Epothilone B

Epothilone B is a lipid of Polyketides (PK) class. Epothilone b is associated with abnormalities such as Myelosuppression, Measurable Disease, Neuropathy, Neutropenia and Thrombocytopenia. The involved functions are known as Cell Cycle Arrest, Apoptosis, Signal Transduction, Cytokinesis and Caspase Activation. Epothilone b often locates in Mitochondria, Cytoplasmic matrix, Microtubules, Spindle and Protoplasm. The associated genes with Epothilone B are TNFSF10 gene, DIABLO gene, FADD gene, BCL2 gene and BCL2L1 gene. The related lipids are Promega and Phosphatidylserines. The related experimental models are Xenograft Model and Mouse Model.

References related to functions published in Others

PMID	Journal	Published Date	Author	Title
9202030	J. Biol. Chem.	1997	Giannakakou P et al.	Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization.
10200249	Proc. Natl. Acad. Sci. U.S.A.	1999	Ojima I et al.	A common pharmacophore for cytotoxic natural products that stabilize microtubules.
11964312	Blood	2002	Guo F et al.	Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis.
15367426	Blood	2005	Lin B et al.	Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo.
21245138	J. Biol. Chem.	2011	Khrapunovich-Baine M et al.	Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation.
19179341	Protein Eng. Des. Sel.	2009	Nayeem A et al.	Engineering enzymes for improved catalytic efficiency: a computational study of site mutagenesis in epothilone-B hydroxylase.
19087985	Ann. Oncol.	2009	Hussain A et al.	Phase II trial of weekly patupilone in patients with castration-resistant prostate cancer.
19451434	J. Clin. Oncol.	2009	Ten Bokkel Huinink WW et al.	Safety and efficacy of patupilone in patients with advanced ovarian, primary fallopian, or primary peritoneal cancer: a phase I, open-label, dose-escalation study.
20008956	J. Pharmacol. Exp. Ther.	2010	Lazo JS et al.	Identifying a resistance determinant for the antimitotic natural products disorazole C1 and A1.
21743064	Neuro-oncology	2011	Oehler C et al.	The microtubule stabilizer patupilone (epothilone B) is a potent radiosensitizer in medulloblastoma cells.
17289837	J. Pharmacol. Exp. Ther.	2007	Lim Y et al.	Epothilone B inhibits neointimal formation after rat carotid injury through the regulation of cell cycle-related proteins.
17606970	J. Clin. Oncol.	2007	Gianni L	Ixabepilone and the narrow path to developing new cytotoxic drugs.
17606971	J. Clin. Oncol.	2007	Denduluri N et al.	Phase II trial of ixabepilone, an epothilone B analog, in patients with metastatic breast cancer previously untreated with taxanes.
18073274	Mol. Pharmacol.	2008	Raccor BS et al.	Cell-based and biochemical structure-activity analyses of analogs of the microtubule stabilizer dictyostatin.
16301595	J. Clin. Oncol.	2005	Rubin EH et al.	Phase I dose-finding study of weekly single-agent patupilone in patients with advanced solid tumors.
18593821	Mol. Pharmacol.	2008	Khawaja NR et al.	Patupilone-induced apoptosis is mediated by mitochondrial reactive oxygen species through Bim relocalization to mitochondria.
21953449	J. Biol. Chem.	2011	Lin PC et al.	Collapsin response mediator proteins (CRMPs) are a new class of microtubule-associated protein (MAP) that selectively interacts with assembled microtubules via a taxol-sensitive binding interaction.
22987083	J. Clin. Oncol.	2012	Colombo N et al.	Randomized, open-label, phase III study comparing patupilone (EPO906) with pegylated liposomal doxorubicin in platinum-refractory or -resistant patients with recurrent epithelial ovarian, primary fallopian tube, or primary peritoneal cancer.
26883566	Exp. Neurol.	2016	Pittman SK et al.	Nerve growth factor alters microtubule targeting agent-induced neurotransmitter release but not MTA-induced neurite retraction in sensory neurons.
25765066	Science	2015	Ruschel J et al.	Axonal regeneration. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury.