25-Hydroxycholesterol

25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.

References related to genes published in Others


PMIDJournalPublished DateAuthorTitle
9081687Arterioscler. Thromb. Vasc. Biol.1997Liu Y et al.Macrophages isolated from human atherosclerotic plaques produce IL-8, and oxysterols may have a regulatory function for IL-8 production.
11967195Biol. Reprod.2002Chen JJ et al.25-hydroxycholesterol is produced by testicular macrophages during the early postnatal period and influences differentiation of Leydig cells in vitro.
14709622Drug Metab. Dispos.2004Shenoy SD et al.CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor.
21123296J. Leukoc. Biol.2010McDonald JG and Russell DWEditorial: 25-Hydroxycholesterol: a new life in immunology.
18854425Am. J. Physiol. Endocrinol. Metab.2008Ma Y et al.25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway.
15604201Am. J. Physiol. Gastrointest. Liver Physiol.2005Alrefai WA et al.Cholesterol modulates human intestinal sodium-dependent bile acid transporter.
16611739Am. J. Physiol., Cell Physiol.2006Tam SP et al.ABCA1 mediates high-affinity uptake of 25-hydroxycholesterol by membrane vesicles and rapid efflux of oxysterol by intact cells.
21979142Cardiovasc. Res.2012Wang F et al.Interferon regulator factor 1/retinoic inducible gene I (IRF1/RIG-I) axis mediates 25-hydroxycholesterol-induced interleukin-8 production in atherosclerosis.
22238372Mol. Hum. Reprod.2012Aye IL et al.Oxysterols exert proinflammatory effects in placental trophoblasts via TLR4-dependent, cholesterol-sensitive activation of NF-κB.
23729662Cardiovasc. Res.2013Appukuttan A et al.Oxysterol-induced apoptosis of smooth muscle cells is under the control of a soluble adenylyl cyclase.
25104388Science2014Reboldi A et al.Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon.
24302009Am. J. Physiol. Endocrinol. Metab.2014Ren S and Ning YSulfation of 25-hydroxycholesterol regulates lipid metabolism, inflammatory responses, and cell proliferation.
20227267Prostaglandins Leukot. Essent. Fatty Acids2010 Apr-JunVallim T and Salter AMRegulation of hepatic gene expression by saturated fatty acids.
22225954Metab. Clin. Exp.2012Bai Q et al.Oxysterol sulfation by cytosolic sulfotransferase suppresses liver X receptor/sterol regulatory element binding protein-1c signaling pathway and reduces serum and hepatic lipids in mouse models of nonalcoholic fatty liver disease.
20491656Clin. Sci.2010Borthwick F et al.Overexpression of STARD3 in human monocyte/macrophages induces an anti-atherogenic lipid phenotype.
28161398EBioMedicine2017Shen C et al.Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3β Signaling Pathway.
27155346J. Steroid Biochem. Mol. Biol.2017Bah SY et al.Immune oxysterols: Role in mycobacterial infection and inflammation.
26160948Science2015Ren R et al.PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels.
25903345J. Virol.2015Xiang Y et al.Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection.