phytosphingosine
phytosphingosine is a lipid of Sphingolipids (SP) class. Phytosphingosine is associated with abnormalities such as Infection, Nodule, Dehydration, Neuropathy and nervous system disorder. The involved functions are known as Saturated, sphingomyelin synthase activity, Heat-Shock Response, Cell Growth and Apoptosis. Phytosphingosine often locates in Clone, Protoplasm, Mitochondria, soluble and Cytoplasmic matrix. The associated genes with phytosphingosine are SGMS1 gene, BCL2 gene, Chromatin, Homologous Gene and DLEU2 gene. The related lipids are Sphingolipids, inositolphosphorylceramide, Phosphatidylserines, dihydroceramide and Fatty Acids. The related experimental models are Knock-out.
References related to functions published in Others
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 11726514 | EMBO J. | 2001 | Friant S et al. | Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast. |
| 12576463 | Clin. Cancer Res. | 2003 | Park MT et al. | Phytosphingosine induces apoptotic cell death via caspase 8 activation and Bax translocation in human cancer cells. |
| 20030721 | FEMS Microbiol. Lett. | 2010 | Thevissen K et al. | Skn1 and Ipt1 negatively regulate autophagy in Saccharomyces cerevisiae. |
| 17600137 | Plant Physiol. | 2007 | Ryan PR et al. | A higher plant delta8 sphingolipid desaturase with a preference for (Z)-isomer formation confers aluminum tolerance to yeast and plants. |
| 18248300 | J. Infect. Dis. | 2008 | Amemiya F et al. | Targeting lipid metabolism in the treatment of hepatitis C virus infection. |
| 15486061 | Blood | 2005 | Park MT et al. | Phytosphingosine in combination with ionizing radiation enhances apoptotic cell death in radiation-resistant cancer cells through ROS-dependent and -independent AIF release. |
| 16879426 | FEMS Yeast Res. | 2006 | Yang Z et al. | Identification of mouse sphingomyelin synthase 1 as a suppressor of Bax-mediated cell death in yeast. |
| 17237268 | Mol. Cancer Ther. | 2007 | Park MT et al. | Combination treatment with arsenic trioxide and phytosphingosine enhances apoptotic cell death in arsenic trioxide-resistant cancer cells. |
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| 21421810 | Plant Cell | 2011 | Chao DY et al. | Sphingolipids in the root play an important role in regulating the leaf ionome in Arabidopsis thaliana. |
| 27561298 | J. Lipid Res. | 2016 | Martínez-Montañés F et al. | Accumulation of long-chain bases in yeast promotes their conversion to a long-chain base vinyl ether. |
| 21376639 | Immunity | 2011 | Wun KS et al. | A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells. |
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| 19538930 | Immunity | 2009 | Im JS et al. | Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation. |
| 15665242 | Plant Physiol. | 2005 | Coursol S et al. | Arabidopsis sphingosine kinase and the effects of phytosphingosine-1-phosphate on stomatal aperture. |
| 17070498 | Biochim. Biophys. Acta | 2006 | Goñi FM and Alonso A | Biophysics of sphingolipids I. Membrane properties of sphingosine, ceramides and other simple sphingolipids. |
| 12164940 | J. Invest. Dermatol. | 2002 | Macheleidt O et al. | Deficiency of epidermal protein-bound omega-hydroxyceramides in atopic dermatitis. |