trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

References related to lipids published in Others

PMID	Journal	Published Date	Author	Title
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15269190	Drug Metab. Dispos.	2004	Sanderson L et al.	Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.
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18310117	J. Exp. Biol.	2008	Jiang Y et al.	Homocysteine-induced extracellular superoxide dismutase and its epigenetic mechanisms in monocytes.
15557281	J. Biol. Chem.	2005	Varshochi R et al.	ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line.
16234266	Am. J. Physiol. Endocrinol. Metab.	2006	Sato TA and Mitchell MD	Molecular inhibition of histone deacetylation results in major enhancement of the production of IL-1beta in response to LPS.
15930180	J. Endocrinol.	2005	Gunin AG et al.	Effects of histone deacetylase inhibitors on estradiol-induced proliferation and hyperplasia formation in the mouse uterus.
16513842	Mol. Cancer Res.	2006	Rokhlin OW et al.	Mechanisms of cell death induced by histone deacetylase inhibitors in androgen receptor-positive prostate cancer cells.
18451057	Microbiology (Reading, Engl.)	2008	van West P et al.	Internuclear gene silencing in Phytophthora infestans is established through chromatin remodelling.
22955928	Blood	2012	Sadoul K et al.	HDAC6 controls the kinetics of platelet activation.
22693257	J. Lipid Res.	2012	Nunes MJ et al.	Okadaic acid inhibits the trichostatin A-mediated increase of human CYP46A1 neuronal expression in a ERK1/2-Sp3-dependent pathway.