rotenone

rotenone is a lipid of Polyketides (PK) class. Rotenone is associated with abnormalities such as Parkinson Disease, MYOPATHY, DISTAL, WITH ANTERIOR TIBIAL ONSET, Neurodegenerative Disorders, Septicemia and Respiratory Failure. The involved functions are known as Phosphorylation, Process, Cell Death, proteasome activity and Apoptosis. Rotenone often locates in Protoplasm, Presynaptic Terminals, Neurites, NADH dehydrogenase complex and Mitochondria. The associated genes with rotenone are DNAJB9 gene, EIF2S3 gene, Candidate Disease Gene, G-substrate and ERN1 gene. The related lipids are Lipopolysaccharides, Membrane Lipids, Phosphatidylserines, Fatty Acids and Cardiolipins. The related experimental models are Knock-out, Mouse Model, Disease model and Rodent Model.

References related to lipids published in Others

PMID	Journal	Published Date	Author	Title
10022826	EMBO J.	1999	Liss B et al.	Alternative sulfonylurea receptor expression defines metabolic sensitivity of K-ATP channels in dopaminergic midbrain neurons.
12151355	Carcinogenesis	2002	Tanaka T et al.	Modifying effects of dietary capsaicin and rotenone on 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
12952856	Am. J. Physiol. Renal Physiol.	2003	Zager RA et al.	Proximal tubular cholesterol loading after mitochondrial, but not glycolytic, blockade.
21300668	Hypertension	2011	Rowlands DJ et al.	Equol-stimulated mitochondrial reactive oxygen species activate endothelial nitric oxide synthase and redox signaling in endothelial cells: roles for F-actin and GPR30.
20100866	Mol. Cell. Biol.	2010	Fogal V et al.	Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation.
17671207	Cancer Res.	2007	Lluis JM et al.	Dual role of mitochondrial reactive oxygen species in hypoxia signaling: activation of nuclear factor-{kappa}B via c-SRC and oxidant-dependent cell death.
25263579	Exp. Neurol.	2015	Chiu CC et al.	Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism.
24120951	Parkinsonism Relat. Disord.	2014	Kamel F et al.	Dietary fat intake, pesticide use, and Parkinson's disease.
25155595	Antimicrob. Agents Chemother.	2014	Mesa-Arango AC et al.	The production of reactive oxygen species is a universal action mechanism of Amphotericin B against pathogenic yeasts and contributes to the fungicidal effect of this drug.
24965893	Neurobiol. Dis.	2014	Hwang RD et al.	The neuroprotective effect of human uncoupling protein 2 (hUCP2) requires cAMP-dependent protein kinase in a toxin model of Parkinson's disease.