rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

References related to genes published in Others

PMID	Journal	Published Date	Author	Title
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11390614	J. Virol.	2001	Noya F et al.	p21cip1 Degradation in differentiated keratinocytes is abrogated by costabilization with cyclin E induced by human papillomavirus E7.
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12117979	Infect. Immun.	2002	Wadsworth SJ and Goldfine H	Mobilization of protein kinase C in macrophages induced by Listeria monocytogenes affects its internalization and escape from the phagosome.
11943682	Am. J. Physiol. Lung Cell Mol. Physiol.	2002	Liedtke CM et al.	Modulation of Na-K-2Cl cotransport by intracellular Cl(-) and protein kinase C-delta in Calu-3 cells.
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12941843	Cancer Res.	2003	Tillman DM et al.	Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C.
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15276481	Cardiovasc. Res.	2004	Schreckenberg R et al.	Inhibition of Ca2+-dependent PKC isoforms unmasks ERK-dependent hypertrophic growth evoked by phenylephrine in adult ventricular cardiomyocytes.
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21191110	Biol. Reprod.	2011	Yang QE et al.	Protein kinase C delta mediates fibroblast growth factor-2-induced interferon-tau expression in bovine trophoblast.
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19762431	Am. J. Physiol. Gastrointest. Liver Physiol.	2010	Ohno I et al.	Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.
19037087	Carcinogenesis	2009	Lim JH et al.	Rottlerin induces apoptosis via death receptor 5 (DR5) upregulation through CHOP-dependent and PKC delta-independent mechanism in human malignant tumor cells.
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15342779	Mol. Biol. Cell	2004	Lladó A et al.	Protein kinaseCdelta-calmodulin crosstalk regulates epidermal growth factor receptor exit from early endosomes.
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17565007	J. Pharmacol. Exp. Ther.	2007	Zhang D et al.	Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.
18083882	Appl. Environ. Microbiol.	2008	Shivshankar P et al.	Rottlerin inhibits chlamydial intracellular growth and blocks chlamydial acquisition of sphingolipids from host cells.
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15817518	Brain	2005	Obreja O et al.	Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons.
15574884	Mol. Biol. Cell	2005	Wiedłocha A et al.	Phosphorylation-regulated nucleocytoplasmic trafficking of internalized fibroblast growth factor-1.
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15489375	Am. J. Physiol. Lung Cell Mol. Physiol.	2005	Woo CH et al.	VCAM-1 upregulation via PKCdelta-p38 kinase-linked cascade mediates the TNF-alpha-induced leukocyte adhesion and emigration in the lung airway epithelium.
16040631	Am. J. Physiol. Lung Cell Mol. Physiol.	2005	Brown JM et al.	Effects of rottlerin on silica-exacerbated systemic autoimmune disease in New Zealand mixed mice.
15899849	Mol. Cell. Biol.	2005	Roose JP et al.	A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells.
15949478	Cardiovasc. Res.	2005	Skaletz-Rorowski A et al.	PKC delta-induced activation of MAPK pathway is required for bFGF-stimulated proliferation of coronary smooth muscle cells.
16959960	J. Pharmacol. Exp. Ther.	2006	Jane EP et al.	Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells.
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16571779	FASEB J.	2006	Shukla A et al.	Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCdelta-dependent pathway in murine lung.
17077164	J. Leukoc. Biol.	2007	Grybko MJ et al.	Protein kinase C activity is required for cytotoxic T cell lytic granule exocytosis, but the theta isoform does not play a preferential role.
16614259	J. Leukoc. Biol.	2006	Cronshaw DG et al.	Evidence that phospholipase-C-dependent, calcium-independent mechanisms are required for directional migration of T-lymphocytes in response to the CCR4 ligands CCL17 and CCL22.
21990324	Endocr. Relat. Cancer	2011	Chen Z et al.	Protein kinase Cδ inactivation inhibits cellular proliferation and decreases survival in human neuroendocrine tumors.
23995289	FASEB J.	2013	Goldklang MP et al.	Treatment of experimental asthma using a single small molecule with anti-inflammatory and BK channel-activating properties.
24449838	Development	2014	Hagelkruys A et al.	A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog.
24607787	Cell. Signal.	2014	Lu W et al.	Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.