rotenone is a lipid of Polyketides (PK) class. Rotenone is associated with abnormalities such as Parkinson Disease, MYOPATHY, DISTAL, WITH ANTERIOR TIBIAL ONSET, Neurodegenerative Disorders, Septicemia and Respiratory Failure. The involved functions are known as Phosphorylation, Process, Cell Death, proteasome activity and Apoptosis. Rotenone often locates in Protoplasm, Presynaptic Terminals, Neurites, NADH dehydrogenase complex and Mitochondria. The associated genes with rotenone are DNAJB9 gene, EIF2S3 gene, Candidate Disease Gene, G-substrate and ERN1 gene. The related lipids are Lipopolysaccharides, Membrane Lipids, Phosphatidylserines, Fatty Acids and Cardiolipins. The related experimental models are Knock-out, Mouse Model, Disease model and Rodent Model.
PMID | Journal | Published Date | Author | Title |
---|---|---|---|---|
9037024 | Proc. Natl. Acad. Sci. U.S.A. | 1997 | Villani G and Attardi G | In vivo control of respiration by cytochrome c oxidase in wild-type and mitochondrial DNA mutation-carrying human cells. |
9495873 | J. Pharmacol. Exp. Ther. | 1998 | Brambilla L et al. | Electron transport-mediated wasteful consumption of NADH promotes the lethal response of U937 cells to tert-butylhydroperoxide. |
9520374 | Proc. Natl. Acad. Sci. U.S.A. | 1998 | Fang N and Casida JE | Anticancer action of cubé insecticide: correlation for rotenoid constituents between inhibition of NADH:ubiquinone oxidoreductase and induced ornithine decarboxylase activities. |
9688604 | Am. J. Physiol. | 1998 | Jezek P and Borecký J | Mitochondrial uncoupling protein may participate in futile cycling of pyruvate and other monocarboxylates. |
9614211 | Mol. Pharmacol. | 1998 | De Kimpe SJ et al. | Reactive oxygen species regulate macrophage scavenger receptor type I, but not type II, in the human monocytic cell line THP-1. |
9707444 | EMBO J. | 1998 | Bai Y and Attardi G | The mtDNA-encoded ND6 subunit of mitochondrial NADH dehydrogenase is essential for the assembly of the membrane arm and the respiratory function of the enzyme. |
10200266 | Proc. Natl. Acad. Sci. U.S.A. | 1999 | Au HC et al. | The NDUFA1 gene product (MWFE protein) is essential for activity of complex I in mammalian mitochondria. |
10022826 | EMBO J. | 1999 | Liss B et al. | Alternative sulfonylurea receptor expression defines metabolic sensitivity of K-ATP channels in dopaminergic midbrain neurons. |
10463952 | FASEB J. | 1999 | Kiningham KK et al. | Overexpression of manganese superoxide dismutase protects against mitochondrial-initiated poly(ADP-ribose) polymerase-mediated cell death. |
11566731 | Biol. Reprod. | 2001 | Vernet P et al. | Analysis of reactive oxygen species generating systems in rat epididymal spermatozoa. |
11854175 | Hum. Mol. Genet. | 2002 | Wong A et al. | Differentiation-specific effects of LHON mutations introduced into neuronal NT2 cells. |
11356790 | J. Appl. Physiol. | 2001 | Reeve HL et al. | Alterations in a redox oxygen sensing mechanism in chronic hypoxia. |
11420302 | Circ. Res. | 2001 | Waypa GB et al. | Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing. |
11435296 | Blood | 2001 | Vaux EC et al. | Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain. |
12151355 | Carcinogenesis | 2002 | Tanaka T et al. | Modifying effects of dietary capsaicin and rotenone on 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis. |
12110535 | Am. J. Physiol. Endocrinol. Metab. | 2002 | MacDonald MJ | Differences between mouse and rat pancreatic islets: succinate responsiveness, malic enzyme, and anaplerosis. |
11950692 | Arterioscler. Thromb. Vasc. Biol. | 2002 | Pearlstein DP et al. | Role of mitochondrial oxidant generation in endothelial cell responses to hypoxia. |
