MAYTANSINE

MAYTANSINE is a lipid of Polyketides (PK) class. Maytansine is associated with abnormalities such as Myelosuppression and BOSLEY-SALIH-ALORAINY SYNDROME. The involved functions are known as Mutation, Agent, Polymerization, Cell Cycle Arrest and Drug Kinetics. Maytansine often locates in Cytoplasm, Hepatic, Lysosomes, Cell surface and Microtubules. The associated genes with MAYTANSINE are ABCB1 gene, HM13 gene, CNN1 gene, CYP2C8 gene and CYP2D6 gene. The related lipids are Valerates. The related experimental models are Xenograft Model.

References related to functions published in Others

PMID	Journal	Published Date	Author	Title
12060743	Proc. Natl. Acad. Sci. U.S.A.	2002	Yu TW et al.	The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum.
14634038	J. Pharmacol. Exp. Ther.	2004	Xie H et al.	Pharmacokinetics and biodistribution of the antitumor immunoconjugate, cantuzumab mertansine (huC242-DM1), and its two components in mice.
15292058	Blood	2004	Tassone P et al.	Cytotoxic activity of the maytansinoid immunoconjugate B-B4-DM1 against CD138+ multiple myeloma cells.
22753910	J. Clin. Oncol.	2012	Younes A et al.	Phase I multidose-escalation study of the anti-CD19 maytansinoid immunoconjugate SAR3419 administered by intravenous infusion every 3 weeks to patients with relapsed/refractory B-cell lymphoma.
26963132	Curr. Opin. Immunol.	2016	de Goeij BE and Lambert JM	New developments for antibody-drug conjugate-based therapeutic approaches.
25114240	Proc. Natl. Acad. Sci. U.S.A.	2014	Prota AE et al.	A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs.