stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
PMID | Journal | Published Date | Author | Title |
---|---|---|---|---|
2713491 | Blood | 1989 | Mitropoulos KA et al. | The activation of the contact phase of coagulation by physiologic surfaces in plasma: the effect of large negatively charged liposomal vesicles. |
9484999 | Arterioscler. Thromb. Vasc. Biol. | 1998 | Turpeinen AM et al. | Similar effects of diets rich in stearic acid or trans-fatty acids on platelet function and endothelial prostacyclin production in humans. |
9187629 | J. Nutr. | 1997 | Hassel CA et al. | Dietary stearic acid reduces plasma and hepatic cholesterol concentrations without increasing bile acid excretion in cholesterol-fed hamsters. |
9555866 | Arterioscler. Thromb. Vasc. Biol. | 1998 | Mennen L et al. | Factor VIIa response to a fat-rich meal does not depend on fatty acid composition: a randomized controlled trial. |
9732314 | J. Nutr. | 1998 | Enjalbert F et al. | Duodenal infusions of palmitic, stearic or oleic acids differently affect mammary gland metabolism of fatty acids in lactating dairy cows. |
11481404 | J. Nutr. | 2001 | Gupta SV and Khosla P | Palmitic and stearic acids similarly affect plasma lipoprotein metabolism in cynomolgus monkeys fed diets with adequate levels of linoleic acid. |
11689423 | EMBO J. | 2001 | Stehlin C et al. | X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation. |
11430415 | FEMS Microbiol. Lett. | 2001 | Radwan SS et al. | Effects of lipids on n-alkane attenuation in media supporting oil-utilizing microorganisms from the oily Arabian Gulf coasts. |
12177486 | Plant Physiol. | 2002 | Liu Q et al. | High-stearic and High-oleic cottonseed oils produced by hairpin RNA-mediated post-transcriptional gene silencing. |
11960778 | Am. J. Physiol. Gastrointest. Liver Physiol. | 2002 | Yao Y et al. | Regulation of triacylglycerol and phospholipid trafficking by fatty acids in newborn swine enterocytes. |
12368404 | J. Nutr. | 2002 | Cowles RL et al. | Dietary stearic acid alters gallbladder bile acid composition in hamsters fed cereal-based diets. |
12421851 | J. Nutr. | 2002 | Treadwell RM et al. | Glyceride stearic acid content and structure affect the energy available to growing rats. |
12226528 | Plant Physiol. | 2002 | Li C et al. | Resistance of cultivated tomato to cell content-feeding herbivores is regulated by the octadecanoid-signaling pathway. |
12663471 | Diabetes | 2003 | Eitel K et al. | Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells. |
12671095 | Plant Cell | 2003 | Bonaventure G et al. | Disruption of the FATB gene in Arabidopsis demonstrates an essential role of saturated fatty acids in plant growth. |
12606504 | Diabetes | 2003 | Weigert C et al. | Palmitate-induced activation of the hexosamine pathway in human myotubes: increased expression of glutamine:fructose-6-phosphate aminotransferase. |
10584037 | Am. J. Clin. Nutr. | 1999 | Connor WE | Harbingers of coronary heart disease: dietary saturated fatty acids and cholesterol. Is chocolate benign because of its stearic acid content? |
9761789 | Plant Cell | 1998 | Merlo AO et al. | Ribozymes targeted to stearoyl-ACP delta9 desaturase mRNA produce heritable increases of stearic acid in transgenic maize leaves. |
12031970 | Diabetes | 2002 | Dobbins RL et al. | The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats. |
14652360 | J. Nutr. | 2003 | Baer DJ et al. | Stearic acid absorption and its metabolizable energy value are minimally lower than those of other fatty acids in healthy men fed mixed diets. |
21653571 | J. Nutr. | 2011 | Lee YJ and Jenkins TC | Biohydrogenation of linolenic acid to stearic acid by the rumen microbial population yields multiple intermediate conjugated diene isomers. |
