apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

References related to functions published in Others

PMID	Journal	Published Date	Author	Title
11673497	J. Immunol.	2001	Shen J et al.	Phosphorylation by the protein kinase CK2 promotes calpain-mediated degradation of IkappaBalpha.
11842175	Plant Physiol.	2002	Frangne N et al.	Flavone glucoside uptake into barley mesophyll and Arabidopsis cell culture vacuoles. Energization occurs by H(+)-antiport and ATP-binding cassette-type mechanisms.
12651632	Am. J. Physiol. Lung Cell Mol. Physiol.	2003	Caci E et al.	CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds.
12604700	J. Pharmacol. Exp. Ther.	2003	Chen J et al.	Metabolism of flavonoids via enteric recycling: role of intestinal disposition.
12485947	Drug Metab. Dispos.	2003	Leslie EM et al.	Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1).
12893842	J. Pharmacol. Exp. Ther.	2003	Hu M et al.	Metabolism of flavonoids via enteric recycling: mechanistic studies of disposition of apigenin in the Caco-2 cell culture model.
12842827	Am. J. Physiol. Gastrointest. Liver Physiol.	2003	Farah M et al.	5,6-Dichloro-ribifuranosylbenzimidazole- and apigenin-induced sensitization of colon cancer cells to TNF-alpha-mediated apoptosis.
11078699	Am. J. Physiol., Cell Physiol.	2000	Illek B et al.	Structural determinants for activation and block of CFTR-mediated chloride currents by apigenin.
14563892	J. Antimicrob. Chemother.	2003	Koo H et al.	Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesol.
15131058	Clin. Cancer Res.	2004	Shukla S and Gupta S	Suppression of constitutive and tumor necrosis factor alpha-induced nuclear factor (NF)-kappaB activation and induction of apoptosis by apigenin in human prostate carcinoma PC-3 cells: correlation with down-regulation of NF-kappaB-responsive genes.
14709621	Drug Metab. Dispos.	2004	Gradolatto A et al.	Metabolism of apigenin by rat liver phase I and phase ii enzymes and by isolated perfused rat liver.
14608117	J. Nutr.	2003	Van Dross R et al.	The chemopreventive bioflavonoid apigenin modulates signal transduction pathways in keratinocyte and colon carcinoma cell lines.
21106916	Am. J. Clin. Nutr.	2011	Cassidy A et al.	Habitual intake of flavonoid subclasses and incident hypertension in adults.
21505181	Cancer Prev Res (Phila)	2011	Mafuvadze B et al.	Apigenin prevents development of medroxyprogesterone acetate-accelerated 7,12-dimethylbenz(a)anthracene-induced mammary tumors in Sprague-Dawley rats.
19255256	FASEB J.	2009	Chiang HC et al.	Distinctive roles of different beta-amyloid 42 aggregates in modulation of synaptic functions.
18952844	Proc. Natl. Acad. Sci. U.S.A.	2008	Cai X and Liu X	Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage.
19398503	Drug Metab. Dispos.	2009	Maeno K et al.	Molecular basis for reduced estrone sulfate transport and altered modulator sensitivity of transmembrane helix (TM) 6 and TM17 mutants of multidrug resistance protein 1 (ABCC1).
19403720	J. Nutr.	2009	Hanske L et al.	The bioavailability of apigenin-7-glucoside is influenced by human intestinal microbiota in rats.
19377065	J. Antimicrob. Chemother.	2009	Wong IL et al.	Quinacrine and a novel apigenin dimer can synergistically increase the pentamidine susceptibility of the protozoan parasite Leishmania.
20511675	Exp. Biol. Med. (Maywood)	2010	Leonardi T et al.	Apigenin and naringenin suppress colon carcinogenesis through the aberrant crypt stage in azoxymethane-treated rats.
21346142	Mol. Pharmacol.	2011	Zhou Y et al.	Mucin 1 C-terminal subunit oncoprotein is a target for small-molecule inhibitors.
