lysophosphatidic acid

lysophosphatidic acid is a lipid of Glycerophospholipids (GP) class. Lysophosphatidic acid is associated with abnormalities such as Atherosclerosis, Alzheimer's Disease, Asthma, Diabetes Mellitus, Non-Insulin-Dependent and Septicemia. The involved functions are known as Inflammation, Chemotaxis, Binding (Molecular Function), Polymerization and Inflammatory Response. Lysophosphatidic acid often locates in Cytoskeleton, Microfilaments, actin cytoskeleton, Extracellular and Structure of germinal center of lymph node. The associated genes with lysophosphatidic acid are TNF gene, MAPK3 gene, RHOA gene, CDC42 gene and ADRBK1 gene. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Lysophosphatidylcholines, Lysophospholipids and Phosphatidic Acid. The related experimental models are Knock-out, Transgenic Model, Rodent Model and Disease model.

References related to genes published in Others

PMID	Journal	Published Date	Author	Title
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27641493	Neuron	2016	Cheng J et al.	Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling.
27474750	J. Pharmacol. Exp. Ther.	2016	Hopkins MM et al.	Positive and Negative Cross-Talk between Lysophosphatidic Acid Receptor 1, Free Fatty Acid Receptor 4, and Epidermal Growth Factor Receptor in Human Prostate Cancer Cells.
27453502	Dev. Cell	2016	Liu X et al.	PRG-1 Regulates Synaptic Plasticity via Intracellular PP2A/β1-Integrin Signaling.
27401461	Physiol Rep	2016	Sweat RS et al.	Lysophosphatidic acid does not cause blood/lymphatic vessel plasticity in the rat mesentery culture model.
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26947063	Cell Rep	2016	Qin H et al.	YAP Induces Human Naive Pluripotency.
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26597701	Biochim. Biophys. Acta	2016	Nan L et al.	Cross-talk between lysophosphatidic acid receptor 1 and tropomyosin receptor kinase A promotes lung epithelial cell migration.
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25683913	Cell. Signal.	2015	Guo L et al.	Krüppel-like factor 5 incorporates into the β-catenin/TCF complex in response to LPA in colon cancer cells.
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25578862	Cell. Signal.	2015	Wallert MA et al.	RhoA Kinase (Rock) and p90 Ribosomal S6 Kinase (p90Rsk) phosphorylation of the sodium hydrogen exchanger (NHE1) is required for lysophosphatidic acid-induced transport, cytoskeletal organization and migration.
25555354	Prostaglandins Leukot. Essent. Fatty Acids	2015	Block RC et al.	The effects of aspirin on platelet function and lysophosphatidic acids depend on plasma concentrations of EPA and DHA.
25499971	Exp. Cell Res.	2015	Kihara Y et al.	Lysophospholipid receptors in drug discovery.
25464168	Osteoarthr. Cartil.	2015	Wu L et al.	Lysophosphatidic acid mediates fibrosis in injured joints by regulating collagen type I biosynthesis.
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25344254	J. Cell. Sci.	2014	Argenzio E et al.	CLIC4 regulates cell adhesion and β1 integrin trafficking.
25190756	Blood	2014	Hsieh WC et al.	Inability to resolve specific infection generates innate immunodeficiency syndrome in Xiap-/- mice.
24657741	Free Radic. Biol. Med.	2014	Klomsiri C et al.	Endosomal H2O2 production leads to localized cysteine sulfenic acid formation on proteins during lysophosphatidic acid-mediated cell signaling.
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24445011	J. Formos. Med. Assoc.	2014	Wang CY et al.	Epigallocatechin-3-gallate inhibits lysophosphatidic acid-stimulated connective tissue growth factor via JNK and Smad3 suppression in human gingival fibroblasts.