Prostaglandin E2

Prostaglandin E2 is a lipid of Fatty Acyls (FA) class. Prostaglandin e2 is associated with abnormalities such as Renal glomerular disease, Arthritis, Degenerative polyarthritis, Pancreatitis and Rheumatoid Arthritis. The involved functions are known as enzyme pathway, Atherogenesis, Anabolism, inhibitors and Oxidants. Prostaglandin e2 often locates in Tissue membrane, Blood, Extracellular, Membrane and Protoplasm. The associated genes with Prostaglandin E2 are PTGS2 gene, TP53 gene, TNFRSF5 gene, FASTK Gene and TNF gene. The related lipids are Lipopolysaccharides, Steroids, monooxyethylene trimethylolpropane tristearate, Fatty Acids, Unsaturated and Promega. The related experimental models are Arthritis, Adjuvant-Induced, Xenograft Model, Experimental Autoimmune Encephalomyelitis, Cancer Model and Knock-out.

References related to genes published in Others


PMIDJournalPublished DateAuthorTitle
12893632Am. J. Physiol. Gastrointest. Liver Physiol.2003Harada N et al.Contribution of capsaicin-sensitive sensory neurons to stress-induced increases in gastric tissue levels of prostaglandins in rats.
19671757Mol. Cancer Ther.2009Koeberle A et al.Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1.
16699067J. Pharmacol. Exp. Ther.2006Hatazawa R et al.Roles of endogenous prostaglandins and cyclooxygenase isozymes in healing of indomethacin-induced small intestinal lesions in rats.
27664754Vascul. Pharmacol.2016Theiler A et al.The EP1/EP3 receptor agonist 17-pt-PGE2 acts as an EP4 receptor agonist on endothelial barrier function and in a model of LPS-induced pulmonary inflammation.
22859831J. Leukoc. Biol.2012Serra-Pages M et al.E-prostanoid 2 receptors dampen mast cell degranulation via cAMP/PKA-mediated suppression of IgE-dependent signaling.
21896757Proc. Natl. Acad. Sci. U.S.A.2011Clasadonte J et al.Prostaglandin E2 release from astrocytes triggers gonadotropin-releasing hormone (GnRH) neuron firing via EP2 receptor activation.
18981149J. Immunol.2008Sturm EM et al.Prostaglandin E2 inhibits eosinophil trafficking through E-prostanoid 2 receptors.
18583546J. Pharmacol. Exp. Ther.2008Yu L et al.E series of prostaglandin receptor 2-mediated activation of extracellular signal-regulated kinase/activator protein-1 signaling is required for the mitogenic action of prostaglandin E2 in esophageal squamous-cell carcinoma.
17557799Am. J. Physiol. Lung Cell Mol. Physiol.2007Thomas PE et al.PGE(2) inhibition of TGF-beta1-induced myofibroblast differentiation is Smad-independent but involves cell shape and adhesion-dependent signaling.
16971491Am. J. Physiol., Cell Physiol.2007Huber RD et al.Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain.
9730918Mol. Pharmacol.1998Kedzie KM et al.A single amino-acid substitution in the EP2 prostaglandin receptor confers responsiveness to prostacyclin analogs.
22802632Proc. Natl. Acad. Sci. U.S.A.2012Liu T et al.Prostaglandin E2 deficiency uncovers a dominant role for thromboxane A2 in house dust mite-induced allergic pulmonary inflammation.
16973753Proc. Natl. Acad. Sci. U.S.A.2006Wang M et al.Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis.
16027259Circulation2005Song Y et al.Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice.
15155179Am. J. Physiol. Gastrointest. Liver Physiol.2004Gookin JL et al.Nitric oxide synthase stimulates prostaglandin synthesis and barrier function in C. parvum-infected porcine ileum.
9291137Biochem. J.1997Karim S et al.Regulatory role of prostaglandin E2 in induction of cyclo-oxygenase-2 by a thromboxane A2 analogue (U46619) and basic fibroblast growth factor in porcine aortic smooth-muscle cells.
18339853Cancer Res.2008Accioly MT et al.Lipid bodies are reservoirs of cyclooxygenase-2 and sites of prostaglandin-E2 synthesis in colon cancer cells.
25595355Theriogenology2015Kowalewski MP et al.Formation of the early canine CL and the role of prostaglandin E2 (PGE2) in regulation of its function: an in vivo approach.
16467083Clin. Cancer Res.2006D'Orazi G et al.Homeodomain-interacting protein kinase-2 restrains cytosolic phospholipase A2-dependent prostaglandin E2 generation in human colorectal cancer cells.
12181161Am. J. Physiol. Gastrointest. Liver Physiol.2002Zhu Y et al.Ca2+- and PKC-dependent stimulation of PGE2 synthesis by deoxycholic acid in human colonic fibroblasts.
28571770Food Chem. Toxicol.2017Kim HG et al.Leptin induces CREB-dependent aromatase activation through COX-2 expression in breast cancer cells.
27697457Toxicology2016Su HH et al.Aryl hydrocarbon receptor-ligand axis mediates pulmonary fibroblast migration and differentiation through increased arachidonic acid metabolism.
25094029Toxicol. Appl. Pharmacol.2014Zheng H et al.Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion.
24365262Food Chem. Toxicol.2014Jayasooriya RG et al.Anti-inflammatory effects of β-hydroxyisovalerylshikonin in BV2 microglia are mediated through suppression of the PI3K/Akt/NF-kB pathway and activation of the Nrf2/HO-1 pathway.
23827175Mol. Cell. Endocrinol.2013Yu A et al.Resistin impairs SIRT1 function and induces senescence-associated phenotype in hepatocytes.
21878375Toxicol. Lett.2011Hollebeeck S et al.Dimethyl sulfoxide (DMSO) attenuates the inflammatory response in the in vitro intestinal Caco-2 cell model.
21803157Mol. Cell. Neurosci.2011Consonni A et al.Inhibition of lipopolysaccharide-induced microglia activation by calcitonin gene related peptide and adrenomedullin.
20678559Toxicol. Lett.2010Han EH et al.The role of cyclooxygenase-2-dependent signaling via cyclic AMP response element activation on aromatase up-regulation by o,p'-DDT in human breast cancer cells.
20335389Mol. Pharmacol.2010Ji R et al.EP1 prostanoid receptor coupling to G i/o up-regulates the expression of hypoxia-inducible factor-1 alpha through activation of a phosphoinositide-3 kinase signaling pathway.
20171164Biochem. Biophys. Res. Commun.2010Kihara T et al.Abeta-induced BACE-1 cleaves N-terminal sequence of mPGES-2.
19954759Toxicology2010Takaoka K et al.Opposite effects of two thiazolidinediones, ciglitazone and troglitazone, on proteinase-activated receptor-1-triggered prostaglandin E(2) release.
19808956Cancer Res.2009Lee KM et al.Tpl2 is a key mediator of arsenite-induced signal transduction.
19393675Toxicol. Appl. Pharmacol.2009Kakita H et al.Diclofenac enhances proinflammatory cytokine-induced nitric oxide production through NF-kappaB signaling in cultured astrocytes.
19273625J. Exp. Med.2009Boniface K et al.Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.
18952292Mol. Immunol.2009Cloosen S et al.Surface Mucin-1 does not play a role in dendritic cell migration.
17242161J. Exp. Med.2007Gross S et al.Vascular wall-produced prostaglandin E2 exacerbates arterial thrombosis and atherothrombosis through platelet EP3 receptors.
16784723Biochem. Pharmacol.2006Kanda N and Watanabe SSuppressive effects of antimycotics on tumor necrosis factor-alpha-induced CCL27, CCL2, and CCL5 production in human keratinocytes.
16777358Toxicol. Lett.2006Seok SM et al.COX-2 is associated with cadmium-induced ICAM-1 expression in cerebrovascular endothelial cells.
16754782Mol. Pharmacol.2006Wu BN et al.Inhibition of proinflammatory tumor necrosis factor-{alpha}-induced inducible nitric-oxide synthase by xanthine-based 7-[2-[4-(2-chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine (KMUP-1) and 7-[2-[4-(4-nitrobenzene)piperazinyl]ethyl]-1, 3-dimethylxanthine (KMUP-3) in rat trachea: The involvement of soluble guanylate cyclase and protein kinase G.
16492401Osteoarthr. Cartil.2006López-Armada MJ et al.Cytokines, tumor necrosis factor-alpha and interleukin-1beta, differentially regulate apoptosis in osteoarthritis cultured human chondrocytes.
16489006Cancer Res.2006Hiraga T et al.Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer.
16293616J. Biol. Chem.2006Holla VR et al.Prostaglandin E2 regulates the nuclear receptor NR4A2 in colorectal cancer.
15816358Exp. Toxicol. Pathol.2005Rincón-Sánchez AR et al.PGE2 alleviates kidney and liver damage, decreases plasma renin activity and acute phase response in cirrhotic rats with acute liver damage.
15753380Cancer Res.2005Wang D et al.Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade.
15491851Nitric Oxide2004Jones CP et al.Prostaglandin E2 and dexamethasone regulate eosinophil differentiation and survival through a nitric oxide- and CD95-dependent pathway.
12370375J. Immunol.2002Madden KB et al.Role of STAT6 and mast cells in IL-4- and IL-13-induced alterations in murine intestinal epithelial cell function.
12164941J. Invest. Dermatol.2002Kanda N and Watanabe SKetoconazole suppresses prostaglandin E(2)-induced cyclooxygenase-2 expression in human epidermoid carcinoma A-431 cells.
12110441Bone2002Ahlen J et al.Characterization of the bone-resorptive effect of interleukin-11 in cultured mouse calvarial bones.
11369638Blood2001Kaliński P et al.Prostaglandin E(2) is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer.
11164953Regul. Pept.2001Lindström E and Håkanson RNeurohormonal regulation of secretion from isolated rat stomach ECL cells: a critical reappraisal.
11094054J. Biol. Chem.2001Ribardo DA et al.Prostaglandin levels in stimulated macrophages are controlled by phospholipase A2-activating protein and by activation of phospholipase C and D.
10357836J. Lipid Res.1999Mater MK et al.Arachidonic acid and PGE2 regulation of hepatic lipogenic gene expression.
9187264Mol. Pharmacol.1997Shayo C et al.Histamine modulates the expression of c-fos through cyclic AMP production via the H2 receptor in the human promonocytic cell line U937.
29046334EMBO J.2017Sabirov RZ et al.The organic anion transporter SLCO2A1 constitutes the core component of the Maxi-Cl channel.
28877931Mol. Pharmacol.2017Taylor EJA et al.Prostaglandin E2 Inhibits Histamine-Evoked Ca2+ Release in Human Aortic Smooth Muscle Cells through Hyperactive cAMP Signaling Junctions and Protein Kinase A.
28864467J. Pharmacol. Exp. Ther.2017Schippers M et al.Upregulation of Epac-1 in Hepatic Stellate Cells by Prostaglandin E2 in Liver Fibrosis Is Associated with Reduced Fibrogenesis.
28837884Mol. Immunol.2017Che D et al.Macrophages induce EMT to promote invasion of lung cancer cells through the IL-6-mediated COX-2/PGE2/β-catenin signalling pathway.
28780305Exp. Cell Res.2017Liu Y et al.Activated hepatic stellate cells directly induce pathogenic Th17 cells in chronic hepatitis B virus infection.
28602931Eur J Med Genet2017Ma W et al.Pachydermoperiostosis of the complete type: A novel missense mutation c.101T > C in the SLCO2A1 gene.
28288820Biochem. Pharmacol.2017Yang CM et al.Resveratrol inhibits BK-induced COX-2 transcription by suppressing acetylation of AP-1 and NF-κB in human rheumatoid arthritis synovial fibroblasts.
28283650
28235500J Clin Anesth2017Luan YH et al.Action of β-endorphin and nonsteroidal anti-inflammatory drugs, and the possible effects of nonsteroidal anti-inflammatory drugs on β-endorphin.
28202625Cancer Discov2017Loo TM et al.Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity.
28193829J. Immunol.2017Horvatinovich JM et al.Soluble CD83 Inhibits T Cell Activation by Binding to the TLR4/MD-2 Complex on CD14+ Monocytes.
28137629Mol. Biochem. Parasitol.2017Kutyrev IA et al.Prostaglandins E2 and D2-regulators of host immunity in the model parasite Diphyllobothrium dendriticum: An immunocytochemical and biochemical study.
28062696J. Immunol.2017Hooper KM et al.Prostaglandin E2 Inhibition of IL-27 Production in Murine Dendritic Cells: A Novel Mechanism That Involves IRF1.
27998743Int. Immunopharmacol.2017Weng L et al.Ampelopsin attenuates lipopolysaccharide-induced inflammatory response through the inhibition of the NF-κB and JAK2/STAT3 signaling pathways in microglia.
27864128Gastroenterology2017Kim HB et al.Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice.
27827823Blood2017Kawano Y et al.G-CSF-induced sympathetic tone provokes fever and primes antimobilizing functions of neutrophils via PGE2.
27806992FASEB J.2017Laan LC et al.The whipworm (Trichuris suis) secretes prostaglandin E2 to suppress proinflammatory properties in human dendritic cells.
27554763Cancer Prev Res (Phila)2016Boutaud O et al.Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis.
27503928Cancer Res.2016Alba-Castellón L et al.Snail1-Dependent Activation of Cancer-Associated Fibroblast Controls Epithelial Tumor Cell Invasion and Metastasis.
27797821EMBO J.2017Miyoshi H et al.Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium.
27624482Reproduction2016Liu PP et al.Activin A upregulates PTGS2 expression and increases PGE2 production in human granulosa-lutein cells.
27771306Exp. Cell Res.2016Fu Y et al.Overexpression of HMGB1 A-box reduced IL-1β-induced MMP expression and the production of inflammatory mediators in human chondrocytes.
27515217Med. Hypotheses2016Chen Y et al.Prostaglandin E2 and Connexin 43 crosstalk in the osteogenesis induced by extracorporeal shockwave.
