lysophosphatidic acid

lysophosphatidic acid is a lipid of Glycerophospholipids (GP) class. Lysophosphatidic acid is associated with abnormalities such as Atherosclerosis, Alzheimer's Disease, Asthma, Diabetes Mellitus, Non-Insulin-Dependent and Septicemia. The involved functions are known as Inflammation, Chemotaxis, Binding (Molecular Function), Polymerization and Inflammatory Response. Lysophosphatidic acid often locates in Cytoskeleton, Microfilaments, actin cytoskeleton, Extracellular and Structure of germinal center of lymph node. The associated genes with lysophosphatidic acid are TNF gene, MAPK3 gene, RHOA gene, CDC42 gene and ADRBK1 gene. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Lysophosphatidylcholines, Lysophospholipids and Phosphatidic Acid. The related experimental models are Knock-out, Transgenic Model, Rodent Model and Disease model.

References related to functions published in Others

PMID	Journal	Published Date	Author	Title
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27641493	Neuron	2016	Cheng J et al.	Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling.
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27305954	Am. J. Clin. Nutr.	2016	Del Bas JM et al.	Impairment of lysophospholipid metabolism in obesity: altered plasma profile and desensitization to the modulatory properties of n-3 polyunsaturated fatty acids in a randomized controlled trial.
27161483	Cell Chem Biol	2016	Hövelmann F et al.	Optotaxis: Caged Lysophosphatidic Acid Enables Optical Control of a Chemotactic Gradient.
27030671	Mol. Biol. Cell	2016	Bartolini F et al.	An mDia1-INF2 formin activation cascade facilitated by IQGAP1 regulates stable microtubules in migrating cells.
27013613	Arterioscler. Thromb. Vasc. Biol.	2016	Ren B et al.	LPA/PKD-1-FoxO1 Signaling Axis Mediates Endothelial Cell CD36 Transcriptional Repression and Proangiogenic and Proarteriogenic Reprogramming.
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26671989	EMBO Mol Med	2016	Vogt J et al.	Molecular cause and functional impact of altered synaptic lipid signaling due to a prg-1 gene SNP.
26597701	Biochim. Biophys. Acta	2016	Nan L et al.	Cross-talk between lysophosphatidic acid receptor 1 and tropomyosin receptor kinase A promotes lung epithelial cell migration.
26476080	Neoplasia	2015	Mukherjee A et al.	Lysophosphatidic Acid Up-Regulates Hexokinase II and Glycolysis to Promote Proliferation of Ovarian Cancer Cells.
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26148725	J. Endocrinol.	2015	Kaneko I et al.	FGF23 gene regulation by 1,25-dihydroxyvitamin D: opposing effects in adipocytes and osteocytes.
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26079546	Exp. Mol. Pathol.	2015	Ayasolla KR et al.	Tubular cell phenotype in HIV-associated nephropathy: role of phospholipid lysophosphatidic acid.
26041536	J. Immunol.	2015	Causton B et al.	CARMA3 Is Critical for the Initiation of Allergic Airway Inflammation.
25934709	Mol. Cancer Ther.	2015	Xia Y et al.	Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both In Vitro and In Vivo.
25855080	Am. J. Physiol., Cell Physiol.	2015	No YR et al.	Regulation of NHE3 by lysophosphatidic acid is mediated by phosphorylation of NHE3 by RSK2.
25852197	Development	2015	Sheng X et al.	Lysophosphatidic acid signalling in development.
25695267	Neuron	2015	Yung YC et al.	Lysophosphatidic Acid signaling in the nervous system.
25683913	Cell. Signal.	2015	Guo L et al.	Krüppel-like factor 5 incorporates into the β-catenin/TCF complex in response to LPA in colon cancer cells.
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25578862	Cell. Signal.	2015	Wallert MA et al.	RhoA Kinase (Rock) and p90 Ribosomal S6 Kinase (p90Rsk) phosphorylation of the sodium hydrogen exchanger (NHE1) is required for lysophosphatidic acid-induced transport, cytoskeletal organization and migration.
25555354	Prostaglandins Leukot. Essent. Fatty Acids	2015	Block RC et al.	The effects of aspirin on platelet function and lysophosphatidic acids depend on plasma concentrations of EPA and DHA.
25464168	Osteoarthr. Cartil.	2015	Wu L et al.	Lysophosphatidic acid mediates fibrosis in injured joints by regulating collagen type I biosynthesis.
25451317	Cancer Lett.	2015	Ward JD et al.	LPA-mediated migration of ovarian cancer cells involves translocalization of Gαi2 to invadopodia and association with Src and β-pix.
25425621	Arterioscler. Thromb. Vasc. Biol.	2015	Kurano M et al.	Possible involvement of minor lysophospholipids in the increase in plasma lysophosphatidic acid in acute coronary syndrome.
25344254	J. Cell. Sci.	2014	Argenzio E et al.	CLIC4 regulates cell adhesion and β1 integrin trafficking.
25277122	Blood	2014	Leblanc R et al.	Interaction of platelet-derived autotaxin with tumor integrin αVβ3 controls metastasis of breast cancer cells to bone.
25190756	Blood	2014	Hsieh WC et al.	Inability to resolve specific infection generates innate immunodeficiency syndrome in Xiap-/- mice.
24750398	HPB (Oxford)	2014	Simo KA et al.	Altered lysophosphatidic acid (LPA) receptor expression during hepatic regeneration in a mouse model of partial hepatectomy.
24657741	Free Radic. Biol. Med.	2014	Klomsiri C et al.	Endosomal H2O2 production leads to localized cysteine sulfenic acid formation on proteins during lysophosphatidic acid-mediated cell signaling.
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24455753	Cancer Immunol Res	2013	Oda SK et al.	Lysophosphatidic acid inhibits CD8 T cell activation and control of tumor progression.
24445011	J. Formos. Med. Assoc.	2014	Wang CY et al.	Epigallocatechin-3-gallate inhibits lysophosphatidic acid-stimulated connective tissue growth factor via JNK and Smad3 suppression in human gingival fibroblasts.