clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

References related to functions published in Others

PMID	Journal	Published Date	Author	Title
9492675	BMJ	1998	Hermon-Taylor J et al.	Mycobacterium paratuberculosis cervical lymphadenitis, followed five years later by terminal ileitis similar to Crohn's disease.
9301496	Gut	1997	Bardhan KD et al.	Ranitidine bismuth citrate with clarithromycin for the treatment of duodenal ulcer.
9152603	Drug Metab. Dispos.	1997	Rodrigues AD et al.	Oxidative metabolism of clarithromycin in the presence of human liver microsomes. Major role for the cytochrome P4503A (CYP3A) subfamily.
10391696	Blood	1999	Stewart AK et al.	Lack of response to short-term use of clarithromycin (BIAXIN) in multiple myeloma.
10075942	Gut	1999	Owen RJ	Helicobacter pylori resists arrest.
10075951	Gut	1999	Marais A et al.	Direct detection of Helicobacter pylori resistance to macrolides by a polymerase chain reaction/DNA enzyme immunoassay in gastric biopsy specimens.
10486356	Gut	1999	Matsuoka M et al.	Simultaneous colonisation of Helicobacter pylori with and without mutations in the 23S rRNA gene in patients with no history of clarithromycin exposure.
10525003	Clin. Infect. Dis.	1999	Baylor P and Williams K	Interstitial nephritis, thrombocytopenia, hepatitis, and elevated serum amylase levels in a patient receiving clarithromycin therapy.
10548572	Clin. Diagn. Lab. Immunol.	1999	Woo PC et al.	Antibiotics modulate vaccine-induced humoral immune response.
9863474	Gut	1998	Maeda S et al.	Helicobacter pylori specific nested PCR assay for the detection of 23S rRNA mutation associated with clarithromycin resistance.
11238960	Microbiology (Reading, Engl.)	2001	Cangelosi GA et al.	Phenotypic consequences of red-white colony type variation in Mycobacterium avium.
11717398	Proc. Natl. Acad. Sci. U.S.A.	2001	Björkholm B et al.	Mutation frequency and biological cost of antibiotic resistance in Helicobacter pylori.
11486298	Clin. Infect. Dis.	2001	Maniu CV et al.	Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.
11477184	Nephrol. Dial. Transplant.	2001	Verhelst D et al.	Purple-blue subcutaneous nodules after renal transplantation: not always Kaposi sarcoma.
11839700	Gut	2002	Owen RJ	Molecular testing for antibiotic resistance in Helicobacter pylori.
11691898	J R Soc Med	2001	Dandekar SS and Laidlaw DA	Suprachoroidal haemorrhage after addition of clarithromycin to warfarin.
11328845	J. Clin. Pathol.	2001	Warburton-Timms VJ and McNulty CA	Role of screening agar plates for in vitro susceptibility testing of Helicobacter pylori in a routine laboratory setting.
11408369	Drug Metab. Dispos.	2001	Bruce MA et al.	In vivo effect of clarithromycin on multiple cytochrome P450s.
12124305	Drug Metab. Dispos.	2002	Williams JA et al.	Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7.
11927522	Circulation	2002	Sinisalo J et al.	Effect of 3 months of antimicrobial treatment with clarithromycin in acute non-q-wave coronary syndrome.
12032331	Proc. Natl. Acad. Sci. U.S.A.	2002	Fahey JW et al.	Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors.
12065733	J. Pharmacol. Exp. Ther.	2002	Volberg WA et al.	Blockade of human cardiac potassium channel human ether-a-go-go-related gene (HERG) by macrolide antibiotics.
12235069	Gut	2002	Sherwood PV et al.	Impact of acid secretion, gastritis, and mucus thickness on gastric transfer of antibiotics in rats.
12631656	Gut	2003	Wang WH et al.	Aspirin inhibits the growth of Helicobacter pylori and enhances its susceptibility to antimicrobial agents.
12818892	Am. J. Physiol. Lung Cell Mol. Physiol.	2003	Kaneko Y et al.	Clarithromycin inhibits overproduction of muc5ac core protein in murine model of diffuse panbronchiolitis.
13130398	Clin. Infect. Dis.	2003	Wong WM et al.	Effects of primary metronidazole and clarithromycin resistance to Helicobacter pylori on omeprazole, metronidazole, and clarithromycin triple-therapy regimen in a region with high rates of metronidazole resistance.
10600812	Am. J. Physiol.	1999	Feldman M et al.	Influence of H. pylori infection on meal-stimulated gastric acid secretion and gastroesophageal acid reflux.
