Tylosin

Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.

References related to genes published in Others

PMID	Journal	Published Date	Author	Title
11682559	J. Clin. Microbiol.	2001	Boerlin P et al.	Antimicrobial growth promoter ban and resistance to macrolides and vancomycin in enterococci from pigs.
12417742	Proc. Natl. Acad. Sci. U.S.A.	2002	Liu M and Douthwaite S	Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy.
12644222	FEMS Microbiol. Lett.	2003	Onan LJ and LaPara TM	Tylosin-resistant bacteria cultivated from agricultural soil.
12514124	EMBO J.	2003	Lebars I et al.	Structure of 23S rRNA hairpin 35 and its interaction with the tylosin-resistance methyltransferase RlmAII.
10802191	FEMS Microbiol. Lett.	2000	Fouces R et al.	Conjugation and transformation of Streptomyces species by tylosin resistance.
18079110	J. Biol. Chem.	2008	Petropoulos AD et al.	Stepwise binding of tylosin and erythromycin to Escherichia coli ribosomes, characterized by kinetic and footprinting analysis.
16873579	Mol. Pharmacol.	2006	Karahalios P et al.	On the mechanism of action of 9-O-arylalkyloxime derivatives of 6-O-mycaminosyltylonolide, a new class of 16-membered macrolide antibiotics.
17085767	J. Antimicrob. Chemother.	2007	Lüthje P and Schwarz S	Molecular analysis of constitutively expressed erm(C) genes selected in vitro in the presence of the non-inducers pirlimycin, spiramycin and tylosin.
22955886	Proc. Natl. Acad. Sci. U.S.A.	2012	Kim HB et al.	Microbial shifts in the swine distal gut in response to the treatment with antimicrobial growth promoter, tylosin.
23397987	FEMS Microbiol. Ecol.	2013	Holman DB and Chénier MR	Impact of subtherapeutic administration of tylosin and chlortetracycline on antimicrobial resistance in farrow-to-finish swine.
23928021	J. Antimicrob. Chemother.	2014	Buß M et al.	Quality control ranges for tylosin 30 μg and 15 μg discs applicable to Staphylococcus aureus ATCC(R) 25923.