11961005 | J. Am. Soc. Nephrol. | 2002 | Morigi M et al. | Protein overload-induced NF-kappaB activation in proximal tubular cells requires H(2)O(2) through a PKC-dependent pathway. |
11964372 | Circ. Res. | 2002 | Swärd K et al. | Influence of mitochondrial inhibition on global and local [Ca(2+)](I) in rat tail artery. |
12065751 | Mol. Pharmacol. | 2002 | Waldmeier PC et al. | Inhibition of the mitochondrial permeability transition by the nonimmunosuppressive cyclosporin derivative NIM811. |
12089069 | Circ. Res. | 2002 | Michelakis ED et al. | Diversity in mitochondrial function explains differences in vascular oxygen sensing. |
12812914 | Am. J. Physiol. Renal Physiol. | 2003 | Bouyer P et al. | An increase in intracellular calcium concentration that is induced by basolateral CO2 in rabbit renal proximal tubule. |
12952856 | Am. J. Physiol. Renal Physiol. | 2003 | Zager RA et al. | Proximal tubular cholesterol loading after mitochondrial, but not glycolytic, blockade. |
12958040 | Arterioscler. Thromb. Vasc. Biol. | 2003 | Cowan DB et al. | Hypoxia and stretch regulate intercellular communication in vascular smooth muscle cells through reactive oxygen species formation. |
12724545 | Plant Cell | 2003 | Dutilleul C et al. | Leaf mitochondria modulate whole cell redox homeostasis, set antioxidant capacity, and determine stress resistance through altered signaling and diurnal regulation. |
12601064 | Invest. Ophthalmol. Vis. Sci. | 2003 | Yang JH et al. | Blue light-induced generation of reactive oxygen species in photoreceptor ellipsoids requires mitochondrial electron transport. |
12591974 | J. Natl. Cancer Inst. | 2003 | Crowell JA and Steele VE | AKT and the phosphatidylinositol 3-kinase/AKT pathway: important molecular targets for lung cancer prevention and treatment. |
12591985 | J. Natl. Cancer Inst. | 2003 | Chun KH et al. | Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells. |
12376345 | Am. J. Physiol. Lung Cell Mol. Physiol. | 2002 | Schroedl C et al. | Hypoxic but not anoxic stabilization of HIF-1alpha requires mitochondrial reactive oxygen species. |
12517982 | J. Exp. Biol. | 2003 | Blackstone NW | Redox signaling in the growth and development of colonial hydroids. |
12919951 | Circ. Res. | 2003 | Liu Y et al. | Mitochondrial sources of H2O2 generation play a key role in flow-mediated dilation in human coronary resistance arteries. |
10600842 | Am. J. Physiol. | 1999 | Becker LB et al. | Generation of superoxide in cardiomyocytes during ischemia before reperfusion. |
10780954 | Am. J. Physiol. Endocrinol. Metab. | 2000 | Lin Z et al. | GLUT-1 reduces hypoxia-induced apoptosis and JNK pathway activation. |
11046005 | J. Immunol. | 2000 | Torres-Roca JF et al. | An early oxygen-dependent step is required for dexamethasone-induced apoptosis of immature mouse thymocytes. |
11076830 | Circulation | 2000 | Hu Q and Ziegelstein RC | Hypoxia/reoxygenation stimulates intracellular calcium oscillations in human aortic endothelial cells. |
11080300 | Plant Physiol. | 2000 | Sabar M et al. | Complex I impairment, respiratory compensations, and photosynthetic decrease in nuclear and mitochondrial male sterile mutants of Nicotiana sylvestris. |
10973919 | FASEB J. | 2000 | Deshpande SS et al. | Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: dual regulation by reactive oxygen species. |
10904037 | J. Appl. Physiol. | 2000 | Nethery D et al. | PLA(2) dependence of diaphragm mitochondrial formation of reactive oxygen species. |
10878378 | J. Immunol. | 2000 | Chandel NS et al. | Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin. |