27499447Prostaglandins Leukot. Essent. Fatty Acids2016Lutter AH et al.Biphasic influence of PGE2 on the resorption activity of osteoclast-like cells derived from human peripheral blood monocytes and mouse RAW264.7 cells.
27292189Cell Stem Cell2016Schewe M et al.Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer.
27262506Exp. Cell Res.2016Hassan L et al.Resistance to ursolic acid-induced apoptosis through involvement of melanogenesis and COX-2/PGE2 pathways in human M4Beu melanoma cancer cells.
27260940Vascul. Pharmacol.2016Kraemer MP et al.Regulation of arterial reactivity by concurrent signaling through the E-prostanoid receptor 3 and angiotensin receptor 1.
27177970Arch. Biochem. Biophys.2016Akasaka H and Ruan KHIdentification of the two-phase mechanism of arachidonic acid regulating inflammatory prostaglandin E2 biosynthesis by targeting COX-2 and mPGES-1.
27131287Environ. Toxicol. Pharmacol.2016Dilshara MG et al.Morin downregulates nitric oxide and prostaglandin E2 production in LPS-stimulated BV2 microglial cells by suppressing NF-κB activity and activating HO-1 induction.
27118338Pharmacol. Ther.2016Conejo-Garcia JR et al.State-of-the-art of regulatory dendritic cells in cancer.
27105159Atherosclerosis2016Santilli F et al.The Coxib case: Are EP receptors really guilty?
27001836Proc. Natl. Acad. Sci. U.S.A.2016Hangai S et al.PGE2 induced in and released by dying cells functions as an inhibitory DAMP.
26989254Science2016Duffin R et al.Prostaglandin E₂ constrains systemic inflammation through an innate lymphoid cell-IL-22 axis.
26928462Cancer Immunol Res2016Basingab FS et al.IFNγ-Dependent Interactions between ICAM-1 and LFA-1 Counteract Prostaglandin E2-Mediated Inhibition of Antitumor CTL Responses.
26926362Prostaglandins Leukot. Essent. Fatty Acids2016Bonanno A et al.Prostaglandin E₂ possesses different potencies in inducing Vascular Endothelial Growth Factor and Interleukin-8 production in COPD human lung fibroblasts.
26902402Phytomedicine2016Rosa SI et al.Vitexin reduces neutrophil migration to inflammatory focus by down-regulating pro-inflammatory mediators via inhibition of p38, ERK1/2 and JNK pathway.
26888865Cancer Prev Res (Phila)2016Maeda Y et al.Myeloid Differentiation Factor 88 Signaling in Bone Marrow-Derived Cells Promotes Gastric Tumorigenesis by Generation of Inflammatory Microenvironment.
26851122Bone2016Fujiwara M et al.Successful induction of sclerostin in human-derived fibroblasts by 4 transcription factors and its regulation by parathyroid hormone, hypoxia, and prostaglandin E2.
26850138Exp. Cell Res.2016Kasai T et al.Role of OATP2A1 in PGE(2) secretion from human colorectal cancer cells via exocytosis in response to oxidative stress.
26841868J. Biol. Chem.2016Yun B et al.Prostaglandins from Cytosolic Phospholipase A2α/Cyclooxygenase-1 Pathway and Mitogen-activated Protein Kinases Regulate Gene Expression in Candida albicans-infected Macrophages.
26817629Endocr. Relat. Cancer2016Swami S et al.Vitamin D mitigates the adverse effects of obesity on breast cancer in mice.
26779946Fitoterapia2016Zhang L et al.Anti-inflammatory cyclopentene derivatives from the inner bark of Tabebuia avellanedae.
26744410Clin. Sci.2016Evans IC et al.Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis.
26644581Proc. Natl. Acad. Sci. U.S.A.2015Luan B et al.CREB pathway links PGE2 signaling with macrophage polarization.
26610096Int. Immunopharmacol.2016Victoni T et al.Roflumilast n-oxide associated with PGE2 prevents the neutrophil elastase-induced production of chemokines by epithelial cells.
26608124Neuroscience2016Simm B et al.Effects of prostaglandin E2 on cells cultured from the rat organum vasculosum laminae terminalis and median preoptic nucleus.
26596719J Biomech2015Liu C et al.Mechanical loading up-regulates early remodeling signals from osteocytes subjected to physical damage.
26592483Pharmacol. Res.2016Lopes AH et al.DF2755A, a novel non-competitive allosteric inhibitor of CXCR1/2, reduces inflammatory and post-operative pain.
26577025Reproduction2016Przygrodzka E et al.Steroid hormones, prostanoids, and angiogenic systems during rescue of the corpus luteum in pigs.
26547885Vet. Immunol. Immunopathol.2015Wyns H et al.Modulation by gamithromycin and ketoprofen of in vitro and in vivo porcine lipopolysaccharide-induced inflammation.
26543101Arterioscler. Thromb. Vasc. Biol.2016Gao C et al.Microsomal Prostaglandin E Synthase-1-Derived PGE2 Inhibits Vascular Smooth Muscle Cell Calcification.
26472924J. Biol. Chem.2015Fang Y et al.The Nogo/Nogo Receptor (NgR) Signal Is Involved in Neuroinflammation through the Regulation of Microglial Inflammatory Activation.
26432356Cell. Signal.2015Taub M et al.Renal proximal tubule Na,K-ATPase is controlled by CREB-regulated transcriptional coactivators as well as salt-inducible kinase 1.
26403276Biochim. Biophys. Acta2015Blirando K et al.The stellate vascular smooth muscle cell phenotype is induced by IL-1β via the secretion of PGE2 and subsequent cAMP-dependent protein kinase A activation.
26349412Theriogenology2015Bartlewski PM and Candappa IBAssessing the usefulness of prostaglandin E2 (Cervidil) for transcervical artificial insemination in ewes.
26311764J. Neurosci.2015Lacroix A et al.COX-2-Derived Prostaglandin E2 Produced by Pyramidal Neurons Contributes to Neurovascular Coupling in the Rodent Cerebral Cortex.
26261008Gastroenterology2015Wang D et al.Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice.
26240416Reproduction2015Gram A et al.Expression and functional implications of luteal endothelins in pregnant and non-pregnant dogs.
26216515Mol. Ther.2015Reading JL et al.Suppression of IL-7-dependent Effector T-cell Expansion by Multipotent Adult Progenitor Cells and PGE2.
26183771FASEB J.2015Kirkby NS et al.Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation.
26157044J. Pharmacol. Exp. Ther.2015Wang D et al.Activation of Mas Oncogene-Related G Protein-Coupled Receptors Inhibits Neurochemical Alterations in the Spinal Dorsal Horn and Dorsal Root Ganglia Associated with Inflammatory Pain in Rats.
26122134Int. Immunopharmacol.2015Lee S et al.Sappanone A exhibits anti-inflammatory effects via modulation of Nrf2 and NF-κB.
26119525Toxicol In Vitro2015Gutowska I et al.Fluoride as a factor initiating and potentiating inflammation in THP1 differentiated monocytes/macrophages.
26113609Endocr. Relat. Cancer2015Finetti F et al.mPGES-1 in prostate cancer controls stemness and amplifies epidermal growth factor receptor-driven oncogenicity.
