Ganglioside GM2

Ganglioside GM2 is a lipid of Sphingolipids (SP) class. Ganglioside gm2 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Autoimmune Diseases, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating and Neuromuscular Diseases. The involved functions are known as Pressure- physical agent, Cytolysis, Inflammation, Complement-Dependent Cytotoxicity and conjugation. Ganglioside gm2 often locates in Membrane, Entire nervous system, Cell surface, Biopsy sample and Lipid Bilayers. The associated genes with Ganglioside GM2 are anti-IgM, Polypeptides, Transgenes, Alleles and Homologous Gene. The related lipids are Ganglioside GA2, QS 21, sulfate-3-glucuronyl paragloboside, Lipopolysaccharides and IV(4)-galactosyl-N-acetylganglioside GD1a. The related experimental models are Disease model.

References related to genes published in Others


PMIDJournalPublished DateAuthorTitle
11358851Cancer Res.2001Yoshida S et al.Ganglioside G(D2) in small cell lung cancer cell lines: enhancement of cell proliferation and mediation of apoptosis.
15993494J. Neuroimmunol.2005Moran AP et al.Antibodies induced by ganglioside-mimicking Campylobacter jejuni lipooligosaccharides recognise epitopes at the nodes of Ranvier.
26175473J. Lipid Res.2015Anheuser S et al.Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity.
25873306ASN NeuroRockwell HE et al.AAV-mediated gene delivery in a feline model of Sandhoff disease corrects lysosomal storage in the central nervous system.
25717099Sci Transl Med2015Vite CH et al.Intracisternal cyclodextrin prevents cerebellar dysfunction and Purkinje cell death in feline Niemann-Pick type C1 disease.
21487393Mol. Ther.2011Matsuoka K et al.Therapeutic potential of intracerebroventricular replacement of modified human β-hexosaminidase B for GM2 gangliosidosis.
20187655ACS Chem. Biol.2010Ho CW et al.Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.
19559406
18241673Clin. Biochem.2008Gu J et al.Simultaneous quantification of GM1 and GM2 gangliosides by isotope dilution tandem mass spectrometry.
17915254J. Neurol. Sci.2008Nobile-Orazio E et al.How useful are anti-neural IgM antibodies in the diagnosis of chronic immune-mediated neuropathies?
17253773Biochemistry2007Martinez Z et al.GM1 specifically interacts with alpha-synuclein and inhibits fibrillation.
17198760J. Feline Med. Surg.2007Hasegawa D et al.Clinical and molecular analysis of GM2 gangliosidosis in two apparent littermate kittens of the Japanese domestic cat.
16962990Arch. Biochem. Biophys.2006Duan J et al.Ganglioside GM2 modulates the erythrocyte Ca2+-ATPase through its binding to the calmodulin-binding domain and its 'receptor'.
16707183J. Biotechnol.2006Thiesen PH et al.Glycolipids from a colloid chemical point of view.
16620986Mol. Immunol.2007López-Requena A et al.Gangliosides, Ab1 and Ab2 antibodies II. Light versus heavy chain: An idiotype-anti-idiotype case study.
16478472FEBS J.2006Wendeler M et al.The enzyme-binding region of human GM2-activator protein.
12705795Intern. Med.2003Mizutani K et al.Amyotrophic lateral sclerosis with IgM antibody against gangliosides GM2 and GD2.
11578853Brain Dev.2001Taniguchi M et al.Sites and temporal changes of gangliosides GM1/GM2 storage in the Niemann-Pick disease type C mouse brain.
11064828Clin Rev Allergy Immunol2000Portoukalian JImmunogenicity of glycolipids.
10704706Lung Cancer2000Brezicka T et al.Reactivity of monoclonal antibodies with ganglioside antigens in human small cell lung cancer tissues.
10571007Biochim. Biophys. Acta1999Mahuran DJBiochemical consequences of mutations causing the GM2 gangliosidoses.
10529115Microbiol. Immunol.1999Okada N et al.Human IgM monoclonal antibody to ganglioside GM2 and complement suppress virus propagation in ex vivo cultures of lymphocytes from HIV-1 infected patients.
10073593J. Am. Soc. Nephrol.1999Mundel TM et al.Ganglioside GM2-activator protein and vesicular transport in collecting duct intercalated cells.
9972876Neurochem. Res.1999Usuki S et al.GM2 promotes ciliary neurotrophic factor-dependent rescue of immortalized motor neuron-like cell (NSC-34).
9728970J. Neurol. Neurosurg. Psychiatry1998Tsukaguchi M et al.IgM anti-GM2 antibody in a patient with Guillain-Barré syndrome subsequent to cytomegalovirus hepatitis cross reacts with N-acetylgalactosaminyl GD1a.
9668352Ann. N. Y. Acad. Sci.1998Walkley SU et al.GM2 ganglioside as a regulator of pyramidal neuron dendritogenesis.
9572057Mol Med Today1998Chavany C and Jendoubi MBiology and potential strategies for the treatment of GM2 gangliosidoses.
9435988Clin. Chim. Acta1997Sandhoff K and Kolter TBiochemistry of glycosphingolipid degradation.
8544979Neuroscience1995Walkley SUPyramidal neurons with ectopic dendrites in storage diseases exhibit increased GM2 ganglioside immunoreactivity.
1291049Carbohydr. Res.1992Schaeper RJ et al.In vitro biosynthesis of GbOse4Cer (globoside) and GM2 ganglioside by the (1-->3) and (1-->4)-N-acetyl beta-D-galactosaminyltransferases from embryonic chicken brain. Solubilization, purification, and characterization of the transferases.
2977954Br J Psychiatry1988Lichtenberg P et al.Post-partum psychosis in adult GM2 gangliosidosis. A case report.