10762562	J. Infect. Dis.	2000	Benson CA et al.	Clarithromycin or rifabutin alone or in combination for primary prophylaxis of Mycobacterium avium complex disease in patients with AIDS: A randomized, double-blind, placebo-controlled trial. The AIDS Clinical Trials Group 196/Terry Beirn Community Programs for Clinical Research on AIDS 009 Protocol Team.
10764702	Gut	2000	Trebesius K et al.	Rapid and specific detection of Helicobacter pylori macrolide resistance in gastric tissue by fluorescent in situ hybridisation.
11063500	Clin. Diagn. Lab. Immunol.	2000	Chow LW et al.	Clarithromycin attenuates mastectomy-induced acute inflammatory response.
10942753	Circulation	2000	Shivkumar K	Images in cardiovascular medicine. Labile repolarization from "cell to bedside".
10950845	Drug Metab. Dispos.	2000	Mayhew BS et al.	An in vitro model for predicting in vivo inhibition of cytochrome P450 3A4 by metabolic intermediate complex formation.
10671330	Clin. Infect. Dis.	2000	Griffith DE et al.	Early results (at 6 months) with intermittent clarithromycin-including regimens for lung disease due to Mycobacterium avium complex.
11872875	Sex Transm Infect	2002	Colebunders R and Florence E	Neuropsychiatric reaction induced by clarithromycin.
14557961	Clin. Infect. Dis.	2003	Griffith DE et al.	Thrice-weekly clarithromycin-containing regimen for treatment of Mycobacterium kansasii lung disease: results of a preliminary study.
14557969	Clin. Infect. Dis.	2003	Benson CA et al.	A prospective, randomized trial examining the efficacy and safety of clarithromycin in combination with ethambutol, rifabutin, or both for the treatment of disseminated Mycobacterium avium complex disease in persons with acquired immunodeficiency syndrome.
15340029	J R Soc Med	2004	Awotesu O et al.	Uveitis in a patient receiving rifabutin for Crohn's disease.
15342952	Toxicol. Sci.	2005	Sawada H et al.	A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system.
15176685	Eur. Respir. J.	2004	Kostadima E et al.	Clarithromycin reduces the severity of bronchial hyperresponsiveness in patients with asthma.
15096549	J. Med. Microbiol.	2004	Kobayashi I et al.	Micro-broth dilution method with air-dried microplate for determining MICs of clarithromycin and amoxycillin for Helicobacter pylori isolates.
21690264	Drug Metab. Dispos.	2011	Peters J et al.	Oral absorption of clarithromycin is nearly abolished by chronic comedication of rifampicin in foals.
21395697	FEMS Immunol. Med. Microbiol.	2011	Hirao S et al.	Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.
21288841	Clin. Infect. Dis.	2011	Lindeboom JA	Conservative wait-and-see therapy versus antibiotic treatment for nontuberculous mycobacterial cervicofacial lymphadenitis in children.
19884323	Drug Metab. Dispos.	2010	Quinney SK et al.	Physiologically based pharmacokinetic model of mechanism-based inhibition of CYP3A by clarithromycin.
19814608	Clin. Infect. Dis.	2009	van Dissel JT and Kuijper EJ	Rapidly growing mycobacteria: emerging pathogens in cosmetic procedures of the skin.
20040578	J. Pharmacol. Exp. Ther.	2010	Yamaya M et al.	Clarithromycin inhibits type a seasonal influenza virus infection in human airway epithelial cells.
15150334	J. Med. Microbiol.	2004	Cameron EA et al.	Helicobacter pylori: antibiotic resistance and eradication rates in Suffolk, UK, 1991-2001.
20847136	Drug Metab. Dispos.	2010	Brown HS et al.	Comparative use of isolated hepatocytes and hepatic microsomes for cytochrome P450 inhibition studies: transporter-enzyme interplay.
22123897	Pediatrics	2011	Ozdemir R et al.	Clarithromycin in preventing bronchopulmonary dysplasia in Ureaplasma urealyticum-positive preterm infants.
18541779	Am. J. Trop. Med. Hyg.	2008	Lee N et al.	Risk factors associated with life-threatening rickettsial infections.
17893176	J. Med. Microbiol.	2007	Moder KA et al.	Rapid screening of clarithromycin resistance in Helicobacter pylori by pyrosequencing.
17989313	Blood	2008	Niesvizky R et al.	BiRD (Biaxin [clarithromycin]/Revlimid [lenalidomide]/dexamethasone) combination therapy results in high complete- and overall-response rates in treatment-naive symptomatic multiple myeloma.
18158394	Am. J. Crit. Care	2008	Buchanan Keller K and Lemberg L	Torsade.
18422455	J. Infect. Dis.	2008	Bermudez LE et al.	The efficacy of clarithromycin and the bicyclolide EDP-420 against Mycobacterium avium in a mouse model of pulmonary infection.
