quercetin

quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.

References related to functions published in Others


PMIDJournalPublished DateAuthorTitle
9409251Arterioscler. Thromb. Vasc. Biol.1997Hayek T et al.Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation.
9746465Am. J. Physiol.1998Flesch M et al.Effects of red and white wine on endothelium-dependent vasorelaxation of rat aorta and human coronary arteries.
9815047Am. J. Physiol.1998Cermak R et al.Dietary flavonol quercetin induces chloride secretion in rat colon.
10409158Am. J. Physiol.1999Crespy V et al.Part of quercetin absorbed in the small intestine is conjugated and further secreted in the intestinal lumen.
9590266J. Immunol.1998Senyshyn J et al.Quercetin sensitizes RBL-2H3 cells to polybasic mast cell secretagogues through increased expression of Gi GTP-binding proteins linked to a phospholipase C signaling pathway.
10541287J. Am. Soc. Nephrol.1999Ishikawa Y et al.Bioflavonoid quercetin inhibits interleukin-1-induced transcriptional expression of monocyte chemoattractant protein-1 in glomerular cells via suppression of nuclear factor-kappaB.
10484327Am. J. Physiol.1999Kobuchi H et al.Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway.
11245615Am. J. Physiol., Cell Physiol.2001Cao W et al.Ca2+-induced contraction of cat esophageal circular smooth muscle cells.
11722907Appl. Environ. Microbiol.2001Braune A et al.Degradation of quercetin and luteolin by Eubacterium ramulus.
11562426Mol. Pharmacol.2001Yoshizumi M et al.Quercetin inhibits Shc- and phosphatidylinositol 3-kinase-mediated c-Jun N-terminal kinase activation by angiotensin II in cultured rat aortic smooth muscle cells.
11502522Antimicrob. Agents Chemother.2001Vandegraaff N et al.Specific inhibition of human immunodeficiency virus type 1 (HIV-1) integration in cell culture: putative inhibitors of HIV-1 integrase.
11502892Mol. Pharmacol.2001Maggiolini M et al.Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells.
11752233Mutagenesis2002Lautraite S et al.Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1.
11772620Appl. Environ. Microbiol.2002Pillai BV and Swarup SElucidation of the flavonoid catabolism pathway in Pseudomonas putida PML2 by comparative metabolic profiling.
11320154Mutagenesis2001Zhao C et al.Fast repair of the radical cations of dCMP and poly C by quercetin and rutin.
11306697Mol. Pharmacol.2001Sidhu JS et al.PI3K inhibitors reverse the suppressive actions of insulin on CYP2E1 expression by activating stress-response pathways in primary rat hepatocytes.
11356561FEMS Microbiol. Lett.2001Neu JM and Wright GDInhibition of sporulation, glycopeptide antibiotic production and resistance in Streptomyces toyocaensis NRRL 15009 by protein kinase inhibitors.
11333849Am. J. Clin. Nutr.2001Koga T and Meydani MEffect of plasma metabolites of (+)-catechin and quercetin on monocyte adhesion to human aortic endothelial cells.
11408547J. Pharmacol. Exp. Ther.2001Vernhet L et al.Arsenic induces expression of the multidrug resistance-associated protein 2 (MRP2) gene in primary rat and human hepatocytes.
11432953J. Exp. Bot.2001Kidd PS et al.The role of root exudates in aluminium resistance and silicon-induced amelioration of aluminium toxicity in three varieties of maize (Zea mays L.).
12147723J. Exp. Bot.2002Novák K et al.Effect of exogenous flavonoids on nodulation of pea (Pisum sativum L.).
12134086Mol. Biol. Cell2002Volonte D et al.Expression of caveolin-1 induces premature cellular senescence in primary cultures of murine fibroblasts.
11934488FEMS Microbiol. Lett.2002Denny BJ et al.The flavonoid galangin inhibits the L1 metallo-beta-lactamase from Stenotrophomonas maltophilia.
12097402J. Immunol.2002Dobbin CA et al.Heat shock protein 70 is a potential virulence factor in murine toxoplasma infection via immunomodulation of host NF-kappa B and nitric oxide.
