PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

References related to genes published in Others

PMID	Journal	Published Date	Author	Title
10753940	J. Biol. Chem.	2000	Kawamoto Y et al.	Cyclopentenone prostaglandins as potential inducers of phase II detoxification enzymes. 15-deoxy-delta(12,14)-prostaglandin j2-induced expression of glutathione S-transferases.
19429785	Development	2009	Moniot B et al.	The PGD2 pathway, independently of FGF9, amplifies SOX9 activity in Sertoli cells during male sexual differentiation.
20231490	Proc. Natl. Acad. Sci. U.S.A.	2010	Koharudin LM et al.	Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1.
15889150	EMBO J.	2005	Malki S et al.	Prostaglandin D2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation.
16737963	J. Biol. Chem.	2006	Wang Z et al.	Prostaglandin J2 alters pro-survival and pro-death gene expression patterns and 26 S proteasome assembly in human neuroblastoma cells.
18579528	J. Biol. Chem.	2008	Amir-Moazami O et al.	Phospholipid scramblase 1 modulates a selected set of IgE receptor-mediated mast cell responses through LAT-dependent pathway.
26941195	Plant Physiol.	2016	Hölscher C et al.	Defects in Peroxisomal 6-Phosphogluconate Dehydrogenase Isoform PGD2 Prevent Gametophytic Interaction in Arabidopsis thaliana.
26801686	Biochem. Pharmacol.	2016	Koyani CN et al.	Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ2-mediated cell death.
26777630	Biochim. Biophys. Acta	2016	Shirley D et al.	Resveratrol preferentially inhibits IgE-dependent PGD2 biosynthesis but enhances TNF production from human skin mast cells.
26032638	Biochem. Pharmacol.	2015	Cossette C et al.	Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes.
25269616	Reproduction	2015	Rossitto M et al.	Multiple roles of the prostaglandin D2 signaling pathway in reproduction.
25159329	Am. J. Physiol. Endocrinol. Metab.	2014	Cantley JL et al.	Targeting steroid receptor coactivator 1 with antisense oligonucleotides increases insulin-stimulated skeletal muscle glucose uptake in chow-fed and high-fat-fed male rats.
24698234	Int. J. Cardiol.	2014	Koyani CN et al.	15-deoxy-Δ¹²,¹⁴-PGJ₂ promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis.