Zaragozic acid A

Zaragozic acid A is a lipid of Polyketides (PK) class. Zaragozic acid a is associated with abnormalities such as Hypercholesterolemia, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity, Atherosclerosis and Infection. The involved functions are known as Anabolism, Sterol Biosynthesis Pathway, isoprenoid biosynthetic process, Biochemical Pathway and Adverse effects. Zaragozic acid a often locates in Endoplasmic reticulum, membrane, viral nucleocapsid location, Cell surface, Hepatic and Membrane. The associated genes with Zaragozic acid A are DPM1 gene, PMM2 gene, STN gene, SLC6A7 gene and Amyloid beta-Protein Precursor. The related lipids are Sterols, Fatty Acids, Membrane Lipids, farnesoic acid and Unilamellar Vesicles. The related experimental models are Mouse Model.

References related to genes published in Others


PMIDJournalPublished DateAuthorTitle
9730906Mol. Pharmacol.1998Kocarek TA et al.Regulation of rat hepatic cytochrome P450 expression by sterol biosynthesis inhibition: inhibitors of squalene synthase are potent inducers of CYP2B expression in primary cultured rat hepatocytes and rat liver.
12391282Mol. Pharmacol.2002Kocarek TA and Mercer-Haines NASqualestatin 1-inducible expression of rat CYP2B: evidence that an endogenous isoprenoid is an activator of the constitutive androstane receptor.
12506040Blood2003Li HY et al.Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responses.
10817720Antimicrob. Agents Chemother.2000Kaneshiro ES et al.Inhibitors of sterol biosynthesis and amphotericin B reduce the viability of pneumocystis carinii f. sp. carinii.
20103534J. Cell. Sci.2010Linetti A et al.Cholesterol reduction impairs exocytosis of synaptic vesicles.
22649242J. Neurosci.2012Fünfschilling U et al.Critical time window of neuronal cholesterol synthesis during neurite outgrowth.