Lipoxin A4

Lipoxin a4 is a lipid of Fatty Acyls (FA) class. Lipoxin a4 is associated with abnormalities such as Asthma, Cystic Fibrosis, Pneumonia, Obesity and Septicemia. The involved functions are known as Inflammation, Signal, Signal Transduction, Regulation and Metabolic Inhibition. Lipoxin a4 often locates in Immune system, Blood, soluble, Extracellular and Splenic Tissue. The associated genes with Lipoxin A4 are FPR2 gene, Homologous Gene, SAA1 gene, Trp-Lys-Tyr-Met-Val-Met and Annexin 1. The related lipids are Steroids. The related experimental models are Knock-out.

References related to functions published in Others

PMID	Journal	Published Date	Author	Title
11818541	Proc. Natl. Acad. Sci. U.S.A.	2002	Resnati M et al.	The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R.
12920210	Mol. Pharmacol.	2003	Bae YS et al.	Differential signaling of formyl peptide receptor-like 1 by Trp-Lys-Tyr-Met-Val-Met-CONH2 or lipoxin A4 in human neutrophils.
21220563	Invest. Ophthalmol. Vis. Sci.	2011	Kenchegowda S et al.	EGF stimulates lipoxin A4 synthesis and modulates repair in corneal epithelial cells through ERK and p38 activation.
23319805	Cancer Res.	2013	Wang C et al.	IFN-γ-mediated downregulation of LXA4 is necessary for the maintenance of nonresolving inflammation and papilloma persistence.
23520204	J. Am. Soc. Nephrol.	2013	Brennan EP et al.	Lipoxins attenuate renal fibrosis by inducing let-7c and suppressing TGFβR1.
24820086	Antimicrob. Agents Chemother.	2014	Fischer CD et al.	Tulathromycin exerts proresolving effects in bovine neutrophils by inhibiting phospholipases and altering leukotriene B4, prostaglandin E2, and lipoxin A4 production.
24696116	Eur. Respir. J.	2014	Ringholz FC et al.	Reduced 15-lipoxygenase 2 and lipoxin A4/leukotriene B4 ratio in children with cystic fibrosis.
27993857	Antimicrob. Agents Chemother.	2017	González-Herrera F et al.	Simvastatin Attenuates Endothelial Activation through 15-Epi-Lipoxin A4 Production in Murine Chronic Chagas Cardiomyopathy.
26732571	Stroke	2016	Guo Z et al.	Lipoxin A4 Reduces Inflammation Through Formyl Peptide Receptor 2/p38 MAPK Signaling Pathway in Subarachnoid Hemorrhage Rats.
25342661	Blood	2014	Zimring JC	The fat and the skinny on acute lung injury.
25143486	Blood	2014	Ortiz-Muñoz G et al.	Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.