apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

References related to genes published in Others

PMID	Journal	Published Date	Author	Title
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12485947	Drug Metab. Dispos.	2003	Leslie EM et al.	Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1).
12893842	J. Pharmacol. Exp. Ther.	2003	Hu M et al.	Metabolism of flavonoids via enteric recycling: mechanistic studies of disposition of apigenin in the Caco-2 cell culture model.
12842827	Am. J. Physiol. Gastrointest. Liver Physiol.	2003	Farah M et al.	5,6-Dichloro-ribifuranosylbenzimidazole- and apigenin-induced sensitization of colon cancer cells to TNF-alpha-mediated apoptosis.
11078699	Am. J. Physiol., Cell Physiol.	2000	Illek B et al.	Structural determinants for activation and block of CFTR-mediated chloride currents by apigenin.
14563892	J. Antimicrob. Chemother.	2003	Koo H et al.	Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesol.
15131058	Clin. Cancer Res.	2004	Shukla S and Gupta S	Suppression of constitutive and tumor necrosis factor alpha-induced nuclear factor (NF)-kappaB activation and induction of apoptosis by apigenin in human prostate carcinoma PC-3 cells: correlation with down-regulation of NF-kappaB-responsive genes.
14709621	Drug Metab. Dispos.	2004	Gradolatto A et al.	Metabolism of apigenin by rat liver phase I and phase ii enzymes and by isolated perfused rat liver.
14608117	J. Nutr.	2003	Van Dross R et al.	The chemopreventive bioflavonoid apigenin modulates signal transduction pathways in keratinocyte and colon carcinoma cell lines.
21505181	Cancer Prev Res (Phila)	2011	Mafuvadze B et al.	Apigenin prevents development of medroxyprogesterone acetate-accelerated 7,12-dimethylbenz(a)anthracene-induced mammary tumors in Sprague-Dawley rats.
18952844	Proc. Natl. Acad. Sci. U.S.A.	2008	Cai X and Liu X	Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage.
19666609	Proc. Natl. Acad. Sci. U.S.A.	2009	Rebholz H et al.	CK2 negatively regulates Galphas signaling.
19398503	Drug Metab. Dispos.	2009	Maeno K et al.	Molecular basis for reduced estrone sulfate transport and altered modulator sensitivity of transmembrane helix (TM) 6 and TM17 mutants of multidrug resistance protein 1 (ABCC1).
19403720	J. Nutr.	2009	Hanske L et al.	The bioavailability of apigenin-7-glucoside is influenced by human intestinal microbiota in rats.
21346142	Mol. Pharmacol.	2011	Zhou Y et al.	Mucin 1 C-terminal subunit oncoprotein is a target for small-molecule inhibitors.
17982104	J. Immunol.	2007	Nicholas C et al.	Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.
17289898	Clin. Cancer Res.	2007	Kim JS et al.	Protein kinase CK2alpha as an unfavorable prognostic marker and novel therapeutic target in acute myeloid leukemia.
17369433	Plant Physiol.	2007	Marinova K et al.	Flavonoid biosynthesis in barley primary leaves requires the presence of the vacuole and controls the activity of vacuolar flavonoid transport.
17638904	Cancer Res.	2007	Shukla S et al.	Blockade of beta-catenin signaling by plant flavonoid apigenin suppresses prostate carcinogenesis in TRAMP mice.
18178667	Mol. Pharmacol.	2008	Puppala D et al.	Development of an aryl hydrocarbon receptor antagonist using the proteolysis-targeting chimeric molecules approach: a potential tool for chemoprevention.
18413777	Cancer Res.	2008	Abu-Yousif AO et al.	Enhancement of UVB-induced apoptosis by apigenin in human keratinocytes and organotypic keratinocyte cultures.
15746177	FASEB J.	2005	Fang J et al.	Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways.
16357145	Cancer Res.	2005	Eddy SF et al.	Inducible IkappaB kinase/IkappaB kinase epsilon expression is induced by CK2 and promotes aberrant nuclear factor-kappaB activation in breast cancer cells.
16246933	J. Dent. Res.	2005	Koo H et al.	Apigenin and tt-farnesol with fluoride effects on S. mutans biofilms and dental caries.
15897466	Proc. Natl. Acad. Sci. U.S.A.	2005	Yamada M et al.	Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis.
15947208	Mol. Pharmacol.	2005	Liu LZ et al.	Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancer.
17074806	Mol. Cell. Biol.	2007	Tong X et al.	Apigenin prevents UVB-induced cyclooxygenase 2 expression: coupled mRNA stabilization and translational inhibition.
16782805	Mol. Pharmacol.	2006	Yoon MS et al.	Apigenin inhibits immunostimulatory function of dendritic cells: Implication of immunotherapeutic adjuvant.
16581776	Mol. Cell. Biol.	2006	Li X et al.	NKX3.1 is regulated by protein kinase CK2 in prostate tumor cells.
22923679	Plant Physiol.	2012	Berim A et al.	A set of regioselective O-methyltransferases gives rise to the complex pattern of methoxylated flavones in sweet basil.
23697369	Proc. Natl. Acad. Sci. U.S.A.	2013	Arango D et al.	Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets.
23113475	FEMS Microbiol. Lett.	2013	Dong J et al.	Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.
20534735	Plant Physiol.	2010	Brechenmacher L et al.	Soybean metabolites regulated in root hairs in response to the symbiotic bacterium Bradyrhizobium japonicum.
21467581	Plant Cell	2011	Zhao J et al.	MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.
19074529	Drug Metab. Dispos.	2009	Si D et al.	Mechanism of CYP2C9 inhibition by flavones and flavonols.
18703119	Neuroscience	2008	Song J et al.	DNA topoisomerase I inhibitors ameliorate seizure-like behaviors and paralysis in a Drosophila model of epilepsy.
25058688	Chem. Biol. Interact.	2014	Isoda H et al.	Analysis of the erythroid differentiation effect of flavonoid apigenin on K562 human chronic leukemia cells.
23782265	Biochem. J.	2013	Wiejak J et al.	Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells.
20576813	Blood	2010	Shehata M et al.	Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia.
18793716	Cell. Signal.	2008	Harris SM et al.	The interferon-gamma-mediated inhibition of lipoprotein lipase gene transcription in macrophages involves casein kinase 2- and phosphoinositide-3-kinase-mediated regulation of transcription factors Sp1 and Sp3.
16954429	Endocr. Relat. Cancer	2006	Singh RP and Agarwal R	Mechanisms of action of novel agents for prostate cancer chemoprevention.
16400007	Am. J. Pathol.	2006	Sawatzky DA et al.	The involvement of the apoptosis-modulating proteins ERK 1/2, Bcl-xL and Bax in the resolution of acute inflammation in vivo.
12975498	J. Pharmacol. Exp. Ther.	2003	Wang H et al.	Up-regulation of endothelial nitric-oxide synthase by endothelium-derived hyperpolarizing factor involves mitogen-activated protein kinase and protein kinase C signaling pathways.
12788225	Biochim. Biophys. Acta	2003	Kim K et al.	Galectin-3 expression in macrophages is signaled by Ras/MAP kinase pathway and up-regulated by modified lipoproteins.
26526895	Int. J. Antimicrob. Agents	2015	Morimoto Y et al.	Apigenin as an anti-quinolone-resistance antibiotic.
26500281	Biosci. Rep.	2015	Seo HS et al.	Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells.
26269546	Plant Physiol.	2015	Falcone Ferreyra ML et al.	The Identification of Maize and Arabidopsis Type I FLAVONE SYNTHASEs Links Flavones with Hormones and Biotic Interactions.
25965143	Redox Biol	2015	Banerjee K and Mandal M	Oxidative stress triggered by naturally occurring flavone apigenin results in senescence and chemotherapeutic effect in human colorectal cancer cells.
24837156	Bioorg. Med. Chem.	2014	Chen H et al.	Design, synthesis, and characterization of novel apigenin analogues that suppress pancreatic stellate cell proliferation in vitro and associated pancreatic fibrosis in vivo.