Lysophosphatidylcholine

Lysophosphatidylcholine is a lipid of Glycerophospholipids (GP) class. Lysophosphatidylcholine is associated with abnormalities such as Ischemia, Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Fatty Liver and Atherosclerosis. The involved functions are known as Inflammation, antagonists, Signal Transduction, Signal Pathways and Saturated. Lysophosphatidylcholine often locates in Body tissue, Head, integral to membrane, Membrane and Extracellular. The associated genes with Lysophosphatidylcholine are RHOA gene, Homologous Gene, GPR4 gene, GPR68 gene and TRPV2 gene. The related lipids are Nonesterified Fatty Acids, lysophosphatidylethanolamine, Lysophosphatidylcholines, Phosphatidylserines and 25-hydroxycholesterol. The related experimental models are Knock-out and Disease model.

References related to genes published in Others

PMID	Journal	Published Date	Author	Title
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18922893	Cancer Res.	2008	Bartolomé RA et al.	Activated G(alpha)13 impairs cell invasiveness through p190RhoGAP-mediated inhibition of RhoA activity.
27480805	Biochim. Biophys. Acta	2016	Putta P et al.	Phosphatidic acid binding proteins display differential binding as a function of membrane curvature stress and chemical properties.
27178174	Biochim. Biophys. Acta	2016	Subbaiah PV et al.	Enhanced incorporation of dietary DHA into lymph phospholipids by altering its molecular carrier.
24532770	J. Bacteriol.	2014	Pride AC et al.	Characterization of the Vibrio cholerae VolA surface-exposed lipoprotein lysophospholipase.
23514731	Diabetes Care	2013	Lehmann R et al.	Circulating lysophosphatidylcholines are markers of a metabolically benign nonalcoholic fatty liver.
21130993	Atherosclerosis	2011	Riederer M et al.	Endothelial lipase (EL) and EL-generated lysophosphatidylcholines promote IL-8 expression in endothelial cells.
21123073	Bioorg. Med. Chem.	2011	Choi J et al.	An efficient synthesis of γ-hydroxy-α,β-unsaturated aldehydic esters of 2-lysophosphatidylcholine.
20799926	Biochem. J.	2010	Khan SY et al.	Lysophosphatidylcholines activate G2A inducing G(αi)₋₁-/G(αq/)₁₁- Ca²(+) flux, G(βγ)-Hck activation and clathrin/β-arrestin-1/GRK6 recruitment in PMNs.
19918071	Proc. Natl. Acad. Sci. U.S.A.	2009	Kirik A and Mudgett MB	SOBER1 phospholipase activity suppresses phosphatidic acid accumulation and plant immunity in response to bacterial effector AvrBsT.
19524551	Biochem. Biophys. Res. Commun.	2009	Burkholder TJ	Stretch-induced ERK2 phosphorylation requires PLA2 activity in skeletal myotubes.
17505011	Clin. Cancer Res.	2007	Maurer BJ et al.	Improved oral delivery of N-(4-hydroxyphenyl)retinamide with a novel LYM-X-SORB organized lipid complex.
16002999	Am. J. Physiol. Lung Cell Mol. Physiol.	2005	Mehta D	Lysophosphatidylcholine: an enigmatic lysolipid.
15280462	J. Virol.	2004	Stiasny K and Heinz FX	Effect of membrane curvature-modifying lipids on membrane fusion by tick-borne encephalitis virus.
12761247	J. Am. Soc. Nephrol.	2003	Galle J et al.	Oxidized LDL and its compound lysophosphatidylcholine potentiate AngII-induced vasoconstriction by stimulation of RhoA.
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12231511	EMBO Rep.	2002	Gardella S et al.	The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway.
11406493	Am. J. Physiol. Heart Circ. Physiol.	2001	Rikitake Y et al.	Regulation of tyrosine phosphorylation of PYK2 in vascular endothelial cells by lysophosphatidylcholine.
9734473	Circ. Res.	1998	Nishi E et al.	Lysophosphatidylcholine enhances cytokine-induced interferon gamma expression in human T lymphocytes.
9453311	Hypertension	1998	Yamakawa T et al.	Lysophosphatidylcholine stimulates MAP kinase activity in rat vascular smooth muscle cells.
9130444	Circ. Res.	1997	Nishi E et al.	Lysophosphatidylcholine increases expression of heparin-binding epidermal growth factor-like growth factor in human T lymphocytes.
2961438	Cancer Res.	1988	Shimura H et al.	Selective cytotoxicity of phospholipids and diacylglycerols to rat 3Y1 fibroblasts transformed by adenovirus type 12 or its E1A gene.