stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

References related to genes published in Others

PMID	Journal	Published Date	Author	Title
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12663471	Diabetes	2003	Eitel K et al.	Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells.
12671095	Plant Cell	2003	Bonaventure G et al.	Disruption of the FATB gene in Arabidopsis demonstrates an essential role of saturated fatty acids in plant growth.
12606504	Diabetes	2003	Weigert C et al.	Palmitate-induced activation of the hexosamine pathway in human myotubes: increased expression of glutamine:fructose-6-phosphate aminotransferase.
10584037	Am. J. Clin. Nutr.	1999	Connor WE	Harbingers of coronary heart disease: dietary saturated fatty acids and cholesterol. Is chocolate benign because of its stearic acid content?
9761789	Plant Cell	1998	Merlo AO et al.	Ribozymes targeted to stearoyl-ACP delta9 desaturase mRNA produce heritable increases of stearic acid in transgenic maize leaves.
14652360	J. Nutr.	2003	Baer DJ et al.	Stearic acid absorption and its metabolizable energy value are minimally lower than those of other fatty acids in healthy men fed mixed diets.
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17056791	J. Nutr.	2006	Rasmussen HE et al.	Reduction in cholesterol absorption is enhanced by stearate-enriched plant sterol esters in hamsters.
22556332	Arterioscler. Thromb. Vasc. Biol.	2012	Anderson EK et al.	Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.
23362303	Circ Cardiovasc Genet	2013	Wu JH et al.	Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
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20841452	Plant Physiol.	2010	Do PT et al.	The influence of fruit load on the tomato pericarp metabolome in a Solanum chmielewskii introgression line population.
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22679004	Am. J. Physiol. Gastrointest. Liver Physiol.	2012	Bederman I et al.	Altered de novo lipogenesis contributes to low adipose stores in cystic fibrosis mice.
21378177	Diabetes	2011	Nicholls HT et al.	Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue.
19651814	Diabetes	2009	Kantartzis K et al.	Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene.
19478146	Diabetes	2009	Peter A et al.	Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo.
18718999	Am. J. Physiol. Gastrointest. Liver Physiol.	2008	Labonté ED et al.	Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice.
18633101	Diabetes	2008	Reyna SM et al.	Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects.
26711260	Mol. Cell. Biol.	2015	Doignon F et al.	Requirement of Phosphoinositides Containing Stearic Acid To Control Cell Polarity.
25527759	Am. J. Clin. Nutr.	2015	Ma W et al.	Prospective association of fatty acids in the de novo lipogenesis pathway with risk of type 2 diabetes: the Cardiovascular Health Study.