18996872 | Am. J. Clin. Nutr. | 2008 | Crowe FL et al. | Fatty acid composition of plasma phospholipids and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition. |
20385782 | Reproduction | 2010 | Bender K et al. | Metabolite concentrations in follicular fluid may explain differences in fertility between heifers and lactating cows. |
19783644 | Plant Physiol. | 2009 | Clemente TE and Cahoon EB | Soybean oil: genetic approaches for modification of functionality and total content. |
20100787 | Chem. Senses | 2010 | Bolton B and Halpern BP | Orthonasal and retronasal but not oral-cavity-only discrimination of vapor-phase fatty acids. |
21311036 | Biol. Reprod. | 2011 | Aardema H et al. | Oleic acid prevents detrimental effects of saturated fatty acids on bovine oocyte developmental competence. |
17556683 | Am. J. Clin. Nutr. | 2007 | Berry SE et al. | The solid fat content of stearic acid-rich fats determines their postprandial effects. |
17470478 | Gut | 2007 | Malhi H et al. | Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity. |
16317124 | J. Nutr. | 2005 | Thijssen MA et al. | Stearic, oleic, and linoleic acids have comparable effects on markers of thrombotic tendency in healthy human subjects. |
16990414 | Clin. Chem. | 2006 | Kazmierczak SC et al. | Electron spin resonance spectroscopy of serum albumin: a novel new test for cancer diagnosis and monitoring. |
17147764 | FEMS Microbiol. Lett. | 2006 | John Wallace R et al. | Clostridium proteoclasticum: A ruminal bacterium that forms stearic acid from linoleic acid. |
17056791 | J. Nutr. | 2006 | Rasmussen HE et al. | Reduction in cholesterol absorption is enhanced by stearate-enriched plant sterol esters in hamsters. |
16155261 | Am. J. Clin. Nutr. | 2005 | Thijssen MA and Mensink RP | Small differences in the effects of stearic acid, oleic acid, and linoleic acid on the serum lipoprotein profile of humans. |
16183866 | Reproduction | 2005 | Leroy JL et al. | Non-esterified fatty acids in follicular fluid of dairy cows and their effect on developmental capacity of bovine oocytes in vitro. |
18772370 | Proc. Natl. Acad. Sci. U.S.A. | 2008 | Terés S et al. | Oleic acid content is responsible for the reduction in blood pressure induced by olive oil. |
22556332 | Arterioscler. Thromb. Vasc. Biol. | 2012 | Anderson EK et al. | Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis. |
22459162 | Chem. Senses | 2012 | Wajid NA and Halpern BP | Oral cavity discrimination of vapor-phase long-chain 18-carbon fatty acids. |
23362303 | Circ Cardiovasc Genet | 2013 | Wu JH et al. | Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. |
24071507 | J. Nucl. Med. | 2013 | Mérian J et al. | Synthetic lipid nanoparticles targeting steroid organs. |
24242247 | Appl. Environ. Microbiol. | 2014 | Huang FC et al. | Expression and characterization of CYP52 genes involved in the biosynthesis of sophorolipid and alkane metabolism from Starmerella bombicola. |
19357638 | Mol. Syst. Biol. | 2009 | Atherton HJ et al. | Metabolomics of the interaction between PPAR-alpha and age in the PPAR-alpha-null mouse. |
19934003 | Diabetes | 2010 | Yeop Han C et al. | Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes: dissociation of adipocyte hypertrophy from inflammation. |
26739624 | Toxicol. Appl. Pharmacol. | 2016 | Michaut A et al. | A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen. |
23880231 | Cancer Prev Res (Phila) | 2013 | Subbaramaiah K et al. | Dietary polyphenols suppress elevated levels of proinflammatory mediators and aromatase in the mammary gland of obese mice. |
22679004 | Am. J. Physiol. Gastrointest. Liver Physiol. | 2012 | Bederman I et al. | Altered de novo lipogenesis contributes to low adipose stores in cystic fibrosis mice. |
22210486 | Int. J. Biol. Macromol. | 2012 | Singh AV and Nath LK | Evaluation of acetylated moth bean starch as a carrier for controlled drug delivery. |
