lanosterol

lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.

References related to genes published in Others


PMIDJournalPublished DateAuthorTitle
9326581Proc. Natl. Acad. Sci. U.S.A.1997Gachotte D et al.A yeast sterol auxotroph (erg25) is rescued by addition of azole antifungals and reduced levels of heme.
9874778Proc. Natl. Acad. Sci. U.S.A.1999Kaneshiro ES et al.Pneumocysterol [(24Z)-ethylidenelanost-8-en-3beta-ol], a rare sterol detected in the opportunistic pathogen Pneumocystis carinii hominis: structural identity and chemical synthesis.
10535978Proc. Natl. Acad. Sci. U.S.A.1999Gachotte D et al.Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation.
21252064Arterioscler. Thromb. Vasc. Biol.2011Burkhardt R et al.Cosegregation of aortic root atherosclerosis and intermediate lipid phenotypes on chromosomes 2 and 8 in an intercross of C57BL/6 and BALBc/ByJ low-density lipoprotein receptor-/- mice.
21169436Appl. Environ. Microbiol.2011Parker JE et al.Mechanism of binding of prothioconazole to Mycosphaerella graminicola CYP51 differs from that of other azole antifungals.
19139393Proc. Natl. Acad. Sci. U.S.A.2009Ohyama K et al.Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.
22355128Proc. Natl. Acad. Sci. U.S.A.2012Kořený L et al.Aerobic kinetoplastid flagellate Phytomonas does not require heme for viability.
20421456Plant Physiol.2010Carland F et al.The sterol methyltransferases SMT1, SMT2, and SMT3 influence Arabidopsis development through nonbrassinosteroid products.
18364712Mol. Syst. Biol.2008Andersen MR et al.Metabolic model integration of the bibliome, genome, metabolome and reactome of Aspergillus niger.
21831043Biochem. J.2011Cabrito TR et al.The yeast ABC transporter Pdr18 (ORF YNR070w) controls plasma membrane sterol composition, playing a role in multidrug resistance.
20531405Mol. Syst. Biol.2010Owens CM et al.Chemical combinations elucidate pathway interactions and regulation relevant to Hepatitis C replication.
20443782Clin. Sci.2010Jarvie E et al.Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring.
19897737Eukaryotic Cell2010Joffrion TM et al.Functional characterization and localization of Pneumocystis carinii lanosterol synthase.
17951521Eukaryotic Cell2007Oliver BG et al.cis-Acting elements within the Candida albicans ERG11 promoter mediate the azole response through transcription factor Upc2p.
16989930Toxicology2006Trösken ER et al.Comparison of lanosterol-14 alpha-demethylase (CYP51) of human and Candida albicans for inhibition by different antifungal azoles.
25746994Appl. Environ. Microbiol.2015Price CL et al.Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase.