Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
References related to genes published in Others
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 10642557 | Biol. Reprod. | 2000 | Dabrowski K et al. | Effects of diets containing gossypol on reproductive capacity of rainbow trout (Oncorhynchus mykiss). |
| 10829068 | Proc. Natl. Acad. Sci. U.S.A. | 2000 | Heiser V et al. | Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy. |
| 19228717 | Clin. Cancer Res. | 2009 | Kang MH and Reynolds CP | Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. |
| 19528479 | Anticancer Res. | 2009 | Huang YW et al. | (-)-Gossypol reduces invasiveness in metastatic prostate cancer cells. |
| 20587533 | Mol. Cancer Res. | 2010 | Voss V et al. | The pan-Bcl-2 inhibitor (-)-gossypol triggers autophagic cell death in malignant glioma. |
| 20133848 | Proc. Natl. Acad. Sci. U.S.A. | 2010 | Le A et al. | Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. |
| 21357440 | Mol. Cancer Res. | 2011 | Amm HM et al. | Mechanisms of drug sensitization to TRA-8, an agonistic death receptor 5 antibody, involve modulation of the intrinsic apoptotic pathway in human breast cancer cells. |
| 15570010 | Clin. Cancer Res. | 2004 | Oliver CL et al. | In vitro effects of the BH3 mimetic, (-)-gossypol, on head and neck squamous cell carcinoma cells. |
| 15621416 | FEMS Microbiol. Lett. | 2005 | Weissenmayer B et al. | The calcineurin inhibitor gossypol impairs growth, cell signalling and development in Dictyostelium discoideum. |
| 15849309 | Plant Physiol. | 2005 | Townsend BJ et al. | Antisense suppression of a (+)-delta-cadinene synthase gene in cotton prevents the induction of this defense response gene during bacterial blight infection but not its constitutive expression. |
| 16935937 | FASEB J. | 2006 | Lei X et al. | Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2. |
| 17110445 | Proc. Natl. Acad. Sci. U.S.A. | 2006 | Sunilkumar G et al. | Engineering cottonseed for use in human nutrition by tissue-specific reduction of toxic gossypol. |
| 22525702 | Cancer Res. | 2012 | Mazumder S et al. | Mcl-1 Phosphorylation defines ABT-737 resistance that can be overcome by increased NOXA expression in leukemic B cells. |
| 22466256 | Mol. Cancer Res. | 2012 | Billard C | Development of Noxa-like BH3 mimetics for apoptosis-based therapeutic strategy in chronic lymphocytic leukemia. |
| 22158856 | Cancer Res. | 2012 | Imai A et al. | Metronomic dosing of BH3 mimetic small molecule yields robust antiangiogenic and antitumor effects. |