26100595Int. J. Biochem. Cell Biol.2015Pelissier-Rota MA et al.Nicotine-induced cellular stresses and autophagy in human cancer colon cells: A supportive effect on cell homeostasis via up-regulation of Cox-2 and PGE(2) production.
26079093Exp. Physiol.2015Ali SS et al.Effects of different routes of nicotine administration on gastric morphology and hormonal secretion in rats.
26065856FASEB J.2015Amadio P et al.Production of prostaglandin E2 induced by cigarette smoke modulates tissue factor expression and activity in endothelial cells.
26063630Naunyn Schmiedebergs Arch. Pharmacol.2015Granato C et al.Prostaglandin E2 excitatory effects on rat urinary bladder: a comparison between the β-adrenoceptor modulation of non-voiding activity in vivo and micro-contractile activity in vitro.
26020725Mol. Endocrinol.2015Berthou F et al.The Tpl2 Kinase Regulates the COX-2/Prostaglandin E2 Axis in Adipocytes in Inflammatory Conditions.
26004410Curr. Pharm. Des.2015Takeuchi K et al.Regulatory mechanism of the gastric hyperemic response following barrier disruption: roles of cyclooxygenase-1, the prostaglandin E2/EP1 receptor and sensory neurons.
25997851J Neuroinflammation2015Carlson NG et al.The role of the prostaglandin E2 receptors in vulnerability of oligodendrocyte precursor cells to death.
25962903J. Allergy Clin. Immunol.2015Säfholm J et al.Prostaglandin E2 inhibits mast cell-dependent bronchoconstriction in human small airways through the E prostanoid subtype 2 receptor.
25903377BMC Musculoskelet Disord2015Ferrándiz ML et al.Effects of BIS076 in a model of osteoarthritis induced by anterior cruciate ligament transection in ovariectomised rats.
25865800Exp. Dermatol.2015Saalbach A et al.Fibroblasts support migration of monocyte-derived dendritic cells by secretion of PGE2 and MMP-1.
25772215Expert Opin Ther Pat2015Ganesh TEvaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.
25771128Toxicol. Appl. Pharmacol.2015Wrobel MH et al.The adverse effects of aldrin and dieldrin on both myometrial contractions and the secretory functions of bovine ovaries and uterus in vitro.
25753843Immunopharmacol Immunotoxicol2015El Morsy EM et al.Attenuating effects of coenzyme Q10 and amlodipine in ulcerative colitis model in rats.
25711428Life Sci.2015Amoruso A et al.Characterization of the anti-inflammatory properties of NCX 429, a dual-acting compound releasing nitric oxide and naproxen.
25701505Int. Immunopharmacol.2015Byun EB et al.Gamma-irradiated resveratrol negatively regulates LPS-induced MAPK and NF-κB signaling through TLR4 in macrophages.
25686984Mater Sci Eng C Mater Biol Appl2015Murni NS et al.Cytotoxicity evaluation of biodegradable Zn-3Mg alloy toward normal human osteoblast cells.
25683963Am. J. Obstet. Gynecol.2015Falsetta ML et al.Identification of novel mechanisms involved in generating localized vulvodynia pain.
25681768Biochem. Biophys. Res. Commun.2015Toki Y et al.Extracellular ATP induces P2X7 receptor activation in mouse Kupffer cells, leading to release of IL-1β, HMGB1, and PGE2, decreased MHC class I expression and necrotic cell death.
25630423Dig. Dis. Sci.2015Baird AC et al.Prostaglandin E₂ and polyenylphosphatidylcholine protect against intestinal fibrosis and regulate myofibroblast function.
25589745J. Neurosci.2015Ferrari LF et al.Accounting for the delay in the transition from acute to chronic pain: axonal and nuclear mechanisms.
25585231Int. Immunopharmacol.2015Reddy SA et al.Sulforaphane and its methylcarbonyl analogs inhibit the LPS-stimulated inflammatory response in human monocytes through modulating cytokine production, suppressing chemotactic migration and phagocytosis in a NF-κB- and MAPK-dependent manner.
25557876Exp. Cell Res.2015Yang C et al.CYP2S1 depletion enhances colorectal cell proliferation is associated with PGE2-mediated activation of β-catenin signaling.
25554493Neurobiol. Aging2015Ko CY et al.CCAAT/enhancer-binding protein delta/miR135a/thrombospondin 1 axis mediates PGE2-induced angiogenesis in Alzheimer's disease.
25451282Neuroscience2015Miranda J et al.Effect of pain chronification and chronic pain on an endogenous pain modulation circuit in rats.
25448500Int. Immunopharmacol.2014Yoon CS et al.Anti-neuroinflammatory effect of aurantiamide acetate from the marine fungus Aspergillus sp. SF-5921: inhibition of NF-κB and MAPK pathways in lipopolysaccharide-induced mouse BV2 microglial cells.
25310697PLoS ONE2014Peacock O et al.Inflammation and MiR-21 pathways functionally interact to downregulate PDCD4 in colorectal cancer.
25257209Bioessays2014Hurle JMRegenerative versus destructive cell death in developing systems and tissue homeostasis (retrospective on DOI 10.1002/bies.201200018).
25241065Neuroscience2014Grace PM et al.Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae.
25205726Biol. Chem.2015Maeda Y et al.Mechanisms for proteinase-activated receptor 1-triggered prostaglandin E2 generation in mouse osteoblastic MC3T3-E1 cells.
25118941Mol Med Rep2014Bao JP et al.Visceral adipose tissue-derived serine protease inhibitor inhibits interleukin-1β-induced catabolic and inflammatory responses in murine chondrocytes.
25110109Mol Med Rep2014Liu N et al.Helicobacter pylori promotes VEGF expression via the p38 MAPK‑mediated COX‑2‑PGE2 pathway in MKN45 cells.
25068824Int. Immunopharmacol.2014Jakhar R et al.Morin hydrate augments phagocytosis mechanism and inhibits LPS induced autophagic signaling in murine macrophage.
25055744Clin Oral Investig2015Zara S et al.Zoledronic acid at subtoxic dose extends osteoblastic stage span of primary human osteoblasts.
24977486Cell. Physiol. Biochem.2014Pastukhov O et al.Ceramide kinase contributes to proliferation but not to prostaglandin E2 formation in renal mesangial cells and fibroblasts.
24894428Clin. Exp. Immunol.2014Hodge G et al.Lung cancer is associated with decreased expression of perforin, granzyme B and interferon (IFN)-γ by infiltrating lung tissue T cells, natural killer (NK) T-like and NK cells.
24861422J. Neurosci. Methods2014Gruen M et al.Use of dynamic weight bearing as a novel end-point for the assessment of abdominal pain in the LPS-induced peritonitis model in the rat.
24839005Tumour Biol.2014Jongthawin J et al.PGE2 signaling and its biosynthesis-related enzymes in cholangiocarcinoma progression.
24824317BJOG2015Grobman WAIs it time for outpatient cervical ripening with prostaglandins?
24768319Mol. Immunol.2015Torres R et al.The PGE2-EP2-mast cell axis: an antiasthma mechanism.
