Tetradecanoic acid

Tetradecanoic acid is a lipid of Fatty Acyls (FA) class. Tetradecanoic acid is associated with abnormalities such as Chronic lung disease, Infection, Spastic syndrome, Diabetes and Cardiovascular Diseases. The involved functions are known as Fatty acid biosynthetic process, Anabolism, lung alveolus development, 5-(carboxyamino)imidazole ribonucleotide mutase activity and Homeostasis. Tetradecanoic acid often locates in Structure of parenchyma of lung, Blood, Head, Membrane and Cytoplasmic matrix. The associated genes with Tetradecanoic acid are SLC33A1 gene, SFTPA1 gene, P4HTM gene, Polypeptides and GPR132 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, palmitoleic acid, Phosphatidylglycerols and Butanols.

References related to functions published in Others

PMID	Journal	Published Date	Author	Title
9436987	Mol. Biol. Cell	1998	Morales J et al.	Plasma membrane localization of G alpha z requires two signals.
9103475	J. Pharmacol. Exp. Ther.	1997	Naze S et al.	Activation of phospholipase D by endothelin-1 in rat myometrium. Role of calcium and protein kinase C.
10205160	EMBO J.	1999	Godsel LM and Engman DM	Flagellar protein localization mediated by a calcium-myristoyl/palmitoyl switch mechanism.
9611229	Nucleic Acids Res.	1998	Cok SJ et al.	Transcription of INO2 and INO4 is regulated by the state of protein N-myristoylation in Saccharomyces cerevisiae.
11713268	Mol. Cell. Biol.	2001	Kovárová M et al.	Structure-function analysis of Lyn kinase association with lipid rafts and initiation of early signaling events after Fcepsilon receptor I aggregation.
11891256	Plant Physiol.	2002	Lu SX and Hrabak EM	An Arabidopsis calcium-dependent protein kinase is associated with the endoplasmic reticulum.
12118067	J. Cell. Sci.	2002	Navarro-Lérida I et al.	Distance-dependent cellular palmitoylation of de-novo-designed sequences and their translocation to plasma membrane subdomains.
12829627	Diabetes	2003	Mittendorfer B et al.	What does the measurement of whole-body fatty acid rate of appearance in plasma by using a fatty acid tracer really mean?
12455958	Eukaryotic Cell	2002	Shaw BD et al.	Aspergillus nidulans swoF encodes an N-myristoyl transferase.
12372805	Am. J. Physiol., Cell Physiol.	2002	Clarke AL et al.	Modulation of BK(Ca) channel activity by fatty acids: structural requirements and mechanism of action.
12874217	J. Immunol.	2003	Na SY et al.	Constitutively active protein kinase B enhances Lck and Erk activities and influences thymocyte selection and activation.
10564270	Mol. Biol. Cell	1999	McCabe JB and Berthiaume LG	Functional roles for fatty acylated amino-terminal domains in subcellular localization.
11035106	J. Immunol.	2000	Monick MM et al.	Protein kinase C zeta plays a central role in activation of the p42/44 mitogen-activated protein kinase by endotoxin in alveolar macrophages.
11099414	Science	2000	Zha J et al.	Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis.
11006339	Plant Cell	2000	Ishitani M et al.	SOS3 function in plant salt tolerance requires N-myristoylation and calcium binding.
10974060	J. Lipid Res.	2000	Bodennec J et al.	A procedure for fractionation of sphingolipid classes by solid-phase extraction on aminopropyl cartridges.
10975838	J. Immunol.	2000	Yasuda K et al.	Serine 6 of Lck tyrosine kinase: a critical site for Lck myristoylation, membrane localization, and function in T lymphocytes.
10921902	Genes Dev.	2000	Ashrafi K et al.	Sip2p and its partner snf1p kinase affect aging in S. cerevisiae.
14576428	Science	2003	Hanczyc MM et al.	Experimental models of primitive cellular compartments: encapsulation, growth, and division.
14532054	Appl. Environ. Microbiol.	2003	Eschenfeldt WH et al.	Transformation of fatty acids catalyzed by cytochrome P450 monooxygenase enzymes of Candida tropicalis.