22155069 | Anal. Biochem. | 2012 | Zhang J et al. | Synthesis of NaYF(4):Yb/Er/Gd up-conversion luminescent nanoparticles and luminescence resonance energy transfer-based protein detection. |
21995961 | Am. J. Physiol. Gastrointest. Liver Physiol. | 2012 | Kakisaka K et al. | Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis. |
21586336 | Biochim. Biophys. Acta | 2012 | Schreiber R et al. | Retinyl ester hydrolases and their roles in vitamin A homeostasis. |
21420932 | Biochim. Biophys. Acta | 2011 | Kordyukova LV et al. | Linker and/or transmembrane regions of influenza A/Group-1, A/Group-2, and type B virus hemagglutinins are packed differently within trimers. |
21378177 | Diabetes | 2011 | Nicholls HT et al. | Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue. |
21196123 | Trends Endocrinol. Metab. | 2011 | Santos GM et al. | Negative regulation by nuclear receptors: a plethora of mechanisms. |
20200316 | Diabetes | 2010 | Mas S et al. | Local non-esterified fatty acids correlate with inflammation in atheroma plaques of patients with type 2 diabetes. |
20006369 | Virology | 2010 | Kordyukova LV et al. | Site-specific attachment of palmitate or stearate to cytoplasmic versus transmembrane cysteines is a common feature of viral spike proteins. |
19945403 | Cell Metab. | 2009 | Hoppa MB et al. | Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules. |
19651814 | Diabetes | 2009 | Kantartzis K et al. | Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene. |
19581421 | Diabetes | 2009 | Bergman BC et al. | Intramuscular lipid metabolism in the insulin resistance of smoking. |
19478146 | Diabetes | 2009 | Peter A et al. | Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo. |
18718999 | Am. J. Physiol. Gastrointest. Liver Physiol. | 2008 | Labonté ED et al. | Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice. |
18633101 | Diabetes | 2008 | Reyna SM et al. | Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects. |
18054317 | Cell Metab. | 2007 | Miyazaki M et al. | Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis. |
16020521 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | 2005 | Tappia PS et al. | Phospholipid profile of developing heart of rats exposed to low-protein diet in pregnancy. |
15722436 | Biophys. J. | 2005 | Citadini AP et al. | EPR studies of chlorocatechol 1,2-dioxygenase: evidences of iron reduction during catalysis and of the binding of amphipatic molecules. |
15099193 | Biochem. J. | 2004 | Zhao H and Hardy RW | Long-chain saturated fatty acids induce annexin II translocation to detergent-resistant membranes. |
11415448 | Biochem. J. | 2001 | Zhang L et al. | Isolation and characterization of the human stearoyl-CoA desaturase gene promoter: requirement of a conserved CCAAT cis-element. |
27262269 | Int J Pharm | 2016 | Shur J et al. | From single excipients to dual excipient platforms in dry powder inhaler products. |
26711260 | Mol. Cell. Biol. | 2015 | Doignon F et al. | Requirement of Phosphoinositides Containing Stearic Acid To Control Cell Polarity. |
26701797 | J. Nutr. | 2016 | Fretts AM et al. | Associations of Plasma Phospholipid SFAs with Total and Cause-Specific Mortality in Older Adults Differ According to SFA Chain Length. |
25648816 | J. Dairy Sci. | 2015 | Aardema H et al. | Free fatty acid levels in fluid of dominant follicles at the preferred insemination time in dairy cows are not affected by early postpartum fatty acid stress. |
25527759 | Am. J. Clin. Nutr. | 2015 | Ma W et al. | Prospective association of fatty acids in the de novo lipogenesis pathway with risk of type 2 diabetes: the Cardiovascular Health Study. |
24970268 | J Am Heart Assoc | 2014 | Fretts AM et al. | Plasma phospholipid saturated fatty acids and incident atrial fibrillation: the Cardiovascular Health Study. |