Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
PMID | Journal | Published Date | Author | Title |
---|---|---|---|---|
16751413 | J. Immunol. | 2006 | Morimoto K et al. | Lovastatin enhances clearance of apoptotic cells (efferocytosis) with implications for chronic obstructive pulmonary disease. |
9218793 | EMBO J. | 1997 | Reggiori F et al. | Lipid remodeling leads to the introduction and exchange of defined ceramides on GPI proteins in the ER and Golgi of Saccharomyces cerevisiae. |
9582276 | EMBO J. | 1998 | Meyer zu Heringdorf D et al. | Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors. |
9915902 | J. Nutr. | 1999 | Wang E et al. | Fumonisin B1 consumption by rats causes reversible, dose-dependent increases in urinary sphinganine and sphingosine. |
10523394 | Hypertension | 1999 | Touyz RM and Schiffrin EL | Ang II-stimulated superoxide production is mediated via phospholipase D in human vascular smooth muscle cells. |
11238696 | J. Natl. Cancer Inst. | 2001 | Senchenkov A et al. | Targeting ceramide metabolism--a strategy for overcoming drug resistance. |
11584099 | J. Nutr. | 2001 | Abnet CC et al. | A cross-sectional study of human serum sphingolipids, diet and physiologic parameters. |
11387200 | EMBO J. | 2001 | Guillas I et al. | C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p. |
11431347 | Cancer Res. | 2001 | Wang H et al. | N-(4-hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase. |
12482970 | Mol. Cell. Biol. | 2003 | Cheng J et al. | Induction of apoptosis by sphingoid long-chain bases in Aspergillus nidulans. |
10781105 | Proc. Natl. Acad. Sci. U.S.A. | 2000 | Brandwagt BF et al. | A longevity assurance gene homolog of tomato mediates resistance to Alternaria alternata f. sp. lycopersici toxins and fumonisin B1. |
11106681 | J. Natl. Cancer Inst. | 2000 | Maurer BJ et al. | Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism. |
10856228 | EMBO J. | 2000 | Zanolari B et al. | Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae. |
9804619 | Mol. Pharmacol. | 1998 | Jarvis WD et al. | Evidence for involvement of mitogen-activated protein kinase, rather than stress-activated protein kinase, in potentiation of 1-beta-D-arabinofuranosylcytosine-induced apoptosis by interruption of protein kinase C signaling. |
15289350 | Cancer Res. | 2004 | Batra S et al. | Fenretinide cytotoxicity for Ewing's sarcoma and primitive neuroectodermal tumor cell lines is decreased by hypoxia and synergistically enhanced by ceramide modulators. |
15229289 | Mol. Biol. Cell | 2004 | Van IJzendoorn SC et al. | Polarized membrane traffic and cell polarity development is dependent on dihydroceramide synthase-regulated sphinganine turnover. |
14724218 | J. Pharmacol. Exp. Ther. | 2004 | Johnson CR et al. | Intrinsic cytotoxicity and chemomodulatory actions of novel phenethylisothiocyanate sphingoid base derivatives in HL-60 human promyelocytic leukemia cells. |
21257722 | Clin. Cancer Res. | 2011 | Dickson MA et al. | A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors. |
17609357 | J. Vet. Diagn. Invest. | 2007 | Hsiao SH et al. | Use of formalin-fixed tissues to determine fumonisin B1-induced sphingolipid alterations in swine. |
18362204 | FASEB J. | 2008 | Gude DR et al. | Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal. |
15545514 | Circulation | 2004 | Park TS et al. | Inhibition of sphingomyelin synthesis reduces atherogenesis in apolipoprotein E-knockout mice. |
15550678 | Mol. Pharmacol. | 2005 | Grimm C et al. | Activation of the melastatin-related cation channel TRPM3 by D-erythro-sphingosine [corrected]. |
18599698 | Int. J. Syst. Evol. Microbiol. | 2008 | Matsuyama H et al. | Sphingobacterium kitahiroshimense sp. nov., isolated from soil. |
22354293 | Antimicrob. Agents Chemother. | 2012 | Vandenbosch D et al. | Phytosphingosine-1-phosphate is a signaling molecule involved in miconazole resistance in sessile Candida albicans cells. |
22872679 | FASEB J. | 2012 | Ashkenazi A et al. | Sphingopeptides: dihydrosphingosine-based fusion inhibitors against wild-type and enfuvirtide-resistant HIV-1. |
23143542 | Eur. Respir. J. | 2013 | Tibboel J et al. | Amelioration of hyperoxia-induced lung injury using a sphingolipid-based intervention. |
22345606 | Genetics | 2012 | Henry SA et al. | Metabolism and regulation of glycerolipids in the yeast Saccharomyces cerevisiae. |
26378098 | Plant Physiol. | 2015 | Magnin-Robert M et al. | Modifications of Sphingolipid Content Affect Tolerance to Hemibiotrophic and Necrotrophic Pathogens by Modulating Plant Defense Responses in Arabidopsis. |
16126159 | Biochim. Biophys. Acta | 2005 | Alanko SM et al. | Displacement of sterols from sterol/sphingomyelin domains in fluid bilayer membranes by competing molecules. |
12479368 | Mol. Cancer Ther. | 2002 | Wang H et al. | Enhanced de novo ceramide generation through activation of serine palmitoyltransferase by the P-glycoprotein antagonist SDZ PSC 833 in breast cancer cells. |
21421810 | Plant Cell | 2011 | Chao DY et al. | Sphingolipids in the root play an important role in regulating the leaf ionome in Arabidopsis thaliana. |
21119626 | Mol. Syst. Biol. | 2010 | Gallego O et al. | A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae. |
20599536 | Biochem. Biophys. Res. Commun. | 2010 | Monette JS et al. | Characteristics of the rat cardiac sphingolipid pool in two mitochondrial subpopulations. |
20160710 | Mol. Syst. Biol. | 2010 | Cowart LA et al. | Revealing a signaling role of phytosphingosine-1-phosphate in yeast. |
19393694 | Biochim. Biophys. Acta | 2009 | Sridevi P et al. | Ceramide synthase 1 is regulated by proteasomal mediated turnover. |
19285059 | Eur. J. Pharmacol. | 2009 | Ramachandran S et al. | The sigma1 receptor interacts with N-alkyl amines and endogenous sphingolipids. |
18414484 | Mol. Syst. Biol. | 2008 | Garcia J et al. | Mathematical modeling of pathogenicity of Cryptococcus neoformans. |
16987101 | Biochem. J. | 2007 | Cerantola V et al. | Yeast sphingolipids do not need to contain very long chain fatty acids. |
15665242 | Plant Physiol. | 2005 | Coursol S et al. | Arabidopsis sphingosine kinase and the effects of phytosphingosine-1-phosphate on stomatal aperture. |
12742826 | Am. J. Physiol. Heart Circ. Physiol. | 2003 | Constable PD et al. | Fumonisin-induced blockade of ceramide synthase in sphingolipid biosynthetic pathway alters aortic input impedance spectrum of pigs. |
26277409 | Biochim. Biophys. Acta | 2015 | Megson ZA et al. | Inositol-phosphodihydroceramides in the periodontal pathogen Tannerella forsythia: Structural analysis and incorporation of exogenous myo-inositol. |
26264277 | Mol. Cancer Ther. | 2015 | Tsukamoto S et al. | Sphingosine Kinase-1 Protects Multiple Myeloma from Apoptosis Driven by Cancer-Specific Inhibition of RTKs. |