signal pathway. |
| 15967777 | J. Exp. Bot. | 2005 | Hause G et al. | Epothilone D affects cell cycle and microtubular pattern in plant cells. |
| 26772969 | Neuropharmacology | 2016 | Penazzi L et al. | Aβ-mediated spine changes in the hippocampus are microtubule-dependent and can be reversed by a subnanomolar concentration of the microtubule-stabilizing agent epothilone D. |