Ganglioside GM2

Ganglioside GM2 is a lipid of Sphingolipids (SP) class. Ganglioside gm2 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Autoimmune Diseases, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating and Neuromuscular Diseases. The involved functions are known as Pressure- physical agent, Cytolysis, Inflammation, Complement-Dependent Cytotoxicity and conjugation. Ganglioside gm2 often locates in Membrane, Entire nervous system, Cell surface, Biopsy sample and Lipid Bilayers. The associated genes with Ganglioside GM2 are anti-IgM, Polypeptides, Transgenes, Alleles and Homologous Gene. The related lipids are Ganglioside GA2, QS 21, sulfate-3-glucuronyl paragloboside, Lipopolysaccharides and IV(4)-galactosyl-N-acetylganglioside GD1a. The related experimental models are Disease model.

References related to functions published in Others


PMIDJournalPublished DateAuthorTitle
17069778Carbohydr. Res.2007Larsson EA et al.Synthesis of reference standards to enable single cell metabolomic studies of tetramethylrhodamine-labeled ganglioside GM1.
16614007J. Neurol. Neurosurg. Psychiatry2006Kaida K et al.Anti-ganglioside complex antibodies in Miller Fisher syndrome.
15654767Biochem. J.2005Masson E et al.Glucosamine induces cell-cycle arrest and hypertrophy of mesangial cells: implication of gangliosides.
14871967Clin. Cancer Res.2004Krug LM et al.Vaccination of small cell lung cancer patients with polysialic acid or N-propionylated polysialic acid conjugated to keyhole limpet hemocyanin.
11358851Cancer Res.2001Yoshida S et al.Ganglioside G(D2) in small cell lung cancer cell lines: enhancement of cell proliferation and mediation of apoptosis.
11254608Infect. Immun.2001Ang CW et al.Guillain-Barré syndrome- and Miller Fisher syndrome-associated Campylobacter jejuni lipopolysaccharides induce anti-GM1 and anti-GQ1b Antibodies in rabbits.
9673245Infect. Immun.1998Prendergast MM et al.Lipopolysaccharides from Campylobacter jejuni O:41 strains associated with Guillain-Barré syndrome exhibit mimicry of GM1 ganglioside.
15850580J. Neurol. Sci.2005Usuki S et al.AIDP and CIDP having specific antibodies to the carbohydrate epitope (-NeuAcalpha2-8NeuAcalpha2-3Galbeta1-4Glc-) of gangliosides.
10751257Neurology2000Ang CW et al.Cross-reactive antibodies against GM2 and CMV-infected fibroblasts in Guillain-Barré syndrome.
27923633Brain Res.2017Trilck M et al.Diversity of glycosphingolipid GM2 and cholesterol accumulation in NPC1 patient-specific iPSC-derived neurons.
27491075Dis Model Mech2016Wolf H et al.A mouse model for fucosidosis recapitulates storage pathology and neurological features of the milder form of the human disease.
26175473J. Lipid Res.2015Anheuser S et al.Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity.
25873306ASN NeuroRockwell HE et al.AAV-mediated gene delivery in a feline model of Sandhoff disease corrects lysosomal storage in the central nervous system.
25717099Sci Transl Med2015Vite CH et al.Intracisternal cyclodextrin prevents cerebellar dysfunction and Purkinje cell death in feline Niemann-Pick type C1 disease.
25418946J Gene MedMcIntyre C et al.Correction of murine mucopolysaccharidosis type IIIA central nervous system pathology by intracerebroventricular lentiviral-mediated gene delivery.
24813327Clin Neurol Neurosurg2014Vachalová I et al.Anti-GM2, -GD1a and -GD1b positive purely isolated facial diplegia.
24769373Anal. Biochem.2014Fuller M et al.Liquid chromatography/electrospray ionisation-tandem mass spectrometry quantification of GM2 gangliosides in human peripheral cells and plasma.
23401234Synapse2013Rupp A et al.The effects of age and ganglioside composition on the rate of motor nerve terminal regeneration following antibody-mediated injury in mice.
21487393Mol. Ther.2011Matsuoka K et al.Therapeutic potential of intracerebroventricular replacement of modified human β-hexosaminidase B for GM2 gangliosidosis.
20187655ACS Chem. Biol.2010Ho CW et al.Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.
19706290Biochem. Biophys. Res. Commun.2009Tomioka R et al.Neuroblastoma GOTO cells are hypersensitive to disruption of lipid rafts.
19559406
19340910World J. Gastroenterol.2009Loly JP et al.Guillain-Barré syndrome following hepatitis E.
18368480Glycoconj. J.2008Komori T et al.Design and efficient synthesis of novel GM2 analogues with respect to the elucidation of the function of GM2 activator.
18241673Clin. Biochem.2008Gu J et al.Simultaneous quantification of GM1 and GM2 gangliosides by isotope dilution tandem mass spectrometry.
17915254J. Neurol. Sci.2008Nobile-Orazio E et al.How useful are anti-neural IgM antibodies in the diagnosis of chronic immune-mediated neuropathies?
17253773Biochemistry2007Martinez Z et al.GM1 specifically interacts with alpha-synuclein and inhibits fibrillation.
17198760J. Feline Med. Surg.2007Hasegawa D et al.Clinical and molecular analysis of GM2 gangliosidosis in two apparent littermate kittens of the Japanese domestic cat.
17196574Clin. Chim. Acta2007Tsuji D et al.Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies.
