Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
References related to lipids published in Others
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 6696992 | Blood | 1984 | Hoffman DR et al. | Cytotoxicity of platelet activating factor and related alkyl-phospholipid analogs in human leukemia cells, polymorphonuclear neutrophils, and skin fibroblasts. |
| 9445250 | Arterioscler. Thromb. Vasc. Biol. | 1998 | Nilsson J et al. | Lipoprotein-like phospholipid particles inhibit the smooth muscle cell cytotoxicity of lysophosphatidylcholine and platelet-activating factor. |
| 9437199 | Arterioscler. Thromb. Vasc. Biol. | 1997 | Tsoukatos DC et al. | Copper-catalyzed oxidation mediates PAF formation in human LDL subspecies. Protective role of PAF:acetylhydrolase in dense LDL. |
| 9122237 | Proc. Natl. Acad. Sci. U.S.A. | 1997 | Xia D and Samols D | Transgenic mice expressing rabbit C-reactive protein are resistant to endotoxemia. |
| 9023292 | J. Pharmacol. Exp. Ther. | 1997 | Riera M et al. | Neutrophils accentuate renal cold ischemia-reperfusion injury. Dose-dependent protective effect of a platelet-activating factor receptor antagonist. |
| 11510782 | Eur. Respir. J. | 2001 | Feldman C et al. | Vitamin E attenuates the injurious effects of bioactive phospholipids on human ciliated epithelium in vitro. |
| 12356842 | Invest. Ophthalmol. Vis. Sci. | 2002 | Beauchamp MH et al. | Platelet-activating factor in vasoobliteration of oxygen-induced retinopathy. |
| 9412509 | J. Neurosci. | 1998 | Bix GJ and Clark GD | Platelet-activating factor receptor stimulation disrupts neuronal migration In vitro. |
| 15280540 | Proc. Natl. Acad. Sci. U.S.A. | 2004 | Llodrá J et al. | Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques. |
| 21257713 | FASEB J. | 2011 | Garland RC et al. | Noninvasive molecular imaging reveals role of PAF in leukocyte-endothelial interaction in LPS-induced ocular vascular injury. |
| 18931035 | Mol. Pharmacol. | 2009 | Welch EJ et al. | Opposing effects of platelet-activating factor and lyso-platelet-activating factor on neutrophil and platelet activation. |
| 19773578 | Am. J. Physiol. Endocrinol. Metab. | 2009 | Cheng L et al. | A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice. |
| 18339705 | Am. J. Physiol. Gastrointest. Liver Physiol. | 2008 | Claud EC et al. | Platelet-activating factor-induced chloride channel activation is associated with intracellular acidosis and apoptosis of intestinal epithelial cells. |
| 15778280 | Am. J. Physiol. Heart Circ. Physiol. | 2005 | Minnear FL et al. | Sphingosine 1-phosphate prevents platelet-activating factor-induced increase in hydraulic conductivity in rat mesenteric venules: pertussis toxin sensitive. |
| 16501051 | J. Leukoc. Biol. | 2006 | Flamand N et al. | Inhibition of platelet-activating factor biosynthesis by adenosine and histamine in human neutrophils: involvement of cPLA2alpha and reversal by lyso-PAF. |