15572528	Eur. Respir. J.	2004	Miravitlles M and Torres A	Antibiotics in exacerbations of COPD: lessons from the past.
15572537	Eur. Respir. J.	2004	Lode H et al.	Levofloxacin versus clarithromycin in COPD exacerbation: focus on exacerbation-free interval.
16339220	BMJ	2006	Jespersen CM et al.	Randomised placebo controlled multicentre trial to assess short term clarithromycin for patients with stable coronary heart disease: CLARICOR trial.
16272330	J. Immunol.	2005	Tomioka H et al.	Combined effects of ATP on the therapeutic efficacy of antimicrobial drug regimens against Mycobacterium avium complex infection in mice and roles of cytosolic phospholipase A2-dependent mechanisms in the ATP-mediated potentiation of antimycobacterial host resistance.
16221754	Drug Metab. Dispos.	2006	Gurley BJ et al.	Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans.
15459155	Eur. Respir. J.	2004	Currie GP and Lee DK	Methacholine and macrolides.
15496391	J. Med. Microbiol.	2004	Gerrits MM et al.	Role of the rdxA and frxA genes in oxygen-dependent metronidazole resistance of Helicobacter pylori.
15713617	J. Med. Microbiol.	2005	Tanaka J et al.	Influence of antimicrobial treatment for Helicobacter pylori infection on the intestinal microflora in Japanese macaques.
15888466	J. Med. Microbiol.	2005	Elviss NC et al.	Helicobacter pylori antibiotic-resistance patterns and risk factors in adult dyspeptic patients from ethnically diverse populations in central and south London during 2000.
15866212	FEMS Immunol. Med. Microbiol.	2005	Park JY et al.	Macrolide-affected Toll-like receptor 4 expression from Helicobacter pylori-infected monocytes does not modify interleukin-8 production.
15976341	J. Clin. Pathol.	2005	Takemura Y et al.	Antibiotic selection patterns in acutely febrile new outpatients with or without immediate testing for C reactive protein and leucocyte count.
16007523	Clin. Infect. Dis.	2005	Hung IF et al.	Fatal interaction between clarithromycin and colchicine in patients with renal insufficiency: a retrospective study.
17050564	Eur. Respir. J.	2007	Tahan F et al.	Clarithromycin in the treatment of RSV bronchiolitis: a double-blind, randomised, placebo-controlled trial.
16946100	Eur. Respir. J.	2006	Vicente de Vera C et al.	Delirium induced by clarithromycin in a patient with community-acquired pneumonia.
16687592	J. Med. Microbiol.	2006	Kobayashi I et al.	Helicobacter pylori isolated from patients who later failed H. pylori eradication triple therapy readily develop resistance to clarithromycin.
17244808	J. Med. Microbiol.	2007	Falkinham JO	Growth in catheter biofilms and antibiotic resistance of Mycobacterium avium.
16603633	Gut	2006	Koletzko S et al.	Prospective multicentre study on antibiotic resistance of Helicobacter pylori strains obtained from children living in Europe.
18444850	Clin. Infect. Dis.	2008	Giamarellos-Bourboulis EJ et al.	Effect of clarithromycin in patients with sepsis and ventilator-associated pneumonia.
18650552	J. Dent. Res.	2008	Chou CH and Walters JD	Clarithromycin transport by gingival fibroblasts and epithelial cells.
18717637	J. Infect. Dis.	2008	Tagliabue C et al.	The impact of steroids given with macrolide therapy on experimental Mycoplasma pneumoniae respiratory infection.
22166485	Toxicol. Sci.	2012	Lin Z and Will Y	Evaluation of drugs with specific organ toxicities in organ-specific cell lines.
22763637	Clin. Microbiol. Rev.	2012	Brown-Elliott BA et al.	Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria.
22896605	J. Virol.	2012	Takahashi E et al.	Oral clarithromycin enhances airway immunoglobulin A (IgA) immunity through induction of IgA class switching recombination and B-cell-activating factor of the tumor necrosis factor family molecule on mucosal dendritic cells in mice infected with influenza A virus.
23836576	Am. J. Trop. Med. Hyg.	2013	de Zeeuw J et al.	Serum levels of neopterin during antimicrobial treatment for Mycobacterium ulcerans infection.
23801607	J. Infect. Dis.	2013	Lee HJ et al.	Eradication of Helicobacter pylori according to 23S ribosomal RNA point mutations associated with clarithromycin resistance.
23525864	BMJ	2013	Schembri S et al.	Cardiovascular events after clarithromycin use in lower respiratory tract infections: analysis of two prospective cohort studies.
23743566	Clin. Cancer Res.	2013	Semino-Mora C et al.	Antibiotic treatment decreases microbial burden associated with pseudomyxoma peritonei and affects β-catenin distribution.