FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

References related to genes published in Others

PMID	Journal	Published Date	Author	Title
16987811	J. Biol. Chem.	2006	Lotito SB and Frei B	Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells. Structure-function relationships and activity after first pass metabolism.
21467581	Plant Cell	2011	Zhao J et al.	MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.
21586682	Plant Cell	2011	Martin C et al.	How can research on plants contribute to promoting human health?
20357139	Plant Physiol.	2010	Han Y et al.	Ectopic expression of apple F3'H genes contributes to anthocyanin accumulation in the Arabidopsis tt7 mutant grown under nitrogen stress.
20008451	Mol Plant	2010	Morant M et al.	Metabolomic, transcriptional, hormonal, and signaling cross-talk in superroot2.
22587837	Biochim. Biophys. Acta	2012	Hirohata M et al.	Anti-amyloidogenic effects of soybean isoflavones in vitro: Fluorescence spectroscopy demonstrating direct binding to Aβ monomers, oligomers and fibrils.
23782265	Biochem. J.	2013	Wiejak J et al.	Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells.
25498791	J. Allergy Clin. Immunol.	2015	Weng Z et al.	The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells.
21075839	J. Pharmacol. Exp. Ther.	2011	Wootten D et al.	Modulation of the glucagon-like peptide-1 receptor signaling by naturally occurring and synthetic flavonoids.
19324938	Diabetes	2009	Wang Y et al.	Inactivation of GSK-3beta by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling.
18294953	Arch. Biochem. Biophys.	2008	Henry EC and Gasiewicz TA	Molecular determinants of species-specific agonist and antagonist activity of a substituted flavone towards the aryl hydrocarbon receptor.
18287248	Mol. Pharmacol.	2008	Takada Y et al.	Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase (MAPK), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells.
17418982	Cancer Detect. Prev.	2007	Ullmannova V and Popescu NC	Inhibition of cell proliferation, induction of apoptosis, reactivation of DLC1, and modulation of other gene expression by dietary flavone in breast cancer cell lines.
14645680	Mol. Pharmacol.	2003	Wenzel U et al.	Nitric oxide levels in human preneoplastic colonocytes determine their susceptibility toward antineoplastic agents.
14630924	J. Biol. Chem.	2004	Takada Y and Aggarwal BB	Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9.