15302818	Eukaryotic Cell	2004	Paul KS et al.	Multiple triclosan targets in Trypanosoma brucei.
15126327	Cancer Res.	2004	Uno F et al.	Myristoylation of the fus1 protein is required for tumor suppression in human lung cancer cells.
21636561	J. Appl. Physiol.	2011	Bernhard W et al.	Increased palmitoyl-myristoyl-phosphatidylcholine in neonatal rat surfactant is lung specific and correlates with oral myristic acid supply.
21653836	J. Immunol.	2011	Morita D et al.	Cutting edge: T cells monitor N-myristoylation of the Nef protein in simian immunodeficiency virus-infected monkeys.
20811010	Am. J. Physiol. Regul. Integr. Comp. Physiol.	2010	Pynn CJ et al.	Myristate is selectively incorporated into surfactant and decreases dipalmitoylphosphatidylcholine without functional impairment.
19955401	Am. J. Clin. Nutr.	2010	Bradbury KE et al.	The serum fatty acids myristic acid and linoleic acid are better predictors of serum cholesterol concentrations when measured as molecular percentages rather than as absolute concentrations.
20584982	Mol. Cell. Biol.	2010	Patwardhan P and Resh MD	Myristoylation and membrane binding regulate c-Src stability and kinase activity.
17616681	Cancer Res.	2007	Adam RM et al.	Cholesterol sensitivity of endogenous and myristoylated Akt.
15687105	J. Cell. Sci.	2005	Price HP et al.	Functional analysis of TbARL1, an N-myristoylated Golgi protein essential for viability in bloodstream trypanosomes.
16569659	J. Cell. Sci.	2006	Navarro-Lérida I et al.	N-terminal palmitoylation within the appropriate amino acid environment conveys on NOS2 the ability to progress along the intracellular sorting pathways.
16476977	J. Gen. Virol.	2006	Bentham M et al.	Role of myristoylation and N-terminal basic residues in membrane association of the human immunodeficiency virus type 1 Nef protein.
17197513	Invest. Ophthalmol. Vis. Sci.	2007	Nichols KK et al.	Identification of fatty acids and fatty acid amides in human meibomian gland secretions.
21965604	FASEB J.	2012	Martin DD et al.	Tandem reporter assay for myristoylated proteins post-translationally (TRAMPP) identifies novel substrates for post-translational myristoylation: PKCε, a case study.
22391103	Mol. Pharmacol.	2012	Puhl AC et al.	Mode of peroxisome proliferator-activated receptor γ activation by luteolin.
20851587	Phytomedicine	2011	Waltenberger B et al.	Predicting cyclooxygenase inhibition by three-dimensional pharmacophoric profiling. Part II: Identification of enzyme inhibitors from Prasaplai, a Thai traditional medicine.
20971967	Diabetes	2011	Elsner M et al.	Peroxisome-generated hydrogen peroxide as important mediator of lipotoxicity in insulin-producing cells.
19357638	Mol. Syst. Biol.	2009	Atherton HJ et al.	Metabolomics of the interaction between PPAR-alpha and age in the PPAR-alpha-null mouse.
22345606	Genetics	2012	Henry SA et al.	Metabolism and regulation of glycerolipids in the yeast Saccharomyces cerevisiae.
22085962	Genes Dev.	2011	Wright KJ et al.	An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium.
22000011	Cell	2011	Grebien F et al.	Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis.
21820081	Biochim. Biophys. Acta	2011	Grillitsch K et al.	Lipid particles/droplets of the yeast Saccharomyces cerevisiae revisited: lipidome meets proteome.
21382489	Biochim. Biophys. Acta	2011	Varga T et al.	PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation.
20940056	J. Struct. Biol.	2011	Ryan AJ et al.	Structural basis of binding of fluorescent, site-specific dansylated amino acids to human serum albumin.
20805277	Diabetes Care	2010	Chen X et al.	Differences in maternal circulating fatty acid composition and dietary fat intake in women with gestational diabetes mellitus or mild gestational hyperglycemia.
20534735	Plant Physiol.	2010	Brechenmacher L et al.	Soybean metabolites regulated in root hairs in response to the symbiotic bacterium Bradyrhizobium japonicum.
