Tylosin

Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.

References related to functions published in Others

PMID	Journal	Published Date	Author	Title
9791136	J. Bacteriol.	1998	Oh TG et al.	Induction of ermAMR from a clinical strain of Enterococcus faecalis by 16-membered-ring macrolide antibiotics.
11353804	Mol. Pharmacol.	2001	Dinos GP et al.	Insights into the mechanism of azithromycin interaction with an Escherichia coli functional ribosomal complex.
12417742	Proc. Natl. Acad. Sci. U.S.A.	2002	Liu M and Douthwaite S	Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy.
18079110	J. Biol. Chem.	2008	Petropoulos AD et al.	Stepwise binding of tylosin and erythromycin to Escherichia coli ribosomes, characterized by kinetic and footprinting analysis.
15795375	Proc. Natl. Acad. Sci. U.S.A.	2005	Pfister P et al.	23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A-->G.
16873579	Mol. Pharmacol.	2006	Karahalios P et al.	On the mechanism of action of 9-O-arylalkyloxime derivatives of 6-O-mycaminosyltylonolide, a new class of 16-membered macrolide antibiotics.
17085767	J. Antimicrob. Chemother.	2007	Lüthje P and Schwarz S	Molecular analysis of constitutively expressed erm(C) genes selected in vitro in the presence of the non-inducers pirlimycin, spiramycin and tylosin.
23666328	Appl. Environ. Microbiol.	2013	Amachawadi RG et al.	Occurrence of the transferable copper resistance gene tcrB among fecal enterococci of U.S. feedlot cattle fed copper-supplemented diets.
23928021	J. Antimicrob. Chemother.	2014	Buß M et al.	Quality control ranges for tylosin 30 μg and 15 μg discs applicable to Staphylococcus aureus ATCC(R) 25923.
15017283	J. Med. Microbiol.	2004	Karlsson M et al.	Further characterization of porcine Brachyspira hyodysenteriae isolates with decreased susceptibility to tiamulin.
28107883	Prev. Vet. Med.	2017	Weber NR et al.	Batch medication of intestinal infections in nursery pigs-A randomised clinical trial on the efficacy of treatment strategy, type of antibiotic and bacterial load on average daily weight gain.