Cholic acid
Cholic acid is a lipid of Sterol Lipids (ST) class. Cholic acid is associated with abnormalities such as Cholestasis, Intrahepatic Cholestasis, Atherosclerosis, Diabetes and cholesterol gallstones. The involved functions are known as Homeostasis, Enterohepatic Circulation, Proliferation (morphologic abnormality), Process and Cell Proliferation. Cholic acid often locates in Hepatic, Cytoplasmic matrix, Membrane, Protoplasm and Tissue membrane. The associated genes with Cholic acid are CYP27A1 gene, ABCB11 gene, NR5A2 gene, SLC10A2 gene and SLC10A1 gene. The related lipids are ursocholic acid, Steroids, Cholestenes, Cholestanes and cholanic acid.
References related to genes published in Others
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 10446117 | Gut | 1999 | Rodrigues CM et al. | Bile acid patterns in meconium are influenced by cholestasis of pregnancy and not altered by ursodeoxycholic acid treatment. |
| 12970144 | Gut | 2003 | Lemonde HA et al. | Mutations in SRD5B1 (AKR1D1), the gene encoding delta(4)-3-oxosteroid 5beta-reductase, in hepatitis and liver failure in infancy. |
| 11053402 | J. Bacteriol. | 2000 | Kurdi P et al. | Cholic acid is accumulated spontaneously, driven by membrane deltapH, in many lactobacilli. |
| 21518881 | Proc. Natl. Acad. Sci. U.S.A. | 2011 | Siggs OM et al. | X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C. |
| 19417011 | Physiol. Genomics | 2009 | Bochkis IM et al. | Foxa2-dependent hepatic gene regulatory networks depend on physiological state. |
| 17686960 | Am. J. Physiol. Renal Physiol. | 2007 | Bang CA et al. | Effect of uremia on HDL composition, vascular inflammation, and atherosclerosis in wild-type mice. |
| 18334542 | J. Leukoc. Biol. | 2008 | Desai MS et al. | Atherogenic diet-induced hepatitis is partially dependent on murine TLR4. |
| 18292224 | Proc. Natl. Acad. Sci. U.S.A. | 2008 | Rao A et al. | The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis. |
| 15466244 | J. Pharmacol. Exp. Ther. | 2005 | Miyata M et al. | Role of farnesoid X receptor in the enhancement of canalicular bile acid output and excretion of unconjugated bile acids: a mechanism for protection against cholic acid-induced liver toxicity. |
| 18539741 | J. Bacteriol. | 2008 | Horinouchi M et al. | Identification of genes involved in inversion of stereochemistry of a C-12 hydroxyl group in the catabolism of cholic acid by Comamonas testosteroni TA441. |
| 18583509 | Drug Metab. Dispos. | 2008 | Deo AK and Bandiera SM | Identification of human hepatic cytochrome p450 enzymes involved in the biotransformation of cholic and chenodeoxycholic acid. |
| 24085190 | Toxicol. Sci. | 2014 | Luo L et al. | Evaluation of serum bile acid profiles as biomarkers of liver injury in rodents. |
| 22454486 | J. Nucl. Med. | 2012 | Frisch K et al. | [N-methyl-11C]cholylsarcosine, a novel bile acid tracer for PET/CT of hepatic excretory function: radiosynthesis and proof-of-concept studies in pigs. |
| 22096226 | Mol. Pharmacol. | 2012 | Blazquez AG et al. | Characterization of the role of ABCG2 as a bile acid transporter in liver and placenta. |
| 15967843 | Circulation | 2005 | Zhang S et al. | Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice. |
| 11802798 | Biochem. J. | 2002 | Müller O et al. | Expression of liver plasma membrane transporters in gallstone-susceptible and gallstone-resistant mice. |
| 25477283 | FASEB J. | 2015 | Shih DM et al. | PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis. |
| 25338812 | Diabetes | 2015 | Kaur A et al. | Loss of Cyp8b1 improves glucose homeostasis by increasing GLP-1. |