24726877Immunity2014Coulombe F et al.Targeted prostaglandin E2 inhibition enhances antiviral immunity through induction of type I interferon and apoptosis in macrophages.
24689881J. Nat. Prod.2014Pyee Y et al.Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
24614812Clin Obstet Gynecol2014Goetzl LMethods of cervical ripening and labor induction: pharmacologic.
24467543Am. J. Chin. Med.2014Park EY et al.Efficacy comparison of Korean ginseng and American ginseng on body temperature and metabolic parameters.
24418675Osteoarthr. Cartil.2014Li TF et al.BMP-2 induces ATF4 phosphorylation in chondrocytes through a COX-2/PGE2 dependent signaling pathway.
24397441J. Matern. Fetal. Neonatal. Med.2014Wang W et al.Which is the safer method of labor induction for oligohydramnios women? Transcervical double balloon catheter or dinoprostone vaginal insert.
24378735Mol. Cell. Endocrinol.2014Fujimori K et al.Termination mechanism of CREB-dependent activation of COX-2 expression in early phase of adipogenesis.
24355567Biochem. Pharmacol.2014Schiffmann S et al.PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis.
24338998Mol Nutr Food Res2014Kim MS et al.Phloretin suppresses thrombin-mediated leukocyte-platelet-endothelial interactions.
24333565Exp. Neurol.2014Kaushik MK et al.Prostaglandin D(2) is crucial for seizure suppression and postictal sleep.
24229710Cancer Cell2013Katoh H et al.CXCR2-expressing myeloid-derived suppressor cells are essential to promote colitis-associated tumorigenesis.
24157494J Perinatol2014Faucett AM et al.Oral misoprostol versus vaginal dinoprostone for labor induction in nulliparous women at term.
24133101Am. J. Physiol. Regul. Integr. Comp. Physiol.2013Tanaka M et al.Role of an excitatory preoptic-raphé pathway in febrile vasoconstriction of the rat's tail.
24132147Int J Mol Sci2013Cho HJ et al.Erucin exerts anti-inflammatory properties in murine macrophages and mouse skin: possible mediation through the inhibition of NFκB signaling.
24127286Mol. Carcinog.2015Woo SM et al.Silymarin suppresses the PGE2 -induced cell migration through inhibition of EP2 activation; G protein-dependent PKA-CREB and G protein-independent Src-STAT3 signal pathways.
24118119J. Clin. Periodontol.2013Sánchez GA et al.Salivary IL-1β and PGE2 as biomarkers of periodontal status, before and after periodontal treatment.
24074742Nutr Res2013Zhang D et al.Modified apple polysaccharides suppress the migration and invasion of colorectal cancer cells induced by lipopolysaccharide.
24060896Hypertension2013Ren Y et al.Prostaglandin E2 mediates connecting tubule glomerular feedback.
24001404BMC Gastroenterol2013Wang Q et al.Protective effects of N-acetylcysteine on acetic acid-induced colitis in a porcine model.
23873014Med. Oncol.2013Li T et al.Colorectal carcinoma-derived fibroblasts modulate natural killer cell phenotype and antitumor cytotoxicity.
23872719Inflammation2013Pathak NN et al.Antihyperalgesic and anti-inflammatory effects of atorvastatin in chronic constriction injury-induced neuropathic pain in rats.
23859562Langmuir2013Majumder J et al.β-Amino acid and amino-alcohol conjugation of a nonsteroidal anti-inflammatory drug (NSAID) imparts hydrogelation displaying remarkable biostability, biocompatibility, and anti-inflammatory properties.
23835093Regul. Pept.2013Kutina AV et al.Vasotocin analogues with selective natriuretic, kaliuretic and antidiuretic effects in rats.
23810444Int. Immunopharmacol.2013Shao J et al.7b, a novel naphthalimide derivative, exhibited anti-inflammatory effects via targeted-inhibiting TAK1 following down-regulation of ERK1/2- and p38 MAPK-mediated activation of NF-κB in LPS-stimulated RAW264.7 macrophages.
23806288Arch. Oral Biol.2013Wu Y et al.The osteogenic differentiation of PDLSCs is mediated through MEK/ERK and p38 MAPK signalling under hypoxia.
23796953Trends Pharmacol. Sci.2013Jiang J and Dingledine RProstaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection.
23766070Mol Nutr Food Res2013You S et al.Inhibitory effects and molecular mechanisms of garlic organosulfur compounds on the production of inflammatory mediators.
23756451Anesthesiology2013Sun Y et al.Epigenetic regulation of spinal CXCR2 signaling in incisional hypersensitivity in mice.
23682071Cancer Prev Res (Phila)2013Mikulec CD et al.The chemopreventive efficacies of nonsteroidal anti-inflammatory drugs: the relationship of short-term biomarkers to long-term skin tumor outcome.
23639875Bone2013Choudhary S et al.Prostaglandin E2 acts via bone marrow macrophages to block PTH-stimulated osteoblast differentiation in vitro.
23622726J. Surg. Res.2013Wu BG et al.High-lipid enteral nutrition could partially mitigate inflammation but not lung injury in hemorrhagic shock rats.
23619528Pharmacol. Res.2013Hussain M et al.Multilevel pharmacological manipulation of adenosine-prostaglandin E₂/cAMP nexus in the tumor microenvironment: a 'two hit' therapeutic opportunity.
23586622J. Periodont. Res.2013Mizutani H et al.Lipopolysaccharide of Aggregatibacter actinomycetemcomitans up-regulates inflammatory cytokines, prostaglandin E2 synthesis and osteoclast formation in interleukin-1 receptor antagonist-deficient mice.
23517855Anim. Reprod. Sci.2013Parillo F et al.Aglepristone (RU534) effects on luteal function of pseudopregnant rabbits: steroid receptors, enzymatic activities, and hormone productions in corpus luteum and uterus.
23490068Prostaglandins Leukot. Essent. Fatty Acids2013Standley RA et al.Prostaglandin E2 induces transcription of skeletal muscle mass regulators interleukin-6 and muscle RING finger-1 in humans.
23485729Mol. Cell. Endocrinol.2013Stratakis CAcAMP/PKA signaling defects in tumors: genetics and tissue-specific pluripotential cell-derived lesions in human and mouse.
23470625Am. J. Respir. Cell Mol. Biol.2013Garrison G et al.Reversal of myofibroblast differentiation by prostaglandin E(2).
23419768Prostaglandins Leukot. Essent. Fatty Acids2013Jones RL et al.Nature of the slow relaxation of smooth muscle induced by a EP2 receptor agonist with a non-prostanoid structure.
23343963Digestion2013Tsujii MCyclooxygenase, cancer stem cells and DNA methylation play important roles in colorectal carcinogenesis.
23298698Pharmacol. Res.2013Torres R et al.Locally administered prostaglandin E2 prevents aeroallergen-induced airway sensitization in mice through immunomodulatory mechanisms.
23246486Int. J. Biochem. Cell Biol.2013Peng Y et al.Prostaglandin E2 induces stromal cell-derived factor-1 expression in prostate stromal cells by activating protein kinase A and transcription factor Sp1.
23243000Mol. Biol. Cell2013Cho T et al.Apolipoprotein(a) stimulates nuclear translocation of β-catenin: a novel pathogenic mechanism for lipoprotein(a).
23235695Cell. Physiol. Biochem.2012Ji YR et al.Mesenchymal stem cells support proliferation and terminal differentiation of B cells.
23230009Plant Foods Hum Nutr2012Bony E et al.Chemical composition and anti-inflammatory properties of the unsaponifiable fraction from awara (Astrocaryum vulgare M.) pulp oil in activated J774 macrophages and in a mice model of endotoxic shock.
23149922Cancer Res.2013Ho MY et al.MIG-7 controls COX-2/PGE2-mediated lung cancer metastasis.
23143054Shock2012Brogliato AR et al.Ketoprofen impairs immunosuppression induced by severe sepsis and reveals an important role for prostaglandin E2.
23029468PLoS ONE2012Liu L et al.H(2)S-releasing aspirin protects against aspirin-induced gastric injury via reducing oxidative stress.
22995857Nitric Oxide2013Alves DP et al.NO/cGMP production is important for the endogenous peripheral control of hyperalgesia during inflammation.
22969117Cancer Discov2012Räsänen K and Herlyn MParacrine signaling between carcinoma cells and mesenchymal stem cells generates cancer stem cell niche via epithelial-mesenchymal transition.
22914655J. Neurophysiol.2012Alvarez P et al.IB4(+) nociceptors mediate persistent muscle pain induced by GDNF.
22835428Int. Immunopharmacol.2012Wang D et al.Paeoniflorin inhibits function and down-regulates HLA-DR and CD80 expression of human peripheral blood monocytes stimulated by rhIL-1β.
22773695Am. J. Physiol. Lung Cell Mol. Physiol.2012Lin CC et al.Adenosine triphosphate regulates NADPH oxidase activity leading to hydrogen peroxide production and COX-2/PGE2 expression in A549 cells.
22749501Placenta2012Peltier MR et al.Polybrominated diphenyl ethers enhance the production of proinflammatory cytokines by the placenta.
22728165Int. J. Biochem. Cell Biol.2012Miao L et al.Prostaglandin E2 stimulates S100A8 expression by activating protein kinase A and CCAAT/enhancer-binding-protein-beta in prostate cancer cells.
22658594Curr. Biol.2012Feng Y et al.Live imaging of tumor initiation in zebrafish larvae reveals a trophic role for leukocyte-derived PGE₂.
22645246FASEB J.2012Huang SK et al.Prostaglandin E₂ increases fibroblast gene-specific and global DNA methylation via increased DNA methyltransferase expression.
22637723J. Pharmacol. Exp. Ther.2012Rim HK et al.Nodakenin suppresses lipopolysaccharide-induced inflammatory responses in macrophage cells by inhibiting tumor necrosis factor receptor-associated factor 6 and nuclear factor-κB pathways and protects mice from lethal endotoxin shock.
22614640Ann Biomed Eng2012Speich JE et al.Carbachol-induced volume adaptation in mouse bladder and length adaptation via rhythmic contraction in rabbit detrusor.
22565056Cell. Immunol.Bruckner M et al.Distinct modulation of chemokine expression patterns in human monocyte-derived dendritic cells by prostaglandin E(2).
22537108J. Neurochem.2012Shin JH et al.Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis.
22394009J. Dermatol.2012Sato T et al.Novel anti-acne actions of nadifloxacin and clindamycin that inhibit the production of sebum, prostaglandin E(2) and promatrix metalloproteinase-2 in hamster sebocytes.
22351930J. Exp. Med.2012Scarlett UK et al.Ovarian cancer progression is controlled by phenotypic changes in dendritic cells.
22333568Biochem. Biophys. Res. Commun.2012Hegyi B et al.Activated T-cells and pro-inflammatory cytokines differentially regulate prostaglandin E2 secretion by mesenchymal stem cells.
22298530Am. J. Respir. Cell Mol. Biol.2012Nakanishi M et al.Prostaglandin E2 stimulates the production of vascular endothelial growth factor through the E-prostanoid-2 receptor in cultured human lung fibroblasts.
22187483J. Immunol.2012Kalinski PRegulation of immune responses by prostaglandin E2.
22182446Cancer Lett.2012Li T et al.Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO.
22133644Phytochemistry2012Zhang X et al.Bauer ketones 23 and 24 from Echinacea paradoxa var. paradoxa inhibit lipopolysaccharide-induced nitric oxide, prostaglandin E2 and cytokines in RAW264.7 mouse macrophages.
22072539Phytother Res2012Fiebich BL et al.Molecular targets of the antiinflammatory Harpagophytum procumbens (devil's claw): inhibition of TNFα and COX-2 gene expression by preventing activation of AP-1.
22048090J Bone Joint Surg Am2011Stålman A et al.Temperature-sensitive release of prostaglandin E₂ and diminished energy requirements in synovial tissue with postoperative cryotherapy: a prospective randomized study after knee arthroscopy.
21989206Life Sci.2011Lee MJ et al.Anti-inflammatory effect of transduced PEP-1-cyclophilin A in Raw264.7 cells and 12-O-tetradecanoylphorbol-13-acetate-induced mice.
21957456PLoS ONE2011Rudnick JA et al.Functional heterogeneity of breast fibroblasts is defined by a prostaglandin secretory phenotype that promotes expansion of cancer-stem like cells.
21951555Am. J. Reprod. Immunol.2012Soleymaninejadian E et al.Immunomodulatory properties of mesenchymal stem cells: cytokines and factors.
21929606Vet Ophthalmol2011Pinard CL et al.Measurements of canine aqueous humor inflammatory mediators and the effect of carprofen following anterior chamber paracentesis.
21926111Carcinogenesis2011Roberts HR et al.Colon tumour cells increase PGE(2) by regulating COX-2 and 15-PGDH to promote survival during the microenvironmental stress of glucose deprivation.
21913318J Biomed Mater Res A2011Geng DC et al.Protection against titanium particle-induced osteoclastogenesis by cyclooxygenase-2 selective inhibitor.
21907186Biochem. Biophys. Res. Commun.2011Choi HJ et al.Induction of human microsomal prostaglandin E synthase 1 by activated oncogene RhoA GTPase in A549 human epithelial cancer cells.
21889965Peptides2011Kang YA et al.Novel anti-inflammatory peptides as cosmeceutical peptides.
21884514Clin Transl Sci2011Barrie A et al.Prostaglandin E2 and IL-23 plus IL-1β differentially regulate the Th1/Th17 immune response of human CD161(+) CD4(+) memory T cells.
21872518J Pediatr Adolesc Gynecol2011Kauschansky A et al.Insight: prolonged vaginal bleeding during central precocious puberty therapy with a long-acting gonadotropin-releasing hormone agonist: a proposed mechanism and management plan.
21839184Int. Immunopharmacol.2011Oh KS et al.Salvianolic acid A suppress lipopolysaccharide-induced NF-κB signaling pathway by targeting IKKβ.
21781136J. Vet. Pharmacol. Ther.2012Pelligand L et al.Development and validation of a tissue cage model of acute inflammation in the cat.
21742035Neurobiol. Dis.2012Beaulieu D et al.Abnormal prostaglandin E2 production blocks myogenic differentiation in myotonic dystrophy.
21699795Gastroenterology2011Bimczok D et al.Stromal regulation of human gastric dendritic cells restricts the Th1 response to Helicobacter pylori.
21622871J. Anim. Sci.2011Lopes CN et al.Strategic supplementation of calcium salts of polyunsaturated fatty acids to enhance reproductive performance of Bos indicus beef cows.
21596094Neurosci. Lett.2011Rusyniak DE et al.The role of orexin-1 receptors in physiologic responses evoked by microinjection of PgE2 or muscimol into the medial preoptic area.
21519044Anesth. Analg.2011Kohno TZaltoprofen inhibits bradykinin-mediated enhancement of glutamate receptor activity in substantia gelatinosa neurons.
21487892J. Clin. Immunol.2011Schwandt A et al.Clinical and immunomodulatory effects of celecoxib plus interferon-alpha in metastatic renal cell carcinoma patients with COX-2 tumor immunostaining.
21448417World J. Gastroenterol.2011Nassar NN et al.Octreotide ameliorates gastric lesions in chronically mild stressed rats.
21426847Zhonghua Yan Ke Za Zhi2011Yi WS and Xu XL[Effects of LPS-induced inflammation on differentiation of orbital pre-adipocytes in thyroid-associated ophthalmopathy].
21371033J. Neurochem.2011St-Jacques B and Ma WRole of prostaglandin E2 in the synthesis of the pro-inflammatory cytokine interleukin-6 in primary sensory neurons: an in vivo and in vitro study.
21277863Life Sci.2011Pavan B et al.Estrogen metabolites in the release of inflammatory mediators from human amnion-derived cells.
21277243Eur J Pain2011Diers M et al.Differential central pain processing following repetitive intramuscular proton/prostaglandin E₂ injections in female fibromyalgia patients and healthy controls.
21253954J Asian Nat Prod Res2011Wang JF et al.Anti-inflammatory flavonolignans from Hydnocarpus anthelminthica seeds.
21199162Respirology2011Zhang W et al.Cigarette smoke modulates PGE(2) and host defence against Moraxella catarrhalis infection in human airway epithelial cells.
21177120Cytokine2011Osborn O et al.Ccl22/MDC, is a prostaglandin dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue.
21133897Br. J. Pharmacol.2011Malvar Ddo C et al.The antipyretic effect of dipyrone is unrelated to inhibition of PGE(2) synthesis in the hypothalamus.
21077941Fundam Clin Pharmacol2011Zhang X et al.Effects of florfenicol on LPS-induced nitric oxide and prostaglandin E₂ production in RAW 264.7 macrophages.
21058188Nutr Cancer2010Guo W et al.Avenanthramides inhibit proliferation of human colon cancer cell lines in vitro.
20969958Pharmacol. Res.2011Fornai M et al.Effects of esomeprazole on healing of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers in the presence of a continued NSAID treatment: Characterization of molecular mechanisms.
20951077Oral Oncol.2010Abrahao AC et al.A role for COX2-derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation.
20883838Acta Biomater2011Kim KS et al.Injectable hyaluronic acid-tyramine hydrogels for the treatment of rheumatoid arthritis.
20857911J. Med. Chem.2010Rubner G et al.Synthesis and biological activities of transition metal complexes based on acetylsalicylic acid as neo-anticancer agents.
20643206Cell. Signal.2011Oberprieler NG and Taskén KAnalysing phosphorylation-based signalling networks by phospho flow cytometry.
20600778Exp. Gerontol.2010Myer RG et al.Prostaglandin E2-dependent IL-23 production in aged murine dendritic cells.
20599217J. Surg. Res.2010Moon SW et al.Concentration of arginine and optimal time of hypertonic saline in restoration of T-cell dysfunction.
20571855Ann Biomed Eng2010Nakamura T et al.Effects of low-intensity pulsed ultrasound on the expression and activity of hyaluronan synthase and hyaluronidase in IL-1β-stimulated synovial cells.
20552344Methods Mol. Biol.2010Ferrario A and Gomer CJTargeting the tumor microenvironment using photodynamic therapy combined with inhibitors of cyclooxygenase-2 or vascular endothelial growth factor.
20079660Trends Endocrinol. Metab.2010Blackwell KA et al.Prostaglandins in bone: bad cop, good cop?
19969421Pain2010Pinto LG et al.IL-17 mediates articular hypernociception in antigen-induced arthritis in mice.
19788928Int. J. Biochem. Cell Biol.2010Legler DF et al.Prostaglandin E2 at new glance: novel insights in functional diversity offer therapeutic chances.
19467701Biomaterials2009Chang MC et al.The effect of BisGMA on cyclooxygenase-2 expression, PGE2 production and cytotoxicity via reactive oxygen species- and MEK/ERK-dependent and -independent pathways.
19376214Toxicol. Lett.2009Ridley W and Matsuoka MFluoride-induced cyclooxygenase-2 expression and prostaglandin E2 production in A549 human pulmonary epithelial cells.
19233324Bone2009Minamizaki T et al.EP2 and EP4 receptors differentially mediate MAPK pathways underlying anabolic actions of prostaglandin E2 on bone formation in rat calvaria cell cultures.
18718465Exp. Cell Res.2008Clarkin CE et al.Heterotypic contact reveals a COX-2-mediated suppression of osteoblast differentiation by endothelial cells: A negative modulatory role for prostanoids in VEGF-mediated cell: cell communication?
18562087Mol. Cell. Endocrinol.2008Kaczmarek MM et al.Assessment of VEGF-receptor system expression in the porcine endometrial stromal cells in response to insulin-like growth factor-I, relaxin, oxytocin and prostaglandin E2.
18054559Gastroenterology2007Fukata M et al.Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors.
17825413Mol. Immunol.2008Scott T and Owens MDThrombocytes respond to lipopolysaccharide through Toll-like receptor-4, and MAP kinase and NF-kappaB pathways leading to expression of interleukin-6 and cyclooxygenase-2 with production of prostaglandin E2.
17678966Int. Rev. Neurobiol.2007Minghetti L and Pocchiari MCyclooxygenase-2, prostaglandin E2, and microglial activation in prion diseases.
17604006Brain Res.2007Machado RR et al.CCR1 and CCR5 chemokine receptors are involved in fever induced by LPS (E. coli) and RANTES in rats.
17493609Exp. Cell Res.2007Birukova AA et al.Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation.
17229575Pharmacol. Res.2007Kang OH et al.Ethyl acetate extract from Angelica Dahuricae Radix inhibits lipopolysaccharide-induced production of nitric oxide, prostaglandin E2 and tumor necrosis factor-alphavia mitogen-activated protein kinases and nuclear factor-kappaB in macrophages.
17188523Osteoarthr. Cartil.2007Syggelos SA et al.In vitro effects of non-steroidal anti-inflammatory drugs on cytokine, prostanoid and matrix metalloproteinase production by interface membranes from loose hip or knee endoprostheses.
