Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

References related to functions published in Others

PMID	Journal	Published Date	Author	Title
10642557	Biol. Reprod.	2000	Dabrowski K et al.	Effects of diets containing gossypol on reproductive capacity of rainbow trout (Oncorhynchus mykiss).
10829068	Proc. Natl. Acad. Sci. U.S.A.	2000	Heiser V et al.	Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy.
19228717	Clin. Cancer Res.	2009	Kang MH and Reynolds CP	Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy.
19528479	Anticancer Res.	2009	Huang YW et al.	(-)-Gossypol reduces invasiveness in metastatic prostate cancer cells.
20587533	Mol. Cancer Res.	2010	Voss V et al.	The pan-Bcl-2 inhibitor (-)-gossypol triggers autophagic cell death in malignant glioma.
20032412	Anticancer Res.	2009	Xu P et al.	Mitogenic activity of zeranol in human breast cancer cells is enhanced by leptin and suppressed by gossypol.
15570010	Clin. Cancer Res.	2004	Oliver CL et al.	In vitro effects of the BH3 mimetic, (-)-gossypol, on head and neck squamous cell carcinoma cells.
15621416	FEMS Microbiol. Lett.	2005	Weissenmayer B et al.	The calcineurin inhibitor gossypol impairs growth, cell signalling and development in Dictyostelium discoideum.
15849309	Plant Physiol.	2005	Townsend BJ et al.	Antisense suppression of a (+)-delta-cadinene synthase gene in cotton prevents the induction of this defense response gene during bacterial blight infection but not its constitutive expression.
16935937	FASEB J.	2006	Lei X et al.	Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2.
17162530	Toxicol Pathol	2006	de Andrade SF et al.	Epididymis-specific pathologic disorders in rats exposed to gossypol from weaning through puberty.
17110445	Proc. Natl. Acad. Sci. U.S.A.	2006	Sunilkumar G et al.	Engineering cottonseed for use in human nutrition by tissue-specific reduction of toxic gossypol.
22525702	Cancer Res.	2012	Mazumder S et al.	Mcl-1 Phosphorylation defines ABT-737 resistance that can be overcome by increased NOXA expression in leukemic B cells.
22466256	Mol. Cancer Res.	2012	Billard C	Development of Noxa-like BH3 mimetics for apoptosis-based therapeutic strategy in chronic lymphocytic leukemia.
22158856	Cancer Res.	2012	Imai A et al.	Metronomic dosing of BH3 mimetic small molecule yields robust antiangiogenic and antitumor effects.
26721623	Biochim. Biophys. Acta	2016	Antonietti P et al.	AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy irrespective of expression levels and the subcellular localization of Bcl-xL and Bcl-2 in MCF7 cells.
26408551	Am. J. Physiol. Lung Cell Mol. Physiol.	2015	Kottmann RM et al.	Pharmacologic inhibition of lactate production prevents myofibroblast differentiation.
26254422	Am. J. Physiol. Lung Cell Mol. Physiol.	2015	Judge JL et al.	Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase.
25802279	Mol. Cell. Biol.	2015	Hanus J et al.	Gossypol Acetic Acid Prevents Oxidative Stress-Induced Retinal Pigment Epithelial Necrosis by Regulating the FoxO3/Sestrin2 Pathway.