Glycyrrhetinic acid

Glycyrrhetinic acid is a lipid of Prenol Lipids (PR) class. Glycyrrhetinic acid is associated with abnormalities such as Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency, Hypertensive disease, Mineralocorticoid Excess Syndrome, Apparent and Syndrome. The involved functions are known as Signal, Muscle Contraction, Pressure- physical agent, Agent and Metabolic Inhibition. Glycyrrhetinic acid often locates in Protoplasm, Body tissue, Muscle, Connexon and Extracellular. The associated genes with Glycyrrhetinic acid are SLC33A1 gene, GJB1 gene, RNU1-1 gene, HADHA gene and RNU1-4 gene. The related lipids are Steroids, Saponin, Octanols, Heptanol and amyrin.

References related to functions published in Others

PMID	Journal	Published Date	Author	Title
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18787080	Reproduction	2008	Webb RJ et al.	Inactivation of glucocorticoids by 11beta-hydroxysteroid dehydrogenase enzymes increases during the meiotic maturation of porcine oocytes.
22277757	Am. J. Physiol., Cell Physiol.	2012	Niger C et al.	ERK acts in parallel to PKCδ to mediate the connexin43-dependent potentiation of Runx2 activity by FGF2 in MC3T3 osteoblasts.
22461022	Am. J. Physiol. Gastrointest. Liver Physiol.	2012	Carbone SE et al.	Loss of responsiveness of circular smooth muscle cells from the guinea pig ileum is associated with changes in gap junction coupling.
22492652	Am. J. Physiol., Cell Physiol.	2012	Shahidullah M et al.	TRPV4 in porcine lens epithelium regulates hemichannel-mediated ATP release and Na-K-ATPase activity.
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25100592	J. Neurosci.	2014	Akopian A et al.	Gap junction-mediated death of retinal neurons is connexin and insult specific: a potential target for neuroprotection.
21144857	Front Neuroendocrinol	2011	Wyrwoll CS et al.	11β-hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress.
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12911547	Kidney Int.	2003	Lanz B et al.	Angiotensin II regulates 11beta-hydroxysteroid dehydrogenase type 2 via AT2 receptors.
27626200	Cell Metab.	2016	Zhu Y et al.	Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals.
27373856	Pharmacol. Ther.	2016	Ikarashi Y and Mizoguchi K	Neuropharmacological efficacy of the traditional Japanese Kampo medicine yokukansan and its active ingredients.