MAYTANSINE

MAYTANSINE is a lipid of Polyketides (PK) class. Maytansine is associated with abnormalities such as Myelosuppression and BOSLEY-SALIH-ALORAINY SYNDROME. The involved functions are known as Mutation, Agent, Polymerization, Cell Cycle Arrest and Drug Kinetics. Maytansine often locates in Cytoplasm, Hepatic, Lysosomes, Cell surface and Microtubules. The associated genes with MAYTANSINE are ABCB1 gene, HM13 gene, CNN1 gene, CYP2C8 gene and CYP2D6 gene. The related lipids are Valerates. The related experimental models are Xenograft Model.

References related to genes published in Others


PMIDJournalPublished DateAuthorTitle
20937595Mol. Cancer Ther.2010Oroudjev E et al.Maytansinoid-antibody conjugates induce mitotic arrest by suppressing microtubule dynamic instability.
27889646Neoplasia2016Ponte JF et al.Mirvetuximab Soravtansine (IMGN853), a Folate Receptor Alpha-Targeting Antibody-Drug Conjugate, Potentiates the Activity of Standard of Care Therapeutics in Ovarian Cancer Models.
25114240Proc. Natl. Acad. Sci. U.S.A.2014Prota AE et al.A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs.