hypericin
hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
References related to functions published in Others
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 11158749 | Antimicrob. Agents Chemother. | 2001 | Jacobson JM et al. | Pharmacokinetics, safety, and antiviral effects of hypericin, a derivative of St. John's wort plant, in patients with chronic hepatitis C virus infection. |
| 14678981 | Cancer Res. | 2003 | Blank M et al. | Enhanced ubiquitinylation of heat shock protein 90 as a potential mechanism for mitotic cell death in cancer cells induced with hypericin. |
| 21498539 | J. Nucl. Med. | 2011 | Song S et al. | Small-animal PET of tumor damage induced by photothermal ablation with 64Cu-bis-DOTA-hypericin. |
| 20551295 | J. Pharmacol. Exp. Ther. | 2010 | Wang X et al. | Cellular and molecular mechanisms of photodynamic hypericin therapy for nasopharyngeal carcinoma cells. |
| 15640377 | Drug Metab. Dispos. | 2005 | Tian R et al. | Functional induction and de-induction of P-glycoprotein by St. John's wort and its ingredients in a human colon adenocarcinoma cell line. |
| 16891333 | Ann. Bot. | 2006 | Zobayed SM et al. | Plant-environment interactions: Accumulation of hypericin in dark glands of Hypericum perforatum. |
| 16615212 | Proc. Biol. Sci. | 2006 | Wolkenstein K et al. | Preservation of hypericin and related polycyclic quinone pigments in fossil crinoids. |
| 18156139 | Eur. Heart J. | 2008 | Fonge H et al. | Non-invasive detection and quantification of acute myocardial infarction in rabbits using mono-[123I]iodohypericin microSPECT. |
| 22198320 | Biochim. Biophys. Acta | 2012 | Richard AJ et al. | St. John's Wort inhibits insulin signaling in murine and human adipocytes. |