20-HETE

20-hete is a lipid of Fatty Acyls (FA) class. 20-hete is associated with abnormalities such as Cyst, Kidney Diseases, Kidney Failure, Chronic, Cystic Kidney Diseases and Simple renal cyst. The involved functions are known as Phosphorylation, inhibitors, Hypertrophy, Epithelial Cell Proliferation and Anabolism. 20-hete often locates in Mouse Kidney, Microsomes, Tissue membrane, Body tissue and Cytoplasmic matrix. The associated genes with 20-HETE are CYP4F3 gene, PKHD1 gene, Transgenes, P4HTM gene and CYP2E1 gene. The related lipids are Promega, enterodiol, Fatty Acids, hexanoic acid and U 73343. The related experimental models are Mouse Model, Knock-out, Streptozotocin Diabetes, Transgenic Model and Rodent Model.

References related to genes published in Others

PMID	Journal	Published Date	Author	Title
9575802	Am. J. Physiol.	1998	Amlal H et al.	ANG II controls Na(+)-K+(NH4+)-2Cl- cotransport via 20-HETE and PKC in medullary thick ascending limb.
9770549	Proc. Natl. Acad. Sci. U.S.A.	1998	Muthalif MM et al.	20-Hydroxyeicosatetraenoic acid mediates calcium/calmodulin-dependent protein kinase II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells.
9729509	Am. J. Physiol.	1998	Alonso-Galicia M et al.	Contribution of 20-HETE to the vasodilator actions of nitric oxide in renal arteries.
9688677	Am. J. Physiol.	1998	Su P et al.	Inhibition of renal arachidonic acid omega-hydroxylase activity with ABT reduces blood pressure in the SHR.
10070137	Am. J. Physiol.	1999	Oyekan AO et al.	Endothelin-1 and CYP450 arachidonate metabolites interact to promote tissue injury in DOCA-salt hypertension.
10484476	Am. J. Physiol.	1999	McGiff JC and Quilley J	20-HETE and the kidney: resolution of old problems and new beginnings.
9950955	Am. J. Physiol.	1999	Wang MH et al.	Contribution of cytochrome P-450 4A1 and 4A2 to vascular 20-hydroxyeicosatetraenoic acid synthesis in rat kidneys.
11739122	Am. J. Physiol. Renal Physiol.	2002	Escalante BA et al.	Role of cytochrome P-450 arachidonate metabolites in endothelin signaling in rat proximal tubule.
11208597	Am. J. Physiol. Renal Physiol.	2001	Gu R et al.	Role of 20-HETE in mediating the effect of dietary K intake on the apical K channels in the mTAL.
12070222	J. Appl. Physiol.	2002	Zhu D et al.	CYP4A mRNA, protein, and product in rat lungs: novel localization in vascular endothelium.
12060587	Am. J. Physiol. Renal Physiol.	2002	Marji JS et al.	Cytochrome P-450 4A isoform expression and 20-HETE synthesis in renal preglomerular arteries.
12235040	J. Appl. Physiol.	2002	Yu M et al.	Nitric oxide contributes to 20-HETE-induced relaxation of pulmonary arteries.
12794071	J. Biol. Chem.	2003	Basora N et al.	20-hydroxyeicosatetraenoic acid (20-HETE) activates mouse TRPC6 channels expressed in HEK293 cells.
12684227	Am. J. Physiol. Renal Physiol.	2003	Wang MH et al.	Regulation of renal CYP4A expression and 20-HETE synthesis by nitric oxide in pregnant rats.
12754190	Am. J. Physiol. Lung Cell Mol. Physiol.	2003	Cloutier M et al.	20-HETE inotropic effects involve the activation of a nonselective cationic current in airway smooth muscle.
12566369	Circulation	2003	Laffer CL et al.	Differential regulation of natriuresis by 20-hydroxyeicosatetraenoic Acid in human salt-sensitive versus salt-resistant hypertension.
10992547	Thorax	2000	Carroll MA and McGiff JC	A new class of lipid mediators: cytochrome P450 arachidonate metabolites.
10884363	Circ. Res.	2000	Kaley G	Regulation of vascular tone: role of 20-HETE in the modulation of myogenic reactivity.
9618440	J. Pharmacol. Exp. Ther.	1998	Powell PK et al.	Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11.
14634044	J. Pharmacol. Exp. Ther.	2004	Xu F et al.	Catalytic activity and isoform-specific inhibition of rat cytochrome p450 4F enzymes.
15075246	Am. J. Physiol. Lung Cell Mol. Physiol.	2004	Fuloria M et al.	20-hydroxyeicosatetraenoic acid is a vasoconstrictor in the newborn piglet pulmonary microcirculation.
21527533	J. Pharmacol. Exp. Ther.	2011	Guo AM et al.	The cytochrome P450 4A/F-20-hydroxyeicosatetraenoic acid system: a regulator of endothelial precursor cells derived from human umbilical cord blood.
20861217	J. Nutr.	2010	Bardowell SA et al.	Common variants of cytochrome P450 4F2 exhibit altered vitamin E-{omega}-hydroxylase specific activity.
21617146	Stroke	2011	Crago EA et al.	Cerebrospinal fluid 20-HETE is associated with delayed cerebral ischemia and poor outcomes after aneurysmal subarachnoid hemorrhage.
18842817	Am. J. Physiol. Renal Physiol.	2008	Williams JM et al.	Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury.
19443836	Circ. Res.	2009	Inoue R et al.	Synergistic activation of vascular TRPC6 channel by receptor and mechanical stimulation via phospholipase C/diacylglycerol and phospholipase A2/omega-hydroxylase/20-HETE pathways.
19570883	Am. J. Physiol. Renal Physiol.	2009	Akbulut T et al.	20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
19675180	Am. J. Physiol. Renal Physiol.	2009	Inoue K et al.	Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE.
19841472	J. Pharmacol. Exp. Ther.	2010	Cheng J et al.	20-hydroxy-5,8,11,14-eicosatetraenoic acid mediates endothelial dysfunction via IkappaB kinase-dependent endothelial nitric-oxide synthase uncoupling.
19846914	Anticancer Res.	2009	Alexanian A et al.	Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth.
20061439	Am. J. Physiol. Lung Cell Mol. Physiol.	2010	Bodiga S et al.	20-HETE-induced nitric oxide production in pulmonary artery endothelial cells is mediated by NADPH oxidase, H2O2, and PI3-kinase/Akt.
17660330	Am. J. Physiol. Lung Cell Mol. Physiol.	2007	Morin C et al.	Functional effects of 20-HETE on human bronchi: hyperpolarization and relaxation due to BKCa channel activation.
18171997	Am. J. Physiol. Renal Physiol.	2008	Nilakantan V et al.	20-HETE-mediated cytotoxicity and apoptosis in ischemic kidney epithelial cells.
18235092	J. Am. Soc. Nephrol.	2008	Liu H et al.	Association of a functional cytochrome P450 4F2 haplotype with urinary 20-HETE and hypertension.
15831442	J. Pharmacol. Exp. Ther.	2005	Miyata N et al.	Beneficial effects of a new 20-hydroxyeicosatetraenoic acid synthesis inhibitor, TS-011 [N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamide], on hemorrhagic and ischemic stroke.
16396943	Am. J. Physiol. Renal Physiol.	2006	Roman RJ et al.	Characterization of blood pressure and renal function in chromosome 5 congenic strains of Dahl S rats.
15499026	Circ. Res.	2004	Scotland RS et al.	Vanilloid receptor TRPV1, sensory C-fibers, and vascular autoregulation: a novel mechanism involved in myogenic constriction.
16081420	J. Biol. Chem.	2005	Collins XH et al.	Omega-oxidation of 20-hydroxyeicosatetraenoic acid (20-HETE) in cerebral microvascular smooth muscle and endothelium by alcohol dehydrogenase 4.
16081682	J. Pharmacol. Exp. Ther.	2005	Guo M et al.	Human U251 glioma cell proliferation is suppressed by HET0016 [N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine], a selective inhibitor of CYP4A.
16055480	Am. J. Physiol. Lung Cell Mol. Physiol.	2005	Yaghi A and Sims SM	Constrictor-induced translocation of NFAT3 in human and rat pulmonary artery smooth muscle.
15998843	Am. J. Physiol. Renal Physiol.	2005	Huang H et al.	Renal 20-HETE inhibition attenuates changes in renal hemodynamics induced by L-NAME treatment in pregnant rats.
16543501	Circ. Res.	2006	Wang JS et al.	Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus.
16614311	Circ. Res.	2006	Harder DR and Roman RJ	Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus.
16679377	Am. J. Physiol. Lung Cell Mol. Physiol.	2006	Chen Y et al.	Mechanisms of activation of eNOS by 20-HETE and VEGF in bovine pulmonary artery endothelial cells.