9804614 | Mol. Pharmacol. | 1998 | Leist M et al. | 1-Methyl-4-phenylpyridinium induces autocrine excitotoxicity, protease activation, and neuronal apoptosis. |
14665431 | Am. J. Physiol. Renal Physiol. | 2004 | Feldkamp T et al. | Preservation of complex I function during hypoxia-reoxygenation-induced mitochondrial injury in proximal tubules. |
14638429 | FEMS Microbiol. Lett. | 2003 | Palese LL et al. | Characterization of plasma membrane respiratory chain and ATPase in the actinomycete Nonomuraea sp. ATCC 39727. |
14555771 | Plant Physiol. | 2003 | Millar AH et al. | Control of ascorbate synthesis by respiration and its implications for stress responses. |
15331767 | Mol. Pharmacol. | 2004 | Mason HS et al. | Selective modulation of ligand-gated P2X purinoceptor channels by acute hypoxia is mediated by reactive oxygen species. |
15342361 | Brain | 2004 | Beretta S et al. | Leber hereditary optic neuropathy mtDNA mutations disrupt glutamate transport in cybrid cell lines. |
15252205 | Proc. Natl. Acad. Sci. U.S.A. | 2004 | Yao D et al. | Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity. |
15268949 | FEMS Microbiol. Lett. | 2004 | Chen Y and Suzuki I | Effect of uncouplers on endogenous respiration and ferrous iron oxidation in a chemolithoautotrophic bacterium Acidithiobacillus (Thiobacillus) ferrooxidans. |
14962977 | Hum. Mol. Genet. | 2004 | Ruan Q et al. | Striatal cells from mutant huntingtin knock-in mice are selectively vulnerable to mitochondrial complex II inhibitor-induced cell death through a non-apoptotic pathway. |
14699012 | Circ. Res. | 2004 | Cherednichenko G et al. | NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release. |
14676274 | J. Cell. Sci. | 2004 | Baker MA et al. | Analysis of the mechanism by which calcium negatively regulates the tyrosine phosphorylation cascade associated with sperm capacitation. |
21300668 | Hypertension | 2011 | Rowlands DJ et al. | Equol-stimulated mitochondrial reactive oxygen species activate endothelial nitric oxide synthase and redox signaling in endothelial cells: roles for F-actin and GPR30. |
21159641 | Cancer Res. | 2010 | Maldonado EN et al. | Free tubulin modulates mitochondrial membrane potential in cancer cells. |
21212096 | J. Endocrinol. | 2011 | Caton PW et al. | Fructose induces gluconeogenesis and lipogenesis through a SIRT1-dependent mechanism. |
20940149 | Hum. Mol. Genet. | 2011 | Thomas KJ et al. | DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy. |
19276049 | Vet. Pathol. | 2009 | Allen AL et al. | Vascular pathology in male Lewis rats following short-term, low-dose rotenone administration. |
18832435 | Mol. Pharmacol. | 2009 | Hu LF et al. | Hydrogen sulfide inhibits rotenone-induced apoptosis via preservation of mitochondrial function. |
19297545 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | 2009 | Pilarski JQ et al. | Effects of aerobic and anaerobic metabolic inhibitors on avian intrapulmonary chemoreceptors. |
19692353 | Hum. Mol. Genet. | 2009 | Venderova K et al. | Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease. |
19776389 | Am. J. Physiol., Cell Physiol. | 2009 | Lustgarten MS et al. | Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity. |
18957561 | Clin. Chem. | 2008 | de Wit LE et al. | Correct assay of complex I activity in human skin fibroblasts by timely addition of rotenone. |
19131585 | J. Pharmacol. Exp. Ther. | 2009 | Han Z et al. | Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells. |
19542490 | Am. J. Physiol. Heart Circ. Physiol. | 2009 | Casals G et al. | Hypoxia induces B-type natriuretic peptide release in cell lines derived from human cardiomyocytes. |