16962990Arch. Biochem. Biophys.2006Duan J et al.Ganglioside GM2 modulates the erythrocyte Ca2+-ATPase through its binding to the calmodulin-binding domain and its 'receptor'.
16707183J. Biotechnol.2006Thiesen PH et al.Glycolipids from a colloid chemical point of view.
16620986Mol. Immunol.2007López-Requena A et al.Gangliosides, Ab1 and Ab2 antibodies II. Light versus heavy chain: An idiotype-anti-idiotype case study.
16478472FEBS J.2006Wendeler M et al.The enzyme-binding region of human GM2-activator protein.
16200419Acta Neuropathol.2005Martin DR et al.Mutation of the GM2 activator protein in a feline model of GM2 gangliosidosis.
15953731Neurobiol. Dis.2005Arfi A et al.Bicistronic lentiviral vector corrects beta-hexosaminidase deficiency in transduced and cross-corrected human Sandhoff fibroblasts.
14722612J. Clin. Invest.2004Yamaguchi A et al.Possible role of autoantibodies in the pathophysiology of GM2 gangliosidoses.
12740812Chembiochem2003Antoine T et al.Large-scale in vivo synthesis of the carbohydrate moieties of gangliosides GM1 and GM2 by metabolically engineered Escherichia coli.
12705795Intern. Med.2003Mizutani K et al.Amyotrophic lateral sclerosis with IgM antibody against gangliosides GM2 and GD2.
12455030Int. J. Cancer2003Chen HH et al.Suppression of lung metastasis of mouse Lewis lung cancer P29 with transfection of the ganglioside GM2/GD2 synthase gene.
11828255Melanoma Res.2002Mehta RR et al.In vitro transformation of human congenital naevus to malignant melanoma.
11578853Brain Dev.2001Taniguchi M et al.Sites and temporal changes of gangliosides GM1/GM2 storage in the Niemann-Pick disease type C mouse brain.
11425192Glycoconj. J.2000Hedberg KM et al.Monoclonal anti-GD3 antibodies selectively inhibit the proliferation of human malignant glioma cells in vitro.
11230488J. Clin. Oncol.2001Kirkwood JM et al.High-dose interferon alfa-2b does not diminish antibody response to GM2 vaccination in patients with resected melanoma: results of the Multicenter Eastern Cooperative Oncology Group Phase II Trial E2696.
11064828Clin Rev Allergy Immunol2000Portoukalian JImmunogenicity of glycolipids.
10704706Lung Cancer2000Brezicka T et al.Reactivity of monoclonal antibodies with ganglioside antigens in human small cell lung cancer tissues.
10529115Microbiol. Immunol.1999Okada N et al.Human IgM monoclonal antibody to ganglioside GM2 and complement suppress virus propagation in ex vivo cultures of lymphocytes from HIV-1 infected patients.
10073593J. Am. Soc. Nephrol.1999Mundel TM et al.Ganglioside GM2-activator protein and vesicular transport in collecting duct intercalated cells.
9989797J. Invest. Dermatol.1999Takahashi T et al.IgM anti-ganglioside antibodies induced by melanoma cell vaccine correlate with survival of melanoma patients.
9972876Neurochem. Res.1999Usuki S et al.GM2 promotes ciliary neurotrophic factor-dependent rescue of immortalized motor neuron-like cell (NSC-34).
9797137Int. J. Cancer1998Hanibuchi M et al.Therapeutic efficacy of mouse-human chimeric anti-ganglioside GM2 monoclonal antibody against multiple organ micrometastases of human lung cancer in NK cell-depleted SCID mice.
9728970J. Neurol. Neurosurg. Psychiatry1998Tsukaguchi M et al.IgM anti-GM2 antibody in a patient with Guillain-Barré syndrome subsequent to cytomegalovirus hepatitis cross reacts with N-acetylgalactosaminyl GD1a.
9668352Ann. N. Y. Acad. Sci.1998Walkley SU et al.GM2 ganglioside as a regulator of pyramidal neuron dendritogenesis.
9572057Mol Med Today1998Chavany C and Jendoubi MBiology and potential strategies for the treatment of GM2 gangliosidoses.
9435988Clin. Chim. Acta1997Sandhoff K and Kolter TBiochemistry of glycosphingolipid degradation.
9153001Neurochem. Int.1997Nakamura K et al.Gangliosides of dogfish (Squalus acanthias) brain.
9130256Neurochem. Res.1997Maxzúd MK and Maccioni HJCompartmental organization of the synthesis of GM3, GD3, and GM2 in golgi membranes from neural retina cells.
8971173Cancer Res.1996Nishinaka Y et al.Development of a human monoclonal antibody to ganglioside G(M2) with potential for cancer treatment.
8757036Neurology1996De Gasperi R et al.Late-onset GM2 gangliosidosis: Ashkenazi Jewish family with an exon 5 mutation (Tyr180-->His) in the Hex A alpha-chain gene.
8544979Neuroscience1995Walkley SUPyramidal neurons with ectopic dendrites in storage diseases exhibit increased GM2 ganglioside immunoreactivity.
7659693Prenat. Diagn.1995Lemos M et al.Prenatal diagnosis of GM2-gangliosidosis B1 variant.
7590782Hybridoma1995Alfonso M et al.T cell-independent B cell response to self-monosialogangliosides: primary response monoclonal antibodies.
2479468Cancer Res.1989Vrionis FD et al.Five new epitope-defined monoclonal antibodies reactive with GM2 and human glioma and medulloblastoma cell lines.
6214395Eur. J. Biochem.1982Hasilik A et al.Lysosomal enzyme precursors in human fibroblasts. Activation of cathepsin D precursor in vitro and activity of beta-hexosaminidase A precursor towards ganglioside GM2.
7306091Biochem. Biophys. Res. Commun.1981Li SC et al.A new variant of type-AB GM2-gangliosidosis.
407331J. Neurochem.1977Bernheimer H et al.Sandhoff disease: ganglioside G(M2) and asialo-G(M2) accumulation in the cerebrospinal fluid.