12065701J. Pharmacol. Exp. Ther.2002Pérez-Vizcaíno F et al.Endothelium-independent vasodilator effects of the flavonoid quercetin and its methylated metabolites in rat conductance and resistance arteries.
12391264Mol. Pharmacol.2002Maggiolini M et al.The mutant androgen receptor T877A mediates the proliferative but not the cytotoxic dose-dependent effects of genistein and quercetin on human LNCaP prostate cancer cells.
12815032J. Exp. Bot.2003Solovchenko A and Schmitz-Eiberger MSignificance of skin flavonoids for UV-B-protection in apple fruits.
12695340Drug Metab. Dispos.2003Raucy JLRegulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products.
12724357J. Cell. Sci.2003Luparello C et al.PTHrP [67-86] regulates the expression of stress proteins in breast cancer cells inducing modifications in urokinase-plasminogen activator and MMP-1 expression.
12756216Drug Metab. Dispos.2003Petri N et al.Absorption/metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo.
12376640Plant Physiol.2002Jaakola L et al.Expression of genes involved in anthocyanin biosynthesis in relation to anthocyanin, proanthocyanidin, and flavonol levels during bilberry fruit development.
12936951Am. J. Clin. Nutr.2003Prior RLFruits and vegetables in the prevention of cellular oxidative damage.
12837746J. Antimicrob. Chemother.2003Chiang LC et al.In vitro antiviral activities of Caesalpinia pulcherrima and its related flavonoids.
10564243Am. J. Physiol.1999Rangan GK et al.Inhibition of NFkappaB activation with antioxidants is correlated with reduced cytokine transcription in PTC.
10604938J. Pharmacol. Exp. Ther.2000Chahdi A et al.Compound 48/80 activates mast cell phospholipase D via heterotrimeric GTP-binding proteins.
11053056Am. J. Physiol. Renal Physiol.2000Ishikawa Y et al.Spontaneous shift in transcriptional profile of explanted glomeruli via activation of the MAP kinase family.
11108730J. Lipid Res.2000Theriault A et al.Modulation of hepatic lipoprotein synthesis and secretion by taxifolin, a plant flavonoid.
11123379J. Pharmacol. Exp. Ther.2001Xagorari A et al.Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages.
11063442Am. J. Clin. Nutr.2000Pignatelli P et al.The flavonoids quercetin and catechin synergistically inhibit platelet function by antagonizing the intracellular production of hydrogen peroxide.
10945830J. Pharmacol. Exp. Ther.2000Walgren RA et al.Efflux of dietary flavonoid quercetin 4'-beta-glucoside across human intestinal Caco-2 cell monolayers by apical multidrug resistance-associated protein-2.
10938233Am. J. Physiol. Regul. Integr. Comp. Physiol.2000Moon JH et al.Accumulation of quercetin conjugates in blood plasma after the short-term ingestion of onion by women.
10995824J. Neurosci.2000Wender R et al.Astrocytic glycogen influences axon function and survival during glucose deprivation in central white matter.
10926634J. Appl. Physiol.2000Posterino GS and Fryer MWEffects of high myoplasmic L-lactate concentration on E-C coupling in mammalian skeletal muscle.
10871299J. Pharmacol. Exp. Ther.2000Obach RSInhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression.
10850441Cancer Res.2000Yokota S et al.Benzylidene lactam compound, KNK437, a novel inhibitor of acquisition of thermotolerance and heat shock protein induction in human colon carcinoma cells.
9758774Appl. Environ. Microbiol.1998Riou C et al.Purification, characterization, and substrate specificity of a novel highly glucose-tolerant beta-glucosidase from Aspergillus oryzae.
9925128Am. J. Clin. Nutr.1999Young JF et al.Effect of fruit juice intake on urinary quercetin excretion and biomarkers of antioxidative status.
15169886Mol. Cell. Biol.2004Gouédard C et al.Dietary polyphenols increase paraoxonase 1 gene expression by an aryl hydrocarbon receptor-dependent mechanism.