19433547 | Infect. Immun. | 2009 | Martins RM et al. | Use of L-proline and ATP production by Trypanosoma cruzi metacyclic forms as requirements for host cell invasion. |
20185797 | Circ. Res. | 2010 | Ago T et al. | Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes. |
20100866 | Mol. Cell. Biol. | 2010 | Fogal V et al. | Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation. |
20089711 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | 2010 | Zoer B et al. | Hypoxia sensing in the fetal chicken femoral artery is mediated by the mitochondrial electron transport chain. |
17298981 | J. Cell. Sci. | 2007 | Benard G et al. | Mitochondrial bioenergetics and structural network organization. |
16837559 | J. Pharmacol. Exp. Ther. | 2006 | Wu J et al. | Iptakalim modulates ATP-sensitive K(+) channels in dopamine neurons from rat substantia nigra pars compacta. |
22072507 | J. Neurophysiol. | 2012 | Tu H et al. | Mitochondria-derived superoxide and voltage-gated sodium channels in baroreceptor neurons from chronic heart-failure rats. |
17967937 | J. Pharmacol. Exp. Ther. | 2008 | Kim JH et al. | Antiangiogenic effect of deguelin on choroidal neovascularization. |
17303708 | J. Appl. Physiol. | 2007 | Starnes JW et al. | Exercise training decreases rat heart mitochondria free radical generation but does not prevent Ca2+-induced dysfunction. |
17540903 | Science | 2007 | Reeves MB et al. | Complex I binding by a virally encoded RNA regulates mitochondria-induced cell death. |
17438209 | Biol. Bull. | 2007 | Tong JJ | Mitochondrial delivery is essential for synaptic potentiation. |
17428841 | Am. J. Physiol., Cell Physiol. | 2007 | Koopman WJ et al. | Human NADH:ubiquinone oxidoreductase deficiency: radical changes in mitochondrial morphology? |
17671207 | Cancer Res. | 2007 | Lluis JM et al. | Dual role of mitochondrial reactive oxygen species in hypoxia signaling: activation of nuclear factor-{kappa}B via c-SRC and oxidant-dependent cell death. |
18077608 | Am. J. Physiol., Cell Physiol. | 2008 | Chen Q et al. | Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria. |
18032788 | J. Cell. Sci. | 2007 | Chen Y et al. | Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species. |
18234847 | Am. J. Physiol., Cell Physiol. | 2008 | Buttigieg J et al. | Functional mitochondria are required for O2 but not CO2 sensing in immortalized adrenomedullary chromaffin cells. |
17878221 | Am. J. Physiol. Endocrinol. Metab. | 2007 | Glassford AJ et al. | HIF-1 regulates hypoxia- and insulin-induced expression of apelin in adipocytes. |
17726156 | J. Pharmacol. Exp. Ther. | 2007 | Watabe M and Nakaki T | Mitochondrial complex I inhibitor rotenone-elicited dopamine redistribution from vesicles to cytosol in human dopaminergic SH-SY5Y cells. |
18375872 | J. Gerontol. A Biol. Sci. Med. Sci. | 2008 | Salmon AB et al. | Fibroblasts from naked mole-rats are resistant to multiple forms of cell injury, but sensitive to peroxide, ultraviolet light, and endoplasmic reticulum stress. |
18397288 | FEMS Microbiol. Lett. | 2008 | Galvez Rojas RL et al. | L-Proline uptake in Crithidia deanei is influenced by its endosymbiont bacterium. |
18385062 | Invest. Ophthalmol. Vis. Sci. | 2008 | He Y et al. | Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants. |
15764673 | Am. J. Physiol. Heart Circ. Physiol. | 2005 | Bailey SR et al. | Reactive oxygen species from smooth muscle mitochondria initiate cold-induced constriction of cutaneous arteries. |
15647387 | Am. J. Physiol., Cell Physiol. | 2005 | Koopman WJ et al. | Inhibition of complex I of the electron transport chain causes O2-. -mediated mitochondrial outgrowth. |
