PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

References related to functions published in Others

PMID	Journal	Published Date	Author	Title
380688	Blood	1979	Cooper B	Diminished platelet adenylate cyclase activation by prostaglandin D2 in acute thrombosis.
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19429785	Development	2009	Moniot B et al.	The PGD2 pathway, independently of FGF9, amplifies SOX9 activity in Sertoli cells during male sexual differentiation.
20231490	Proc. Natl. Acad. Sci. U.S.A.	2010	Koharudin LM et al.	Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1.
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15889150	EMBO J.	2005	Malki S et al.	Prostaglandin D2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation.
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22707158	Cardiovasc. Res.	2012	Qiu H et al.	Cardiac-generated prostanoids mediate cardiac myocyte apoptosis after myocardial ischaemia.
24101660	Hypertension	2014	Filep JG	Glucocorticoid protection against myocardial ischemia-reperfusion injury: central role for the PGD2-Nrf2 pathway.
26941195	Plant Physiol.	2016	Hölscher C et al.	Defects in Peroxisomal 6-Phosphogluconate Dehydrogenase Isoform PGD2 Prevent Gametophytic Interaction in Arabidopsis thaliana.
27621415	J. Exp. Med.	2016	Kong D et al.	PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.
27091669	Allergol Int	2016	Kanai K et al.	Effect of prostaglandin D2 on VEGF release by nasal polyp fibroblasts.
26945085	J. Pharmacol. Exp. Ther.	2016	Nagira Y et al.	Prostaglandin D2 Modulates Neuronal Excitation of the Trigeminal Ganglion to Augment Allergic Rhinitis in Guinea Pigs.
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26916831	Mol. Pharmacol.	2016	Sykes DA et al.	Fevipiprant (QAW039), a Slowly Dissociating CRTh2 Antagonist with the Potential for Improved Clinical Efficacy.
26801686	Biochem. Pharmacol.	2016	Koyani CN et al.	Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ2-mediated cell death.
26777630	Biochim. Biophys. Acta	2016	Shirley D et al.	Resveratrol preferentially inhibits IgE-dependent PGD2 biosynthesis but enhances TNF production from human skin mast cells.
26429394	J. Steroid Biochem. Mol. Biol.	2016	Doig CL et al.	Knockdown of AKR1C3 exposes a potential epigenetic susceptibility in prostate cancer cells.
26032638	Biochem. Pharmacol.	2015	Cossette C et al.	Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes.
25323233	Eur. Respir. J.	2015	Maher SA et al.	Prostaglandin D2 and the role of the DP1, DP2 and TP receptors in the control of airway reflex events.
25269616	Reproduction	2015	Rossitto M et al.	Multiple roles of the prostaglandin D2 signaling pathway in reproduction.
25159329	Am. J. Physiol. Endocrinol. Metab.	2014	Cantley JL et al.	Targeting steroid receptor coactivator 1 with antisense oligonucleotides increases insulin-stimulated skeletal muscle glucose uptake in chow-fed and high-fat-fed male rats.
25140003	Mol. Pharmacol.	2014	Savinainen JR et al.	Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL).
25114172	J. Lipid Res.	2014	Dichlberger A et al.	Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells.
24698234	Int. J. Cardiol.	2014	Koyani CN et al.	15-deoxy-Δ¹²,¹⁴-PGJ₂ promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis.