propionic acid

propionic acid is a lipid of Fatty Acyls (FA) class. Propionic acid is associated with abnormalities such as Epilepsy, Infection, Tuberculosis, Alkalosis and Ischemia. The involved functions are known as Uptake, Biosynthetic Pathways, Methylation, Protein Overexpression and Biochemical Pathway. Propionic acid often locates in Body tissue, Cytoplasmic matrix, Membrane, Protoplasm and Extracellular. The associated genes with propionic acid are TRIO gene, TRRAP gene, SLC5A8 gene, SLC33A1 gene and Homologous Gene. The related lipids are Fatty Acids, Propionate, butyrate, Valerates and mycocerosic acid.

References related to functions published in Others

PMID	Journal	Published Date	Author	Title
8929440	J. Neurosci.	1996	Narasimhan P et al.	Methylmalonyl-CoA mutase induction by cerebral ischemia and neurotoxicity of the mitochondrial toxin methylmalonic acid.
9192785	Blood	1997	Matthews JH	Cyanocobalamin [c-lactam] inhibits vitamin B12 and causes cytotoxicity in HL60 cells: methionine protects cells completely.
9118502	Circulation	1997	Nofer JR et al.	Low-density lipoproteins inhibit the Na+/H+ antiport in human platelets. A novel mechanism enhancing platelet activity in hypercholesterolemia.
9868212	J. Nutr.	1998	Wedekind KJ and Lowry SR	Are organic zinc sources efficacious in puppies?
9915873	J. Nutr.	1999	Hara H et al.	Ingestion of guar gum hydrolysate, a soluble fiber, increases calcium absorption in totally gastrectomized rats.
10400451	Chem. Senses	1999	Robin O et al.	Basic emotions evoked by eugenol odor differ according to the dental experience. A neurovegetative analysis.
10222383	J. Nutr.	1999	Hara H et al.	Short-chain fatty acids suppress cholesterol synthesis in rat liver and intestine.
9649600	J. Nutr.	1998	Morita T et al.	Resistant proteins alter cecal short-chain fatty acid profiles in rats fed high amylose cornstarch.
10036254	J. Neurophysiol.	1999	Calupca MA et al.	Role of mitochondrial dysfunction in the Ca2+-induced decline of transmitter release at K+-depolarized motor neuron terminals.
10484494	Am. J. Physiol.	1999	Harada E et al.	Potentiation of carbachol-induced amylase release by propionate in guinea pig and vole pancreatic acini.
9887338	Hum. Mol. Genet.	1999	Campeau E et al.	Detection of a normally rare transcript in propionic acidemia patients with mRNA destabilizing mutations in the PCCA gene.
11179416	Mol. Biol. Cell	2001	Epstein CB et al.	Genome-wide responses to mitochondrial dysfunction.
11595672	Chem. Senses	2001	Youngentob SL et al.	Functional consequences following infection of the olfactory system by intranasal infusion of the olfactory bulb line variant (OBLV) of mouse hepatitis strain JHM.
11553740	Plant Physiol.	2001	Johannes E et al.	Cytoplasmic pH dynamics in maize pulvinal cells induced by gravity vector changes.
11514314	Am. J. Physiol. Heart Circ. Physiol.	2001	Carvalho RA et al.	TCA cycle kinetics in the rat heart by analysis of (13)C isotopomers using indirect (1)H.
11487650	J. Neurosci.	2001	Devaud JM et al.	Odor exposure causes central adaptation and morphological changes in selected olfactory glomeruli in Drosophila.
11470729	Am. J. Clin. Nutr.	2001	Darwiche G et al.	Measurements of the gastric emptying rate by use of ultrasonography: studies in humans using bread with added sodium propionate.
11914386	J. Exp. Biol.	2002	Fan Y et al.	Lipophorin-facilitated hydrocarbon uptake by oocytes in the German cockroach Blattella germanica (L.).
11807112	J. Exp. Biol.	2001	Krumschnabel G et al.	Regulation of intracellular pH in anoxia-tolerant and anoxia-intolerant teleost hepatocytes.
11369670	Chem. Senses	2001	Walker JC et al.	Human responses to propionic acid. II. Quantification of breathing responses and their relationship to perception.
12138140	J. Am. Soc. Nephrol.	2002	Cetinkaya I et al.	Inhibition of Na(+)-dependent transporters in cystine-loaded human renal cells: electrophysiological studies on the Fanconi syndrome of cystinosis.
11959947	Proc. Natl. Acad. Sci. U.S.A.	2002	Ebbing MH et al.	Resorcinarenes with 2-benzimidazolone bridges: self-aggregation, self-assembled dimeric capsules, and guest encapsulation.
12063291	Am. J. Physiol. Heart Circ. Physiol.	2002	Nomura N et al.	CaMKII-dependent reactivation of SR Ca(2+) uptake and contractile recovery during intracellular acidosis.
12364515	J. Neurophysiol.	2002	Jahromi SS et al.	Anticonvulsant actions of gap junctional blockers in an in vitro seizure model.
12421838	J. Nutr.	2002	Rodríguez-Cabezas ME et al.	Dietary fiber down-regulates colonic tumor necrosis factor alpha and nitric oxide production in trinitrobenzenesulfonic acid-induced colitic rats.
12409436	J. Clin. Microbiol.	2002	Bernard KA et al.	Characteristics of rare or recently described corynebacterium species recovered from human clinical material in Canada.