17982104	J. Immunol.	2007	Nicholas C et al.	Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.
17289898	Clin. Cancer Res.	2007	Kim JS et al.	Protein kinase CK2alpha as an unfavorable prognostic marker and novel therapeutic target in acute myeloid leukemia.
17369433	Plant Physiol.	2007	Marinova K et al.	Flavonoid biosynthesis in barley primary leaves requires the presence of the vacuole and controls the activity of vacuolar flavonoid transport.
17638904	Cancer Res.	2007	Shukla S et al.	Blockade of beta-catenin signaling by plant flavonoid apigenin suppresses prostate carcinogenesis in TRAMP mice.
18178667	Mol. Pharmacol.	2008	Puppala D et al.	Development of an aryl hydrocarbon receptor antagonist using the proteolysis-targeting chimeric molecules approach: a potential tool for chemoprevention.
18413777	Cancer Res.	2008	Abu-Yousif AO et al.	Enhancement of UVB-induced apoptosis by apigenin in human keratinocytes and organotypic keratinocyte cultures.
15746177	FASEB J.	2005	Fang J et al.	Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways.
16246933	J. Dent. Res.	2005	Koo H et al.	Apigenin and tt-farnesol with fluoride effects on S. mutans biofilms and dental caries.
16230333	FASEB J.	2005	Shukla S et al.	Up-regulation of insulin-like growth factor binding protein-3 by apigenin leads to growth inhibition and apoptosis of 22Rv1 xenograft in athymic nude mice.
15466493	Drug Metab. Dispos.	2005	Gradolatto A et al.	Pharmacokinetics and metabolism of apigenin in female and male rats after a single oral administration.
15897466	Proc. Natl. Acad. Sci. U.S.A.	2005	Yamada M et al.	Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis.
15947208	Mol. Pharmacol.	2005	Liu LZ et al.	Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancer.
16436708	Antimicrob. Agents Chemother.	2006	Koo H et al.	Influence of apigenin on gtf gene expression in Streptococcus mutans UA159.
17074806	Mol. Cell. Biol.	2007	Tong X et al.	Apigenin prevents UVB-induced cyclooxygenase 2 expression: coupled mRNA stabilization and translational inhibition.
16782805	Mol. Pharmacol.	2006	Yoon MS et al.	Apigenin inhibits immunostimulatory function of dendritic cells: Implication of immunotherapeutic adjuvant.
16581776	Mol. Cell. Biol.	2006	Li X et al.	NKX3.1 is regulated by protein kinase CK2 in prostate tumor cells.
17194831	Antimicrob. Agents Chemother.	2007	Wong IL et al.	Flavonoid dimers as bivalent modulators for pentamidine and sodium stiboglucanate resistance in leishmania.
22961906	Appl. Environ. Microbiol.	2012	Braune A and Blaut M	Intestinal bacterium Eubacterium cellulosolvens deglycosylates flavonoid C- and O-glucosides.
22923679	Plant Physiol.	2012	Berim A et al.	A set of regioselective O-methyltransferases gives rise to the complex pattern of methoxylated flavones in sweet basil.
23475986	Mol. Hum. Reprod.	2013	Lim R et al.	Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.
23697369	Proc. Natl. Acad. Sci. U.S.A.	2013	Arango D et al.	Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets.
23113475	FEMS Microbiol. Lett.	2013	Dong J et al.	Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.
20534735	Plant Physiol.	2010	Brechenmacher L et al.	Soybean metabolites regulated in root hairs in response to the symbiotic bacterium Bradyrhizobium japonicum.
21467581	Plant Cell	2011	Zhao J et al.	MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.
28396216	Toxicol. Appl. Pharmacol.	2017	Lecomte S et al.	Assessment of the potential activity of major dietary compounds as selective estrogen receptor modulators in two distinct cell models for proliferation and differentiation.
20693356	Plant Cell	2010	Ono E et al.	Functional differentiation of the glycosyltransferases that contribute to the chemical diversity of bioactive flavonol glycosides in grapevines (Vitis vinifera).
20346967	Int. J. Biol. Macromol.	2010	Chinnam N et al.	Dietary bioflavonoids inhibit Escherichia coli ATP synthase in a differential manner.