20045147	Metab. Clin. Exp.	2010	Lemaitre RN et al.	Endogenous red blood cell membrane fatty acids and sudden cardiac arrest.
20036251	J. Mol. Biol.	2010	Brannigan JA et al.	N-myristoyltransferase from Leishmania donovani: structural and functional characterisation of a potential drug target for visceral leishmaniasis.
19934003	Diabetes	2010	Yeop Han C et al.	Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes: dissociation of adipocyte hypertrophy from inflammation.
18657545	J. Mol. Biol.	2008	Saad JS et al.	Structure of the myristylated human immunodeficiency virus type 2 matrix protein and the role of phosphatidylinositol-(4,5)-bisphosphate in membrane targeting.
18398033	Cancer Epidemiol. Biomarkers Prev.	2008	Kurahashi N et al.	Dairy product, saturated fatty acid, and calcium intake and prostate cancer in a prospective cohort of Japanese men.
18068687	Biochem. Pharmacol.	2008	Isenberg JS et al.	Differential effects of ABT-510 and a CD36-binding peptide derived from the type 1 repeats of thrombospondin-1 on fatty acid uptake, nitric oxide signaling, and caspase activation in vascular cells.
17932026	FASEB J.	2008	Martin DD et al.	Rapid detection, discovery, and identification of post-translationally myristoylated proteins during apoptosis using a bio-orthogonal azidomyristate analog.
17551510	Mol. Syst. Biol.	2007	Smith JJ et al.	Transcriptional responses to fatty acid are coordinated by combinatorial control.
17169445	Mol. Biochem. Parasitol.	2007	Mills E et al.	Kinetoplastid PPEF phosphatases: dual acylated proteins expressed in the endomembrane system of Leishmania.
16123142	Mol. Cancer Res.	2005	Ducker CE et al.	Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis.
15657075	J. Cell. Sci.	2005	Stegmayer C et al.	Direct transport across the plasma membrane of mammalian cells of Leishmania HASPB as revealed by a CHO export mutant.
15637134	Clin. Chem.	2005	Fernández-Real JM et al.	Circulating adiponectin and plasma fatty acid profile.
14724220	J. Pharmacol. Exp. Ther.	2004	French KJ et al.	Cyclohexyl-octahydro-pyrrolo[1,2-a]pyrazine-based inhibitors of human N-myristoyltransferase-1.
14633729	Cancer Res.	2003	Shrivastav A et al.	Potent inhibitor of N-myristoylation: a novel molecular target for cancer.
11994481	J. Immunol.	2002	D'Hauteville H et al.	Two msbB genes encoding maximal acylation of lipid A are required for invasive Shigella flexneri to mediate inflammatory rupture and destruction of the intestinal epithelium.
11284718	Biochem. J.	2001	Guzzi F et al.	Thioacylation is required for targeting G-protein subunit G(o1alpha) to detergent-insoluble caveolin-containing membrane domains.
28137759	J. Cell. Sci.	2017	Demetriadou A et al.	Mouse Stbd1 is N-myristoylated and affects ER-mitochondria association and mitochondrial morphology.
27237364	Cell Host Microbe	2016	Trindade S et al.	Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice.
26621918	J. Lipid Res.	2016	Soupene E et al.	Association of NMT2 with the acyl-CoA carrier ACBD6 protects the N-myristoyltransferase reaction from palmitoyl-CoA.
26584780	Chem. Biol.	2015	Charlton TM et al.	Quantitative Lipoproteomics in Clostridium difficile Reveals a Role for Lipoproteins in Sporulation.
26423150	J. Immunol.	2015	Rampoldi F et al.	Immunosuppression and Aberrant T Cell Development in the Absence of N-Myristoylation.
26278174	Structure	2015	Zhang P et al.	An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes.
25833975	Am. J. Clin. Nutr.	2015	Drehmer M et al.	Associations of dairy intake with glycemia and insulinemia, independent of obesity, in Brazilian adults: the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
25773595	Mol. Cell	2015	Burnaevskiy N et al.	Myristoylome profiling reveals a concerted mechanism of ARF GTPase deacylation by the bacterial protease IpaJ.
24680960	Int J Pharm	2014	Pettit MW et al.	Construction and physiochemical characterisation of a multi-composite, potential oral vaccine delivery system (VDS).