erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
PMID | Journal | Published Date | Author | Title |
---|---|---|---|---|
20231358 | Mol. Cell. Biol. | 2010 | Im E et al. | Phospholipase Cgamma activation drives increased production of autotaxin in endothelial cells and lysophosphatidic acid-dependent regression. |
17314270 | Mol. Cancer Res. | 2007 | Do TV et al. | Lysophosphatidic acid down-regulates stress fibers and up-regulates pro-matrix metalloproteinase-2 activation in ovarian cancer cells. |
15710620 | J. Biol. Chem. | 2005 | Simon MF et al. | Lysophosphatidic acid inhibits adipocyte differentiation via lysophosphatidic acid 1 receptor-dependent down-regulation of peroxisome proliferator-activated receptor gamma2. |
9422686 | Science | 1998 | Marsden AF et al. | Engineering broader specificity into an antibiotic-producing polyketide synthase. |
12044681 | FEMS Microbiol. Lett. | 2002 | Kim YH et al. | Purification and characterization of an erythromycin esterase from an erythromycin-resistant Pseudomonas sp. |
12235254 | J. Pharmacol. Exp. Ther. | 2002 | Milberg P et al. | Divergent proarrhythmic potential of macrolide antibiotics despite similar QT prolongation: fast phase 3 repolarization prevents early afterdepolarizations and torsade de pointes. |
12235267 | J. Pharmacol. Exp. Ther. | 2002 | Yasuda K et al. | Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. |
12606769 | Mol. Pharmacol. | 2003 | Dinos GP et al. | Erythromycin, roxithromycin, and clarithromycin: use of slow-binding kinetics to compare their in vitro interaction with a bacterial ribosomal complex active in peptide bond formation. |
20876130 | Proc. Natl. Acad. Sci. U.S.A. | 2010 | Bulkley D et al. | Revisiting the structures of several antibiotics bound to the bacterial ribosome. |
20418422 | Appl. Environ. Microbiol. | 2010 | Useglio M et al. | TDP-L-megosamine biosynthesis pathway elucidation and megalomicin a production in Escherichia coli. |
18205815 | FEMS Microbiol. Ecol. | 2008 | Elevi Bardavid R and Oren A | Sensitivity of Haloquadratum and Salinibacter to antibiotics and other inhibitors: implications for the assessment of the contribution of Archaea and Bacteria to heterotrophic activities in hypersaline environments. |
15870344 | Appl. Environ. Microbiol. | 2005 | PeirĂș S et al. | Production of the potent antibacterial polyketide erythromycin C in Escherichia coli. |
16514147 | Microbiology (Reading, Engl.) | 2006 | RodrĂguez E et al. | In vivo characterization of the dTDP-D-desosamine pathway of the megalomicin gene cluster from Micromonospora megalomicea. |
17110371 | J. Biol. Chem. | 2007 | Sidhu AB et al. | In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin. |
16575736 | Clin. Infect. Dis. | 2006 | Gagliotti C et al. | Macrolide prescriptions and erythromycin resistance of Streptococcus pyogenes. |
23542952 | Am. J. Physiol. Lung Cell Mol. Physiol. | 2013 | Tarran R et al. | Nonantibiotic macrolides prevent human neutrophil elastase-induced mucus stasis and airway surface liquid volume depletion. |
24014644 | Toxicol. Sci. | 2013 | Pedersen JM et al. | Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). |