22484153	Steroids	2012	Toh MF et al.	Biological characterization of non-steroidal progestins from botanicals used for women's health.
19074529	Drug Metab. Dispos.	2009	Si D et al.	Mechanism of CYP2C9 inhibition by flavones and flavonols.
25058688	Chem. Biol. Interact.	2014	Isoda H et al.	Analysis of the erythroid differentiation effect of flavonoid apigenin on K562 human chronic leukemia cells.
23782265	Biochem. J.	2013	Wiejak J et al.	Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells.
22732730	J Ethnopharmacol	2012	de Souza MR et al.	Pharmacological basis for use of Lychnophora trichocarpha in gouty arthritis: anti-hyperuricemic and anti-inflammatory effects of its extract, fraction and constituents.
22491013	EMBO J.	2012	Jiang Y et al.	Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin.
21163339	Fitoterapia	2011	Chen SN et al.	Phytoconstituents from Vitex agnus-castus fruits.
20576813	Blood	2010	Shehata M et al.	Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia.
20457805	Plant Physiol.	2010	Agne B et al.	The acidic A-domain of Arabidopsis TOC159 occurs as a hyperphosphorylated protein.
17541025	Arterioscler. Thromb. Vasc. Biol.	2007	Wenzel P et al.	Heme oxygenase-1: a novel key player in the development of tolerance in response to organic nitrates.
16954429	Endocr. Relat. Cancer	2006	Singh RP and Agarwal R	Mechanisms of action of novel agents for prostate cancer chemoprevention.
16781454	Free Radic. Biol. Med.	2006	Kachadourian R and Day BJ	Flavonoid-induced glutathione depletion: potential implications for cancer treatment.
16687488	Mol. Cancer Res.	2006	Ahmad KA et al.	Intracellular hydrogen peroxide production is an upstream event in apoptosis induced by down-regulation of casein kinase 2 in prostate cancer cells.
16400007	Am. J. Pathol.	2006	Sawatzky DA et al.	The involvement of the apoptosis-modulating proteins ERK 1/2, Bcl-xL and Bax in the resolution of acute inflammation in vivo.
12975498	J. Pharmacol. Exp. Ther.	2003	Wang H et al.	Up-regulation of endothelial nitric-oxide synthase by endothelium-derived hyperpolarizing factor involves mitogen-activated protein kinase and protein kinase C signaling pathways.
12788225	Biochim. Biophys. Acta	2003	Kim K et al.	Galectin-3 expression in macrophages is signaled by Ras/MAP kinase pathway and up-regulated by modified lipoproteins.
11807000	Blood	2002	Lorentz A et al.	Regulatory effects of stem cell factor and interleukin-4 on adhesion of human mast cells to extracellular matrix proteins.
27374313	EBioMedicine	2016	Feng X et al.	Activation of PPARγ by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization.
26526895	Int. J. Antimicrob. Agents	2015	Morimoto Y et al.	Apigenin as an anti-quinolone-resistance antibiotic.
26500281	Biosci. Rep.	2015	Seo HS et al.	Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells.
26475103	Appl. Environ. Microbiol.	2015	Xia F et al.	Combination Therapy of LysGH15 and Apigenin as a New Strategy for Treating Pneumonia Caused by Staphylococcus aureus.
26269546	Plant Physiol.	2015	Falcone Ferreyra ML et al.	The Identification of Maize and Arabidopsis Type I FLAVONE SYNTHASEs Links Flavones with Hormones and Biotic Interactions.
25965143	Redox Biol	2015	Banerjee K and Mandal M	Oxidative stress triggered by naturally occurring flavone apigenin results in senescence and chemotherapeutic effect in human colorectal cancer cells.
25799526	J. Surg. Res.	2015	Mrazek AA et al.	Apigenin inhibits pancreatic stellate cell activity in pancreatitis.
24837156	Bioorg. Med. Chem.	2014	Chen H et al.	Design, synthesis, and characterization of novel apigenin analogues that suppress pancreatic stellate cell proliferation in vitro and associated pancreatic fibrosis in vivo.