Tetradecanoic acid

Tetradecanoic acid is a lipid of Fatty Acyls (FA) class. Tetradecanoic acid is associated with abnormalities such as Chronic lung disease, Infection, Spastic syndrome, Diabetes and Cardiovascular Diseases. The involved functions are known as Fatty acid biosynthetic process, Anabolism, lung alveolus development, 5-(carboxyamino)imidazole ribonucleotide mutase activity and Homeostasis. Tetradecanoic acid often locates in Structure of parenchyma of lung, Blood, Head, Membrane and Cytoplasmic matrix. The associated genes with Tetradecanoic acid are SLC33A1 gene, SFTPA1 gene, P4HTM gene, Polypeptides and GPR132 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, palmitoleic acid, Phosphatidylglycerols and Butanols.

References related to genes published in Others

PMID	Journal	Published Date	Author	Title
9436987	Mol. Biol. Cell	1998	Morales J et al.	Plasma membrane localization of G alpha z requires two signals.
9103475	J. Pharmacol. Exp. Ther.	1997	Naze S et al.	Activation of phospholipase D by endothelin-1 in rat myometrium. Role of calcium and protein kinase C.
10205160	EMBO J.	1999	Godsel LM and Engman DM	Flagellar protein localization mediated by a calcium-myristoyl/palmitoyl switch mechanism.
9611229	Nucleic Acids Res.	1998	Cok SJ et al.	Transcription of INO2 and INO4 is regulated by the state of protein N-myristoylation in Saccharomyces cerevisiae.
12118067	J. Cell. Sci.	2002	Navarro-Lérida I et al.	Distance-dependent cellular palmitoylation of de-novo-designed sequences and their translocation to plasma membrane subdomains.
12414990	J. Cell. Sci.	2002	Lin CY et al.	A developmentally regulated ARF-like 5 protein (ARL5), localized to nuclei and nucleoli, interacts with heterochromatin protein 1.
12829627	Diabetes	2003	Mittendorfer B et al.	What does the measurement of whole-body fatty acid rate of appearance in plasma by using a fatty acid tracer really mean?
12455958	Eukaryotic Cell	2002	Shaw BD et al.	Aspergillus nidulans swoF encodes an N-myristoyl transferase.
12372805	Am. J. Physiol., Cell Physiol.	2002	Clarke AL et al.	Modulation of BK(Ca) channel activity by fatty acids: structural requirements and mechanism of action.
10779329	Mol. Cell. Biol.	2000	Manes G et al.	Slap negatively regulates Src mitogenic function but does not revert Src-induced cell morphology changes.
11006339	Plant Cell	2000	Ishitani M et al.	SOS3 function in plant salt tolerance requires N-myristoylation and calcium binding.
15302818	Eukaryotic Cell	2004	Paul KS et al.	Multiple triclosan targets in Trypanosoma brucei.
15126327	Cancer Res.	2004	Uno F et al.	Myristoylation of the fus1 protein is required for tumor suppression in human lung cancer cells.
21636561	J. Appl. Physiol.	2011	Bernhard W et al.	Increased palmitoyl-myristoyl-phosphatidylcholine in neonatal rat surfactant is lung specific and correlates with oral myristic acid supply.
19661213	Drug Metab. Dispos.	2009	Nakano M et al.	Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase.
20584982	Mol. Cell. Biol.	2010	Patwardhan P and Resh MD	Myristoylation and membrane binding regulate c-Src stability and kinase activity.
17616681	Cancer Res.	2007	Adam RM et al.	Cholesterol sensitivity of endogenous and myristoylated Akt.
15687105	J. Cell. Sci.	2005	Price HP et al.	Functional analysis of TbARL1, an N-myristoylated Golgi protein essential for viability in bloodstream trypanosomes.
16569659	J. Cell. Sci.	2006	Navarro-Lérida I et al.	N-terminal palmitoylation within the appropriate amino acid environment conveys on NOS2 the ability to progress along the intracellular sorting pathways.
21965604	FASEB J.	2012	Martin DD et al.	Tandem reporter assay for myristoylated proteins post-translationally (TRAMPP) identifies novel substrates for post-translational myristoylation: PKCε, a case study.
22391103	Mol. Pharmacol.	2012	Puhl AC et al.	Mode of peroxisome proliferator-activated receptor γ activation by luteolin.
22000011	Cell	2011	Grebien F et al.	Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis.
20841452	Plant Physiol.	2010	Do PT et al.	The influence of fruit load on the tomato pericarp metabolome in a Solanum chmielewskii introgression line population.
20534735	Plant Physiol.	2010	Brechenmacher L et al.	Soybean metabolites regulated in root hairs in response to the symbiotic bacterium Bradyrhizobium japonicum.
19934003	Diabetes	2010	Yeop Han C et al.	Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes: dissociation of adipocyte hypertrophy from inflammation.
18398033	Cancer Epidemiol. Biomarkers Prev.	2008	Kurahashi N et al.	Dairy product, saturated fatty acid, and calcium intake and prostate cancer in a prospective cohort of Japanese men.
18068687	Biochem. Pharmacol.	2008	Isenberg JS et al.	Differential effects of ABT-510 and a CD36-binding peptide derived from the type 1 repeats of thrombospondin-1 on fatty acid uptake, nitric oxide signaling, and caspase activation in vascular cells.
17932026	FASEB J.	2008	Martin DD et al.	Rapid detection, discovery, and identification of post-translationally myristoylated proteins during apoptosis using a bio-orthogonal azidomyristate analog.
14724220	J. Pharmacol. Exp. Ther.	2004	French KJ et al.	Cyclohexyl-octahydro-pyrrolo[1,2-a]pyrazine-based inhibitors of human N-myristoyltransferase-1.
28137759	J. Cell. Sci.	2017	Demetriadou A et al.	Mouse Stbd1 is N-myristoylated and affects ER-mitochondria association and mitochondrial morphology.
26621918	J. Lipid Res.	2016	Soupene E et al.	Association of NMT2 with the acyl-CoA carrier ACBD6 protects the N-myristoyltransferase reaction from palmitoyl-CoA.
26584780	Chem. Biol.	2015	Charlton TM et al.	Quantitative Lipoproteomics in Clostridium difficile Reveals a Role for Lipoproteins in Sporulation.
26244740	Biophys. J.	2015	Scheidt HA et al.	Structural Thermodynamics of myr-Src(2-19) Binding to Phospholipid Membranes.