14633740Cancer Res.2003Schwarz D et al.St. John's wort extracts and some of their constituents potently inhibit ultimate carcinogen formation from benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1.
14532034Appl. Environ. Microbiol.2003Schoefer L et al.Anaerobic degradation of flavonoids by Clostridium orbiscindens.
15292045Am. J. Physiol. Renal Physiol.2004Niisato N et al.Involvement of cytosolic Cl- in osmoregulation of alpha-ENaC gene expression.
15308478Am. J. Physiol. Heart Circ. Physiol.2004Benito S et al.Flavonoid metabolites and susceptibility of rat lipoproteins to oxidation.
15180920Am. J. Physiol. Lung Cell Mol. Physiol.2004Donnelly LE et al.Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms.
15155557Drug Metab. Dispos.2004Walsky RL and Obach RSValidated assays for human cytochrome P450 activities.
14715546Clin. Diagn. Lab. Immunol.2004Nair HK et al.Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes.
20688844Ann. Oncol.2011Ekström AM et al.Dietary quercetin intake and risk of gastric cancer: results from a population-based study in Sweden.
20719748Toxicol. Sci.2010Raafat K et al.Synergistic inhibition of glycinergic transmission in vitro and in vivo by flavonoids and strychnine.
21138867Clin. Cancer Res.2010Cheng S et al.Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.
21051700Invest. Ophthalmol. Vis. Sci.2011Miyamoto N et al.Quercetin induces the expression of peroxiredoxins 3 and 5 via the Nrf2/NRF1 transcription pathway.
21632981Mutagenesis2011Magkoufopoulou C et al.Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells.
21543555Drug Metab. Dispos.2011Bolling BW et al.Microsomal quercetin glucuronidation in rat small intestine depends on age and segment.
21177254Toxicol. Sci.2011Vanhees K et al.Prenatal exposure to flavonoids: implication for cancer risk.
21209365Am. J. Physiol., Cell Physiol.2011Ramirez-Sanchez I et al.(-)-Epicatechin induces calcium and translocation independent eNOS activation in arterial endothelial cells.
21602180Nephrol. Dial. Transplant.2011Sanchez-Gonzalez PD et al.Quercetin reduces cisplatin nephrotoxicity in rats without compromising its anti-tumour activity.
21613575Am. J. Physiol. Regul. Integr. Comp. Physiol.2011Kuennen M et al.Thermotolerance and heat acclimation may share a common mechanism in humans.
20943792Am. J. Clin. Nutr.2010Chuang CC et al.Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-{alpha}-mediated inflammation and insulin resistance in primary human adipocytes.
19211721Am. J. Physiol. Regul. Integr. Comp. Physiol.2009Davis JM et al.Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance.
19265134J. Immunol.2009Capini C et al.Antigen-specific suppression of inflammatory arthritis using liposomes.
18852136Mol. Cancer Ther.2008Priego S et al.Natural polyphenols facilitate elimination of HT-29 colorectal cancer xenografts by chemoradiotherapy: a Bcl-2- and superoxide dismutase 2-dependent mechanism.
18971417Neuro-oncology2009Siegelin MD et al.Quercetin promotes degradation of survivin and thereby enhances death-receptor-mediated apoptosis in glioma cells.
19325051Am. J. Physiol. Gastrointest. Liver Physiol.2009Yao P et al.The protective role of HO-1 and its generated products (CO, bilirubin, and Fe) in ethanol-induced human hepatocyte damage.
19299563Mol. Pharmacol.2009Flaveny CA et al.Ligand selectivity and gene regulation by the human aryl hydrocarbon receptor in transgenic mice.
19706629Cardiovasc. Res.2010Maestro A et al.Expression of bilitranslocase in the vascular endothelium and its function as a flavonoid transporter.
19020291Am. J. Physiol. Regul. Integr. Comp. Physiol.2009Cheuvront SN et al.No effect of nutritional adenosine receptor antagonists on exercise performance in the heat.
19138980Cancer Prev Res (Phila)2008Olson ER et al.Stabilization of quercetin paradoxically reduces its proapoptotic effect on UVB-irradiated human keratinocytes.
19474275Nephrol. Dial. Transplant.2009Hu Q et al.In vitro anti-fibrotic activities of herbal compounds and herbs.
19605544Am. J. Physiol. Renal Physiol.2009Hu QH et al.Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvement.
19403594Br J Anaesth2009Goebel U et al.Protective effects of inhaled carbon monoxide in pig lungs during cardiopulmonary bypass are mediated via an induction of the heat shock response.
19414395Anticancer Res.2009Li X and Choi JSEffects of quercetin on the pharmacokinetics of Etoposide after oral or intravenous administration of etoposide in rats.
19331131Anticancer Res.2009Reiter M et al.Antioxidant effects of quercetin and coenzyme Q10 in mini organ cultures of human nasal mucosa cells.
20483746J. Immunol.2010Huang RY et al.Immunosuppressive effect of quercetin on dendritic cell activation and function.
20628003Cancer Prev Res (Phila)2010Howells LM et al.Preclinical colorectal cancer chemopreventive efficacy and p53-modulating activity of 3',4',5'-trimethoxyflavonol, a quercetin analogue.
20156843Mutagenesis2010Attia SMThe impact of quercetin on cisplatin-induced clastogenesis and apoptosis in murine marrow cells.
20032413Anticancer Res.2009Kawahara T et al.Cyclopamine and quercetin suppress the growth of leukemia and lymphoma cells.
22084064Proc. Natl. Acad. Sci. U.S.A.2011Kumar MR et al.Nitrosyl hydride (HNO) replaces dioxygen in nitroxygenase activity of manganese quercetin dioxygenase.
21775390Eur. Heart J.2012Bouitbir J et al.Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a 'mitohormesis' mechanism involving reactive oxygen species and PGC-1.
21885874Toxicol Pathol2011de David C et al.Role of quercetin in preventing thioacetamide-induced liver injury in rats.
21933852Haematologica2012Jacquemin G et al.Quercetin-mediated Mcl-1 and survivin downregulation restores TRAIL-induced apoptosis in non-Hodgkin's lymphoma B cells.
17332522J. Endocrinol.2007Chen YC et al.Effects of genistein, resveratrol, and quercetin on steroidogenesis and proliferation of MA-10 mouse Leydig tumor cells.
17293380Drug Metab. Dispos.2007Ung D and Nagar SVariable sulfation of dietary polyphenols by recombinant human sulfotransferase (SULT) 1A1 genetic variants and SULT1E1.
17377063Mol. Pharmacol.2007Jeon H et al.Quercetin activates an angiogenic pathway, hypoxia inducible factor (HIF)-1-vascular endothelial growth factor, by inhibiting HIF-prolyl hydroxylase: a structural analysis of quercetin for inhibiting HIF-prolyl hydroxylase.
17513788J. Immunol.2007Tang D et al.Nuclear heat shock protein 72 as a negative regulator of oxidative stress (hydrogen peroxide)-induced HMGB1 cytoplasmic translocation and release.
17483215J. Bacteriol.2007Hirooka K et al.Dual regulation of the Bacillus subtilis regulon comprising the lmrAB and yxaGH operons and yxaF gene by two transcriptional repressors, LmrA and YxaF, in response to flavonoids.
17478601Drug Metab. Dispos.2007Williamson G et al.Interaction of positional isomers of quercetin glucuronides with the transporter ABCC2 (cMOAT, MRP2).
17634198Am. J. Physiol. Regul. Integr. Comp. Physiol.2007Reilly N et al.Probiotics potentiate IL-6 production in IL-1beta-treated Caco-2 cells through a heat shock-dependent mechanism.
17652743Invest. Ophthalmol. Vis. Sci.2007Cao XG et al.Responses of human lens epithelial cells to quercetin and DMSO.
18245498Cancer Res.2008Lee KW et al.Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine.
17876056Mol. Cancer Ther.2007Psahoulia FH et al.Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts.