16679379	Am. J. Physiol. Lung Cell Mol. Physiol.	2006	Jacobs ER et al.	VEGF-induced relaxation of pulmonary arteries is mediated by endothelial cytochrome P-450 hydroxylase.
17210799	J. Pharmacol. Exp. Ther.	2007	Guo AM et al.	Activation of vascular endothelial growth factor through reactive oxygen species mediates 20-hydroxyeicosatetraenoic acid-induced endothelial cell proliferation.
18596124	J. Am. Soc. Nephrol.	2008	Park F et al.	20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease.
18591218	J. Pharmacol. Exp. Ther.	2008	Guo AM et al.	Expression of CYP4A1 in U251 human glioma cell induces hyperproliferative phenotype in vitro and rapidly growing tumors in vivo.
18725506	Drug Metab. Dispos.	2008	Mu Y et al.	Intravenous formulation of N-hydroxy-N'-(4-n-butyl-2-methylphenyl)formamidine (HET0016) for inhibition of rat brain 20-hydroxyeicosatetraenoic acid formation.
22723444	Arterioscler. Thromb. Vasc. Biol.	2012	Cheng J et al.	Induction of angiotensin-converting enzyme and activation of the renin-angiotensin system contribute to 20-hydroxyeicosatetraenoic acid-mediated endothelial dysfunction.
22798501	Cancer Genomics Proteomics	2012 Jul-Aug	Alexanian A et al.	20-HETE-producing enzymes are up-regulated in human cancers.
23641057	J. Am. Soc. Nephrol.	2013	Wu CC et al.	Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase.
23658377	J. Pharmacol. Exp. Ther.	2013	Orozco LD et al.	20-Hydroxyeicosatetraenoic acid inhibition attenuates balloon injury-induced neointima formation and vascular remodeling in rat carotid arteries.
23392684	J. Neurosci.	2013	Fordsmann JC et al.	Increased 20-HETE synthesis explains reduced cerebral blood flow but not impaired neurovascular coupling after cortical spreading depression in rat cerebral cortex.
23966667	J. Lipid Res.	2013	Van Bogaert I et al.	Preparation of 20-HETE using multifunctional enzyme type 2-negative Starmerella bombicola.
25792716	J. Appl. Physiol.	2015	Liu X et al.	Contribution of epoxyeicosatrienoic acids to the cerebral blood flow response to hypoxemia.
25526688	Prostaglandins Other Lipid Mediat.	2015 Jan-Mar	Garcia V et al.	Androgen-induced hypertension in angiotensinogen deficient mice: role of 20-HETE and EETS.
27559173	J. Neurosci.	2016	Ziegler N et al.	β-Catenin Is Required for Endothelial Cyp1b1 Regulation Influencing Metabolic Barrier Function.
27528620	Mol. Cell. Biol.	2016	Garbacz WG et al.	Hepatic Overexpression of CD36 Improves Glycogen Homeostasis and Attenuates High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance.
27084395	Vascul. Pharmacol.	2016	Chen L et al.	20-HETE contributes to ischemia-induced angiogenesis.
26747234	Prostaglandins Other Lipid Mediat.	2016	Huang H et al.	Cyclooxygenase- and cytochrome P450-derived eicosanoids in stroke.
26699146	J. Pharmacol. Exp. Ther.	2016	Garcia V et al.	20-HETE Activates the Transcription of Angiotensin-Converting Enzyme via Nuclear Factor-κB Translocation and Promoter Binding.
26033621	Drug Metab. Dispos.	2015	Althurwi HN et al.	Early Changes in Cytochrome P450s and Their Associated Arachidonic Acid Metabolites Play a Crucial Role in the Initiation of Cardiac Hypertrophy Induced by Isoproterenol.
25813407	Prostaglandins Other Lipid Mediat.	2015	Hoopes SL et al.	Vascular actions of 20-HETE.
25644108	J. Am. Soc. Nephrol.	2015	Muroya Y et al.	Deficiency in the Formation of 20-Hydroxyeicosatetraenoic Acid Enhances Renal Ischemia-Reperfusion Injury.
25447342	Prostaglandins Other Lipid Mediat.	2015 Jan-Mar	McCarthy ET et al.	Ethanol at low concentrations protects glomerular podocytes through alcohol dehydrogenase and 20-HETE.
25249502	J. Lipid Res.	2014	Jarrar YB et al.	Determination of major UDP-glucuronosyltransferase enzymes and their genotypes responsible for 20-HETE glucuronidation.