15557194 | J. Immunol. | 2004 | Woo CH et al. | Lipopolysaccharide induces matrix metalloproteinase-9 expression via a mitochondrial reactive oxygen species-p38 kinase-activator protein-1 pathway in Raw 264.7 cells. |
15047621 | Diabetes | 2004 | Brunmair B et al. | Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions? |
14630960 | Plant Physiol. | 2003 | Moore CS et al. | Identification of AtNDI1, an internal non-phosphorylating NAD(P)H dehydrogenase in Arabidopsis mitochondria. |
16288123 | J. Natl. Cancer Inst. | 2005 | Lee HY et al. | Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis. |
16303854 | Am. J. Physiol. Renal Physiol. | 2006 | Zhou X et al. | Mitochondrial reactive oxygen species contribute to high NaCl-induced activation of the transcription factor TonEBP/OREBP. |
16278233 | Hum. Mol. Genet. | 2005 | Wang C et al. | Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function. |
15671057 | Mutagenesis | 2005 | Harvey JS et al. | The results of five coded compounds: genistein, metaproterenol, rotenone, p-anisidine and resorcinol tested in the pH 6.7 Syrian hamster embryo cell morphological transformation assay. |
15677497 | Diabetes | 2005 | Modesti A et al. | Hyperglycemia activates JAK2 signaling pathway in human failing myocytes via angiotensin II-mediated oxidative stress. |
15913578 | Cardiovasc. Res. | 2005 | Sato H et al. | Mitochondrial reactive oxygen species and c-Src play a critical role in hypoxic response in vascular smooth muscle cells. |
16972982 | FEMS Yeast Res. | 2006 | Liu L et al. | Significant increase of glycolytic flux in Torulopsis glabrata by inhibition of oxidative phosphorylation. |
16854843 | Mol. Cell Proteomics | 2007 | Jin J et al. | Identification of novel proteins associated with both alpha-synuclein and DJ-1. |
16565515 | Mol. Cell Proteomics | 2006 | Jin J et al. | Proteomic identification of a stress protein, mortalin/mthsp70/GRP75: relevance to Parkinson disease. |
16449798 | FASEB J. | 2006 | Hsieh CC and Papaconstantinou J | Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice. |
17015749 | J. Immunol. | 2006 | Nair AS et al. | Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion. |
16874299 | EMBO J. | 2006 | Barsoum MJ et al. | Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. |
16952909 | Carcinogenesis | 2007 | Dell'Eva R et al. | The Akt inhibitor deguelin, is an angiopreventive agent also acting on the NF-kappaB pathway. |
16987997 | Am. J. Physiol., Cell Physiol. | 2007 | Kuba M et al. | Bidirectional Ca2+ coupling of mitochondria with the endoplasmic reticulum and regulation of multimodal Ca2+ entries in rat brown adipocytes. |
16804079 | Diabetes | 2006 | Leloup C et al. | Mitochondrial reactive oxygen species are required for hypothalamic glucose sensing. |
16818739 | J. Immunol. | 2006 | Yi JS et al. | Electron transport complex I is required for CD8+ T cell function. |
16790527 | FASEB J. | 2006 | Aquilano K et al. | Mitochondrial damage due to SOD1 deficiency in SH-SY5Y neuroblastoma cells: a rationale for the redundancy of SOD1. |
16717263 | CMAJ | 2006 | Kurji K et al. | The lesser evils of battling round goby infiltration. |
16207793 | Am. J. Physiol., Cell Physiol. | 2006 | Potokar M et al. | Subcellular localization of Apaf-1 in apoptotic rat pituitary cells. |
16195374 | FASEB J. | 2005 | KC S et al. | Vitamin C enters mitochondria via facilitative glucose transporter 1 (Glut1) and confers mitochondrial protection against oxidative injury. |
18567827 | Plant Physiol. | 2008 | Ho LH et al. | Identification of regulatory pathways controlling gene expression of stress-responsive mitochondrial proteins in Arabidopsis. |
