quercetin

quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.

References related to lipids published in Others

PMID	Journal	Published Date	Author	Title
8576124	J. Biol. Chem.	1996	Zhu BT and Liehr JG	Inhibition of catechol O-methyltransferase-catalyzed O-methylation of 2- and 4-hydroxyestradiol by quercetin. Possible role in estradiol-induced tumorigenesis.
9409251	Arterioscler. Thromb. Vasc. Biol.	1997	Hayek T et al.	Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation.
11722907	Appl. Environ. Microbiol.	2001	Braune A et al.	Degradation of quercetin and luteolin by Eubacterium ramulus.
10564243	Am. J. Physiol.	1999	Rangan GK et al.	Inhibition of NFkappaB activation with antioxidants is correlated with reduced cytokine transcription in PTC.
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14633740	Cancer Res.	2003	Schwarz D et al.	St. John's wort extracts and some of their constituents potently inhibit ultimate carcinogen formation from benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1.
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15155557	Drug Metab. Dispos.	2004	Walsky RL and Obach RS	Validated assays for human cytochrome P450 activities.
14688022	Carcinogenesis	2004	Nguyen TT et al.	The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells.
21602180	Nephrol. Dial. Transplant.	2011	Sanchez-Gonzalez PD et al.	Quercetin reduces cisplatin nephrotoxicity in rats without compromising its anti-tumour activity.
19265134	J. Immunol.	2009	Capini C et al.	Antigen-specific suppression of inflammatory arthritis using liposomes.
19605544	Am. J. Physiol. Renal Physiol.	2009	Hu QH et al.	Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvement.
17332522	J. Endocrinol.	2007	Chen YC et al.	Effects of genistein, resveratrol, and quercetin on steroidogenesis and proliferation of MA-10 mouse Leydig tumor cells.
17548901	Carcinogenesis	2007	Rubio S et al.	Acetyl derivative of quercetin 3-methyl ether-induced cell death in human leukemia cells is amplified by the inhibition of ERK.
18032389	J. Biol. Chem.	2008	Soundararajan R et al.	Quercetin 3-glucoside protects neuroblastoma (SH-SY5Y) cells in vitro against oxidative damage by inducing sterol regulatory element-binding protein-2-mediated cholesterol biosynthesis.
17876056	Mol. Cancer Ther.	2007	Psahoulia FH et al.	Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts.
14982785	Antimicrob. Agents Chemother.	2004	Mamani-Matsuda M et al.	Quercetin induces apoptosis of Trypanosoma brucei gambiense and decreases the proinflammatory response of human macrophages.
15044614	Mol. Pharmacol.	2004	López-López G et al.	Nitric oxide (NO) scavenging and NO protecting effects of quercetin and their biological significance in vascular smooth muscle.
16455785	Am. J. Physiol. Gastrointest. Liver Physiol.	2006	Mutch DM et al.	Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.
17092984	Mol. Hum. Reprod.	2007	Biondi C et al.	Expression and characterization of vitamin C transporter in the human trophoblast cell line HTR-8/SVneo: effect of steroids, flavonoids and NSAIDs.
17135264	J. Biol. Chem.	2007	Ferrer P et al.	Nitric oxide mediates natural polyphenol-induced Bcl-2 down-regulation and activation of cell death in metastatic B16 melanoma.
18628248	Carcinogenesis	2008	Lin CW et al.	Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells.
18633129	Blood	2008	Liu FT et al.	Dietary flavonoids inhibit the anticancer effects of the proteasome inhibitor bortezomib.
22332099	Adv Nutr	2012	Larson AJ et al.	Therapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanisms.
23197198	Toxicol Pathol	2013	Vásquez-Garzón VR et al.	The chemopreventive capacity of quercetin to induce programmed cell death in hepatocarcinogenesis.