ursolic acid

Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.

References related to functions published in Others


PMIDJournalPublished DateAuthorTitle
16000817Appl. Environ. Microbiol.2005Ren D et al.Differential gene expression for investigation of Escherichia coli biofilm inhibition by plant extract ursolic acid.
17855663Mol. Cancer Res.2007Pathak AK et al.Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells.
22551965Eur J Cardiothorac Surg2012Zeller I et al.Inhibition of cell surface expression of endothelial adhesion molecules by ursolic acid prevents intimal hyperplasia of venous bypass grafts in rats.
22869743Proc. Natl. Acad. Sci. U.S.A.2012Crown PL et al.Ritual Black Drink consumption at Cahokia.
22832932Clin. Cancer Res.2012Prasad S et al.Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.
21586682Plant Cell2011Martin C et al.How can research on plants contribute to promoting human health?
26100520Cancer Prev Res (Phila)2015Cho J et al.Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.
27063951J. Lipid Res.2016Leng S et al.Ursolic acid enhances macrophage autophagy and attenuates atherogenesis.
25861934Eur. J. Pharmacol.2015Colla AR et al.Anxiolytic-like effects of ursolic acid in mice.
25617694Eur J Med Chem2015Chen H et al.Evolution in medicinal chemistry of ursolic acid derivatives as anticancer agents.
25312987Biochim. Biophys. Acta2015Castro AJ et al.The mechanism of action of ursolic acid as insulin secretagogue and insulinomimetic is mediated by cross-talk between calcium and kinases to regulate glucose balance.
24494201Redox Biol2014Ullevig SL et al.Ursolic acid protects monocytes against metabolic stress-induced priming and dysfunction by preventing the induction of Nox4.