17693424Toxicol. Sci.2007Gregus Z and Németi BGlutathione-dependent reduction of arsenate by glycogen phosphorylase responsiveness to endogenous and xenobiotic inhibitors.
18385095Invest. Ophthalmol. Vis. Sci.2008Kook D et al.The protective effect of quercetin against oxidative stress in the human RPE in vitro.
15829497Hum. Mol. Genet.2005Waite KA et al.Phytoestrogen exposure elevates PTEN levels.
15833931Drug Metab. Dispos.2005Graf BA et al.Disposition and metabolism of [2-14C]quercetin-4'-glucoside in rats.
15749994Mol. Pharmacol.2005Sesink AL et al.Breast cancer resistance protein (Bcrp1/Abcg2) limits net intestinal uptake of quercetin in rats by facilitating apical efflux of glucuronides.
15608134Drug Metab. Dispos.2005Annaert PP and Brouwer KLAssessment of drug interactions in hepatobiliary transport using rhodamine 123 in sandwich-cultured rat hepatocytes.
15640492Am. J. Clin. Nutr.2005Lambert JD et al.Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.
14982785Antimicrob. Agents Chemother.2004Mamani-Matsuda M et al.Quercetin induces apoptosis of Trypanosoma brucei gambiense and decreases the proinflammatory response of human macrophages.
15044614Mol. Pharmacol.2004López-López G et al.Nitric oxide (NO) scavenging and NO protecting effects of quercetin and their biological significance in vascular smooth muscle.
16280456Drug Metab. Dispos.2006Yang JH et al.Inhibition of lung cancer cell growth by quercetin glucuronides via G2/M arrest and induction of apoptosis.
15483196Drug Metab. Dispos.2004Schrag ML et al.Sulfotransferase 1E1 is a low km isoform mediating the 3-O-sulfation of ethinyl estradiol.
15914627Invest. Ophthalmol. Vis. Sci.2005Awasthi N and Wagner BJUpregulation of heat shock protein expression by proteasome inhibition: an antiapoptotic mechanism in the lens.
16505238Diabetes2006Ye DZ et al.MafA expression and insulin promoter activity are induced by nicotinamide and related compounds in INS-1 pancreatic beta-cells.
16455785Am. J. Physiol. Gastrointest. Liver Physiol.2006Mutch DM et al.Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.
17077187Toxicol. Sci.2007Ebert B et al.Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate.
16950806Mutagenesis2006Cantero G et al.Topoisomerase II inhibition and high yield of endoreduplication induced by the flavonoids luteolin and quercetin.
17138861J. Pharmacol. Exp. Ther.2007Mandal AK et al.Hepatoprotective activity of liposomal flavonoid against arsenite-induced liver fibrosis.
17148581Blood2007Román-Gómez J et al.Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia.
17055466Cardiovasc. Res.2007Cogolludo A et al.The dietary flavonoid quercetin activates BKCa currents in coronary arteries via production of H2O2. Role in vasodilatation.
16522772Clin. Vaccine Immunol.2006Nair MP et al.The flavonoid quercetin inhibits proinflammatory cytokine (tumor necrosis factor alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-kappa beta system.
16825703Am. J. Clin. Nutr.2006Castilla P et al.Concentrated red grape juice exerts antioxidant, hypolipidemic, and antiinflammatory effects in both hemodialysis patients and healthy subjects.
16770007FASEB J.2006Pignatelli P et al.Polyphenols enhance platelet nitric oxide by inhibiting protein kinase C-dependent NADPH oxidase activation: effect on platelet recruitment.
16707620Clin. Cancer Res.2006Yuan ZP et al.Liposomal quercetin efficiently suppresses growth of solid tumors in murine models.
16177238Toxicol. Sci.2005Zhang YMProtective effect of quercetin on aroclor 1254-induced oxidative damage in cultured chicken spermatogonial cells.
16178122Toxicol Pathol2005Kitamura Y et al.Effects of N-acetylcysteine, quercetin, and phytic acid on spontaneous hepatic and renal lesions in LEC rats.
17234771Cancer Res.2007Aghdassi A et al.Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.