18599602 | Mol. Pharmacol. | 2008 | Watabe M and Nakaki T | Mitochondrial complex I inhibitor rotenone inhibits and redistributes vesicular monoamine transporter 2 via nitration in human dopaminergic SH-SY5Y cells. |
18614623 | Reproduction | 2008 | Callies C et al. | Channels for water efflux and influx involved in volume regulation of murine spermatozoa. |
18614807 | Invest. Ophthalmol. Vis. Sci. | 2008 | He Y et al. | Mitochondrial defects and dysfunction in calcium regulation in glaucomatous trabecular meshwork cells. |
18784283 | Plant Physiol. | 2008 | Garmier M et al. | Complex I dysfunction redirects cellular and mitochondrial metabolism in Arabidopsis. |
18812510 | Proc. Natl. Acad. Sci. U.S.A. | 2008 | Choi WS et al. | Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat. |
21975873 | Am. J. Physiol. Renal Physiol. | 2012 | Ohsaki Y et al. | Increase of sodium delivery stimulates the mitochondrial respiratory chain H2O2 production in rat renal medullary thick ascending limb. |
22330897 | J. Exp. Bot. | 2012 | Peckmann K et al. | Mitochondrial respiration in ME-CAM, PEPCK-CAM, and C₃ succulents: comparative operation of the cytochrome, alternative, and rotenone-resistant pathways. |
22229125 | Cold Spring Harb Perspect Med | 2011 | Tieu K | A guide to neurotoxic animal models of Parkinson's disease. |
22661471 | Invest. Ophthalmol. Vis. Sci. | 2012 | Daudt DR et al. | Methylene blue protects primary rat retinal ganglion cells from cellular senescence. |
22872702 | Hum. Mol. Genet. | 2012 | Joselin AP et al. | ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons. |
23788766 | Arterioscler. Thromb. Vasc. Biol. | 2013 | Pung YF et al. | Mitochondrial oxidative stress corrupts coronary collateral growth by activating adenosine monophosphate activated kinase-α signaling. |
23530063 | Mol. Cell. Biol. | 2013 | Hatle KM et al. | MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations. |
24150756 | Invest. Ophthalmol. Vis. Sci. | 2013 | Han G et al. | Mechanisms of neuroprotection by glucose in rat retinal cell cultures subjected to respiratory inhibition. |
24889636 | Proc. Natl. Acad. Sci. U.S.A. | 2014 | De Haes W et al. | Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2. |
9689052 | Proc. Natl. Acad. Sci. U.S.A. | 1998 | Seo BB et al. | Molecular remedy of complex I defects: rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cells. |
18235013 | Invest. Ophthalmol. Vis. Sci. | 2008 | Ghelli A et al. | Protection against oxidant-induced apoptosis by exogenous glutathione in Leber hereditary optic neuropathy cybrids. |
26358042 | FASEB J. | 2016 | Németh B et al. | Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage. |
25263579 | Exp. Neurol. | 2015 | Chiu CC et al. | Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism. |
26864693 | Am. J. Physiol., Cell Physiol. | 2016 | Jiang M et al. | Downregulation of miR-384-5p attenuates rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through inhibiting endoplasmic reticulum stress. |
26031332 | Mol. Cell. Biol. | 2015 | Hou YS et al. | Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation. |
25617244 | J. Pharmacol. Exp. Ther. | 2015 | Rios FJ et al. | Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through Nox-dependent processes. |
25496994 | Toxicology | 2015 | Choi WS et al. | JNK inhibition of VMAT2 contributes to rotenone-induced oxidative stress and dopamine neuron death. |
25461423 | Environ Int | 2015 | Furlong M et al. | Protective glove use and hygiene habits modify the associations of specific pesticides with Parkinson's disease. |
25136123 | Proc. Natl. Acad. Sci. U.S.A. | 2014 | Cleaver JE et al. | Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage. |
24792327 | Neurotoxicology | 2014 | Rojas-Charry L et al. | Downregulation of Pink1 influences mitochondrial fusion-fission machinery and sensitizes to neurotoxins in dopaminergic cells. |
24120951 | Parkinsonism Relat. Disord. | 2014 | Kamel F et al. | Dietary fat intake, pesticide use, and Parkinson's disease. |
23899557 | Cell. Signal. | 2013 | Green ML et al. | Release of targeted p53 from the mitochondrion as an early signal during mitochondrial dysfunction. |
17395008 | Free Radic. Biol. Med. | 2007 | Del Carlo M et al. | Endogenous production of reactive oxygen species is required for stimulation of human articular chondrocyte matrix metalloproteinase production by fibronectin fragments. |
27590850 | Int. J. Biochem. Cell Biol. | 2016 | Mot AI et al. | Circumventing the Crabtree Effect: A method to induce lactate consumption and increase oxidative phosphorylation in cell culture. |
27413198 | Am. J. Physiol. Renal Physiol. | 2016 | Sun Y et al. | Inhibition of mitochondrial complex-1 restores the downregulation of aquaporins in obstructive nephropathy. |
27157538 | Biochim. Biophys. Acta | 2016 | Shindo Y et al. | Altered expression of Mg(2+) transport proteins during Parkinson's disease-like dopaminergic cell degeneration in PC12 cells. |
26873970 | Am. J. Physiol. Heart Circ. Physiol. | 2016 | Ochi R et al. | Rotenone-stimulated superoxide release from mitochondrial complex I acutely augments L-type Ca2+ current in A7r5 aortic smooth muscle cells. |
26142652 | J Pain | 2015 | Griffiths LA and Flatters SJ | Pharmacological Modulation of the Mitochondrial Electron Transport Chain in Paclitaxel-Induced Painful Peripheral Neuropathy. |
26141374 | Brain Res. | 2015 | Hawong HY et al. | Comparison of the structure, function and autophagic maintenance of mitochondria in nigrostriatal and tuberoinfundibular dopamine neurons. |
25862939 | Neurobiol. Dis. | 2015 | Slone SR et al. | Increased 14-3-3 phosphorylation observed in Parkinson's disease reduces neuroprotective potential of 14-3-3 proteins. |
25827955 | Biochim. Biophys. Acta | 2015 | Grefte S et al. | Rotenone inhibits primary murine myotube formation via Raf-1 and ROCK2. |
25481764 | Neurosci. Lett. | 2015 | Zhang L et al. | Long-term evaluation of Leber's hereditary optic neuropathy-like symptoms in rotenone administered rats. |
25155595 | Antimicrob. Agents Chemother. | 2014 | Mesa-Arango AC et al. | The production of reactive oxygen species is a universal action mechanism of Amphotericin B against pathogenic yeasts and contributes to the fungicidal effect of this drug. |
25063855 | J. Exp. Biol. | 2014 | Dukoff DJ et al. | Scavenging ROS dramatically increase NMDA receptor whole-cell currents in painted turtle cortical neurons. |
25034910 | Exp. Gerontol. | 2014 | LaRocca TJ et al. | Mitochondrial quality control and age-associated arterial stiffening. |
24981012 | Neurobiol. Dis. | 2014 | Sanders LH et al. | Mitochondrial DNA damage: molecular marker of vulnerable nigral neurons in Parkinson's disease. |
24965893 | Neurobiol. Dis. | 2014 | Hwang RD et al. | The neuroprotective effect of human uncoupling protein 2 (hUCP2) requires cAMP-dependent protein kinase in a toxin model of Parkinson's disease. |
24191234 | Redox Biol | 2013 | Mistry Y et al. | A role for mitochondrial oxidants in stress-induced premature senescence of human vascular smooth muscle cells. |
24045019 | Plant Cell | 2013 | De Clercq I et al. | The membrane-bound NAC transcription factor ANAC013 functions in mitochondrial retrograde regulation of the oxidative stress response in Arabidopsis. |