17088072Cytokine2006Melgar S et al.Local production of chemokines and prostaglandin E2 in the acute, chronic and recovery phase of murine experimental colitis.
16859832Biochim. Biophys. Acta2006Chell S et al.Mediators of PGE2 synthesis and signalling downstream of COX-2 represent potential targets for the prevention/treatment of colorectal cancer.
16828555Bioorg. Med. Chem.2006Cho H et al.Role of glutamine 148 of human 15-hydroxyprostaglandin dehydrogenase in catalytic oxidation of prostaglandin E2.
16650804Trends Mol Med2006Chan TAProstaglandins and the colon cancer connection.
16600409Neurosci. Res.2006Dai YQ et al.Triptolide inhibits COX-2 expression via NF-kappa B pathway in astrocytes.
16546299Neurochem. Int.2006Hüll M et al.Amyloid beta peptide (25-35) activates protein kinase C leading to cyclooxygenase-2 induction and prostaglandin E2 release in primary midbrain astrocytes.
16337744Cancer Treat. Rev.2006Wu TCyclooxygenase-2 in hepatocellular carcinoma.
16278065Cell. Signal.2006Luo SF et al.Induction of cytosolic phospholipase A2 by lipopolysaccharide in canine tracheal smooth muscle cells: involvement of MAPKs and NF-kappaB pathways.
16275389J. Allergy Clin. Immunol.2005Kanda N et al.IL-17 suppresses TNF-alpha-induced CCL27 production through induction of COX-2 in human keratinocytes.
16188227Biochem. Biophys. Res. Commun.2005Matsumura S et al.Rho-kinase mediates spinal nitric oxide formation by prostaglandin E2 via EP3 subtype.
15978547Biochem. Pharmacol.2005Zeddou M et al.Prostaglandin E2 induces the expression of functional inhibitory CD94/NKG2A receptors in human CD8+ T lymphocytes by a cAMP-dependent protein kinase A type I pathway.
15804596Cytokine2005Belibasakis GN et al.Cytokine responses of human gingival fibroblasts to Actinobacillus actinomycetemcomitans cytolethal distending toxin.
15727891Osteoarthr. Cartil.2005Salvat C et al.Immature murine articular chondrocytes in primary culture: a new tool for investigating cartilage.
15664007Bone2005Ghayor C et al.Prostaglandin-dependent activation of ERK mediates cell proliferation induced by transforming growth factor beta in mouse osteoblastic cells.
15547544Am. J. Obstet. Gynecol.2004Buhimschi IA et al.Physical and biomechanical characteristics of rat cervical ripening are not consistent with increased collagenase activity.
15207747Bone2004Wang FS et al.Nitric oxide mediates ultrasound-induced hypoxia-inducible factor-1alpha activation and vascular endothelial growth factor-A expression in human osteoblasts.
15196696Mol. Cell. Endocrinol.2004Andersson AK et al.Cytokine-induced PGE(2) formation is reduced from iNOS deficient murine islets.
15086901Kidney Int.2004Quan S et al.Expression of human heme oxygenase-1 in the thick ascending limb attenuates angiotensin II-mediated increase in oxidative injury.
14527510Cell. Immunol.2003Vassiliou E et al.Prostaglandin E2 inhibits TNF production in murine bone marrow-derived dendritic cells.
12967650CytokineGrandjean-Laquerriere A et al.Differential regulation of TNF-alpha, IL-6 and IL-10 in UVB-irradiated human keratinocytes via cyclic AMP/protein kinase A pathway.
12631112Kidney Int.2003Yamagishi S et al.Advanced glycation end products inhibit de novo protein synthesis and induce TGF-beta overexpression in proximal tubular cells.
12620660Eur J Med Chem2003Balsamo A et al.Synthesis of heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors: effects on the inhibitory activity of the replacement of the cyclopentene central core with pyrazole, thiophene or isoxazole ring.
12573511Brain Res.2003Ranels HJ and Griffin JDThe effects of prostaglandin E2 on the firing rate activity of thermosensitive and temperature insensitive neurons in the ventromedial preoptic area of the rat hypothalamus.
12493622Brain Res.2003Yagami T et al.Prostaglandin E2 rescues cortical neurons from amyloid beta protein-induced apoptosis.
12445196J. Invest. Dermatol.2002Kanda N and Watanabe SCyclooxygenase-2 inhibitor enhances whereas prostaglandin E2 inhibits the production of interferon-induced protein of 10 kDa in epidermoid carcinoma A431.
12009501Neurobiol. AgingScali C et al.Neutrophils CD11b and fibroblasts PGE(2) are elevated in Alzheimer's disease.
11738136Neuroscience2001Ben-Hur T et al.A novel permissive role for glucocorticoids in induction of febrile and behavioral signs of experimental herpes simplex virus encephalitis.
11375954Gastroenterology2001Barbara G et al.Role of immunologic factors and cyclooxygenase 2 in persistent postinfective enteric muscle dysfunction in mice.
11323142Pain2001Vetter G et al.Release of glutamate, nitric oxide and prostaglandin E2 and metabolic activity in the spinal cord of rats following peripheral nociceptive stimulation.
11257456Cell. Signal.2001Bordin S and Tan XC1q arrests the cell cycle progression of fibroblasts in G(1) phase: role of the cAMP/PKA-I pathway.
10869485Arch. Oral Biol.2000Genaro AM et al.Involvement of the endogenous nitric oxide signalling system in bradykinin receptor activation in rat submandibular salivary gland.
10802063FEBS Lett.2000Hasegawa H et al.Different membrane targeting of prostaglandin EP3 receptor isoforms dependent on their carboxy-terminal tail structures.
10709995Bone2000Sakai R et al.Activin release from bone coupled to bone resorption in organ culture of neonatal mouse calvaria.
10661500Brain Res.2000Watanabe T et al.Angiotensin AT1 receptors in the preoptic area negatively modulate the cardiovascular and ACTH responses induced in rats by intrapreoptic injection of prostaglandin E2.
10400344Bioorg. Med. Chem.1999Gil L et al.Prostaglandin E2-bisphosphonate conjugates: potential agents for treatment of osteoporosis.
10397448Cancer Lett.1998Kökoğlu E et al.Prostaglandin E2 levels in human brain tumor tissues and arachidonic acid levels in the plasma membrane of human brain tumors.
10216171Brain Res.1999Thornhill J and Asselin JThe effect of head cooling on the physiological responses and resultant neural damage to global hemispheric hypoxic ischemia in prostaglandin E2 treated rats.
9809657Peptides1998Marquet F et al.Effect of sorbin derivatives on cholera toxin-induced intestinal secretion in rat in vivo.
9729377Brain Res. Mol. Brain Res.1998Liu Y et al.Taurine chloramine inhibits production of nitric oxide and prostaglandin E2 in activated C6 glioma cells by suppressing inducible nitric oxide synthase and cyclooxygenase-2 expression.
9067636Cell. Signal.1997Sellmayer A et al.Intrinsic cyclooxygenase activity is not required for monocytic differentiation of U937 cells.