18579649Am. J. Physiol. Regul. Integr. Comp. Physiol.2008Davis JM et al.Quercetin reduces susceptibility to influenza infection following stressful exercise.
18633129Blood2008Liu FT et al.Dietary flavonoids inhibit the anticancer effects of the proteasome inhibitor bortezomib.
18625009FEMS Immunol. Med. Microbiol.2008Sugiyama T et al.Quercetin but not luteolin suppresses the induction of lethal shock upon infection of mice with Salmonella typhimurium.
18787224Blood2008Gelebart P et al.Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma.
22584252Drug Metab. Dispos.2012Kim HG et al.The increased cellular uptake and biliary excretion of curcumin by quercetin: a possible role of albumin binding interaction.
22549467EMBO J.2012Henrichs S et al.Regulation of ABCB1/PGP1-catalysed auxin transport by linker phosphorylation.
22332099Adv Nutr2012Larson AJ et al.Therapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanisms.
22334599Mutagenesis2012Vanhees K et al.Maternal intake of quercetin during gestation alters ex vivo benzo[a]pyrene metabolism and DNA adduct formation in adult offspring.
22933322Cardiovasc. Res.2012Lu TS et al.Induction of intracellular heat-shock protein 72 prevents the development of vascular smooth muscle cell calcification.
22213289Anticancer Res.2012Samuel T et al.Dual-mode interaction between quercetin and DNA-damaging drugs in cancer cells.
22492444Appl. Environ. Microbiol.2012Yoon JA et al.Production of a novel quercetin glycoside through metabolic engineering of Escherichia coli.
22869926J. Pharmacol. Exp. Ther.2012Lara-Guzman OJ et al.Proatherogenic macrophage activities are targeted by the flavonoid quercetin.
22871832Invest. Ophthalmol. Vis. Sci.2012Yoon JS et al.Antifibrotic effects of quercetin in primary orbital fibroblasts and orbital fat tissue cultures of Graves' orbitopathy.
23873842Am. J. Physiol. Lung Cell Mol. Physiol.2013Townsend EA and Emala CWQuercetin acutely relaxes airway smooth muscle and potentiates β-agonist-induced relaxation via dual phosphodiesterase inhibition of PLCβ and PDE4.
23396585Cancer Res.2013Cao J et al.Targeted cancer therapy with a 2-deoxyglucose-based adriamycin complex.
23197198Toxicol Pathol2013Vásquez-Garzón VR et al.The chemopreventive capacity of quercetin to induce programmed cell death in hepatocarcinogenesis.
23117658Arterioscler. Thromb. Vasc. Biol.2013Beazley KE et al.Transglutaminase inhibitors attenuate vascular calcification in a preclinical model.
23097297FASEB J.2013Ho L et al.Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.
23035181Cancer Epidemiol. Biomarkers Prev.2012Lam TK et al.Influence of quercetin-rich food intake on microRNA expression in lung cancer tissues.
23564507Am. J. Physiol. Lung Cell Mol. Physiol.2013Lee KH and Yoo CGSimultaneous inactivation of GSK-3β suppresses quercetin-induced apoptosis by inhibiting the JNK pathway.
23143154J. Endocrinol.2013Yoon JS et al.Cigarette smoke extract-induced adipogenesis in Graves' orbital fibroblasts is inhibited by quercetin via reduction in oxidative stress.
24174370Endocr. Relat. Cancer2014Morais-Santos F et al.Differential sensitivities to lactate transport inhibitors of breast cancer cell lines.
24065861Drug Metab. Dispos.2013Zhuang XM et al.Assessment of the roles of P-glycoprotein and cytochrome P450 in triptolide-induced liver toxicity in sandwich-cultured rat hepatocyte model.
10961967Circulation2000Blanco-Colio LM et al.Red wine intake prevents nuclear factor-kappaB activation in peripheral blood mononuclear cells of healthy volunteers during postprandial lipemia.
23313938Mol. Pharmacol.2013Santos Mde S et al.Inhibitors of PI(4,5)P2 synthesis reveal dynamic regulation of IgE receptor signaling by phosphoinositides in RBL mast cells.