12819062	Infect. Immun.	2003	Sirakova TD et al.	The largest open reading frame (pks12) in the Mycobacterium tuberculosis genome is involved in pathogenesis and dimycocerosyl phthiocerol synthesis.
12677015	Stroke	2003	Santa N et al.	ATP-sensitive potassium channels mediate dilatation of basilar artery in response to intracellular acidification in vivo.
12711718	J. Neurophysiol.	2003	Johnson BN et al.	Rapid olfactory processing implicates subcortical control of an olfactomotor system.
12892112	Int. J. Syst. Evol. Microbiol.	2003	Wallace RJ et al.	Eubacterium pyruvativorans sp. nov., a novel non-saccharolytic anaerobe from the rumen that ferments pyruvate and amino acids, forms caproate and utilizes acetate and propionate.
12867486	Drug Metab. Dispos.	2003	Sprague CL and Elfarra AA	Detection of carboxylic acids and inhibition of hippuric acid formation in rats treated with 3-butene-1,2-diol, a major metabolite of 1,3-butadiene.
10564143	Am. J. Physiol.	1999	Leffler CW et al.	cAMP production by piglet cerebral vascular smooth muscle cells: pH(o), pH(i), and permissive action of PGI(2).
10648377	Arch. Dis. Child.	2000	Mellon AF et al.	Effect of oral antibiotics on intestinal production of propionic acid.
10794671	Am. J. Physiol., Cell Physiol.	2000	Maouyo D et al.	pH heterogeneity at intracellular and extracellular plasma membrane sites in HT29-C1 cell monolayers.
10749735	Am. J. Physiol. Heart Circ. Physiol.	2000	Spitzer KW et al.	Generation of intracellular pH gradients in single cardiac myocytes with a microperfusion system.
11005765	Am. J. Physiol. Gastrointest. Liver Physiol.	2000	Hadjiagapiou C et al.	Mechanism(s) of butyrate transport in Caco-2 cells: role of monocarboxylate transporter 1.
11007594	J. Appl. Physiol.	2000	Heming TA et al.	pH(i) responses to osmotic cell shrinkage in the presence of open-system buffers.
10667993	Chem. Senses	2000	Laska M et al.	'Microsmatic' primates revisited: olfactory sensitivity in the squirrel monkey.
9756546	Am. J. Physiol.	1998	Ritucci NA et al.	Intracellular pH regulation in neurons from chemosensitive and nonchemosensitive areas of the medulla.
9596720	Infect. Immun.	1998	Kurita-Ochiai T et al.	Volatile fatty acid, metabolic by-product of periodontopathic bacteria, induces apoptosis in WEHI 231 and RAJI B lymphoma cells and splenic B cells.
14722361	Proc. Natl. Acad. Sci. U.S.A.	2004	Xiong Y et al.	Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.
15143048	Int. J. Syst. Evol. Microbiol.	2004	Abou-Zeid DM et al.	Propionispora hippei sp. nov., a novel Gram-negative, spore-forming anaerobe that produces propionic acid.
19264953	Am. J. Physiol. Gastrointest. Liver Physiol.	2009	Aschenbach JR et al.	Bicarbonate-dependent and bicarbonate-independent mechanisms contribute to nondiffusive uptake of acetate in the ruminal epithelium of sheep.
19508502	FEMS Microbiol. Ecol.	2009	Grootaert C et al.	Comparison of prebiotic effects of arabinoxylan oligosaccharides and inulin in a simulator of the human intestinal microbial ecosystem.
19553547	J. Immunol.	2009	Andresen L et al.	Propionic acid secreted from propionibacteria induces NKG2D ligand expression on human-activated T lymphocytes and cancer cells.
19625534	J. Neurophysiol.	2009	Dulla CG et al.	Intracellular acidification causes adenosine release during states of hyperexcitability in the hippocampus.
14519799	J. Nutr.	2003	Vogt JA and Wolever TM	Fecal acetate is inversely related to acetate absorption from the human rectum and distal colon.
21750241	Eur J Orthod	2012	Silvestrini-Biavati A et al.	In vitro determination of the mechanical and chemical properties of a fibre orthodontic retainer.
17360366	Proc. Natl. Acad. Sci. U.S.A.	2007	Jain M et al.	Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling.
17625181	Int. J. Syst. Evol. Microbiol.	2007	Imachi H et al.	Pelotomaculum propionicicum sp. nov., an anaerobic, mesophilic, obligately syntrophic, propionate-oxidizing bacterium.
14985418	J. Pharmacol. Exp. Ther.	2004	Christensen JK et al.	In vitro characterization of 5-carboxyl-2,4-di-benzamidobenzoic acid (NS3763), a noncompetitive antagonist of GLUK5 receptors.
16627667	Int. J. Syst. Evol. Microbiol.	2006	Vandieken V et al.	Desulfuromonas svalbardensis sp. nov. and Desulfuromusa ferrireducens sp. nov., psychrophilic, Fe(III)-reducing bacteria isolated from Arctic sediments, Svalbard.
16772459	J. Nutr.	2006	Bradford BJ et al.	Propionate challenge tests have limited value for investigating bovine metabolism.
23401498	Proc. Natl. Acad. Sci. U.S.A.	2013	Pluznick JL et al.	Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation.
23814018	Blood	2013	Tung S et al.	PPARα and fatty acid oxidation mediate glucocorticoid resistance in chronic lymphocytic leukemia.
23365194	J R Soc Interface	2013	Kojadinovic M et al.	Response kinetics in the complex chemotaxis signalling pathway of Rhodobacter sphaeroides.