Prostaglandin E2

Prostaglandin E2 is a lipid of Fatty Acyls (FA) class. Prostaglandin e2 is associated with abnormalities such as Renal glomerular disease, Arthritis, Degenerative polyarthritis, Pancreatitis and Rheumatoid Arthritis. The involved functions are known as enzyme pathway, Atherogenesis, Anabolism, inhibitors and Oxidants. Prostaglandin e2 often locates in Tissue membrane, Blood, Extracellular, Membrane and Protoplasm. The associated genes with Prostaglandin E2 are PTGS2 gene, TP53 gene, TNFRSF5 gene, FASTK Gene and TNF gene. The related lipids are Lipopolysaccharides, Steroids, monooxyethylene trimethylolpropane tristearate, Fatty Acids, Unsaturated and Promega. The related experimental models are Arthritis, Adjuvant-Induced, Xenograft Model, Experimental Autoimmune Encephalomyelitis, Cancer Model and Knock-out.

References related to lipids published in Others

PMID	Journal	Published Date	Author	Title
26906248	J. Pharmacol. Sci.	2016	Sugita R et al.	A novel selective prostaglandin E2 synthesis inhibitor relieves pyrexia and arthritis in Guinea pigs inflammatory models.
19671757	Mol. Cancer Ther.	2009	Koeberle A et al.	Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1.
21896757	Proc. Natl. Acad. Sci. U.S.A.	2011	Clasadonte J et al.	Prostaglandin E2 release from astrocytes triggers gonadotropin-releasing hormone (GnRH) neuron firing via EP2 receptor activation.
18583546	J. Pharmacol. Exp. Ther.	2008	Yu L et al.	E series of prostaglandin receptor 2-mediated activation of extracellular signal-regulated kinase/activator protein-1 signaling is required for the mitogenic action of prostaglandin E2 in esophageal squamous-cell carcinoma.
16931794	Arterioscler. Thromb. Vasc. Biol.	2006	Clavreul N et al.	S-glutathiolation of p21ras by peroxynitrite mediates endothelial insulin resistance caused by oxidized low-density lipoprotein.
12970137	Gut	2003	Willemsen LE et al.	Short chain fatty acids stimulate epithelial mucin 2 expression through differential effects on prostaglandin E(1) and E(2) production by intestinal myofibroblasts.
25595355	Theriogenology	2015	Kowalewski MP et al.	Formation of the early canine CL and the role of prostaglandin E2 (PGE2) in regulation of its function: an in vivo approach.
20335389	Mol. Pharmacol.	2010	Ji R et al.	EP1 prostanoid receptor coupling to G i/o up-regulates the expression of hypoxia-inducible factor-1 alpha through activation of a phosphoinositide-3 kinase signaling pathway.
16777358	Toxicol. Lett.	2006	Seok SM et al.	COX-2 is associated with cadmium-induced ICAM-1 expression in cerebrovascular endothelial cells.
16644903	J. Pharmacol. Exp. Ther.	2006	Claudino RF et al.	Pharmacological and molecular characterization of the mechanisms involved in prostaglandin E2-induced mouse paw edema.
15491851	Nitric Oxide	2004	Jones CP et al.	Prostaglandin E2 and dexamethasone regulate eosinophil differentiation and survival through a nitric oxide- and CD95-dependent pathway.
15234114	Neurochem. Int.	2004	Takadera T et al.	Prostaglandin E2 induced caspase-dependent apoptosis possibly through activation of EP2 receptors in cultured hippocampal neurons.
12757841	Life Sci.	2003	Kim SS et al.	Eugenol suppresses cyclooxygenase-2 expression in lipopolysaccharide-stimulated mouse macrophage RAW264.7 cells.
29046334	EMBO J.	2017	Sabirov RZ et al.	The organic anion transporter SLCO2A1 constitutes the core component of the Maxi-Cl channel.
28637666	Blood	2017	Prince LR et al.	NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival.
27912907	Bioorg. Chem.	2017	Lee SR et al.	Bioactivity-guided isolation of anti-inflammatory triterpenoids from the sclerotia of Poria cocos using LPS-stimulated Raw264.7 cells.
27871670	Biol. Psychiatry	2017	McCarthy MM and Wright CL	Convergence of Sex Differences and the Neuroimmune System in Autism Spectrum Disorder.
27745800	J Chin Med Assoc	2017	Kansu-Celik H et al.	Prostaglandin E2 induction of labor and cervical ripening for term isolated oligohydramnios in pregnant women with Bishop score ≤ 5.
27616330	Biochim. Biophys. Acta	2016	Filipenko I et al.	Upregulation of the S1P3 receptor in metastatic breast cancer cells increases migration and invasion by induction of PGE2 and EP2/EP4 activation.
27292189	Cell Stem Cell	2016	Schewe M et al.	Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer.
27180879	J Ethnopharmacol	2016	Lee CW et al.	Eupafolin ameliorates COX-2 expression and PGE2 production in particulate pollutants-exposed human keratinocytes through ROS/MAPKs pathways.
27105159	Atherosclerosis	2016	Santilli F et al.	The Coxib case: Are EP receptors really guilty?
26932930	FASEB J.	2016	Chan PC et al.	Importance of adipocyte cyclooxygenase-2 and prostaglandin E2-prostaglandin E receptor 3 signaling in the development of obesity-induced adipose tissue inflammation and insulin resistance.
26631441	Bioorg. Med. Chem.	2015	Cho NC et al.	Discovery of 2-aryloxy-4-amino-quinazoline derivatives as novel protease-activated receptor 2 (PAR2) antagonists.
26571085	J Ethnopharmacol	2016	Yu Y et al.	DXXK exerts anti-inflammatory effects by inhibiting the lipopolysaccharide-induced NF-κB/COX-2 signalling pathway and the expression of inflammatory mediators.
26320551	Brain Res.	2015	Mizutani Y et al.	Effects of prostaglandin E2 on synaptic transmission in the rat spinal trigeminal subnucleus caudalis.
26253311	Med. Hypotheses	2015	Foster J et al.	Is prostaglandin E2 (PGE2) involved in the thermogenic response to environmental cooling in healthy humans?
26077962	Thromb. Res.	2015	Friedman EA et al.	Understanding the role of prostaglandin E2 in regulating human platelet activity in health and disease.
25916550	Cell Res.	2015	Li P et al.	Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment.
25634334	Carcinogenesis	2015	Nakanishi M et al.	Non-cell autonomous effects of targeting inducible PGE2 synthesis during inflammation-associated colon carcinogenesis.
25184246	Am J Sports Med	2014	Dolkart O et al.	Statins enhance rotator cuff healing by stimulating the COX2/PGE2/EP4 pathway: an in vivo and in vitro study.
25122761	J. Biol. Chem.	2014	Shridas P et al.	Group X secretory phospholipase A2 regulates insulin secretion through a cyclooxygenase-2-dependent mechanism.
24861422	J. Neurosci. Methods	2014	Gruen M et al.	Use of dynamic weight bearing as a novel end-point for the assessment of abdominal pain in the LPS-induced peritonitis model in the rat.
24853621	J Ethnopharmacol	2014	Ni LJ et al.	Quantitative evaluation of the in vitro effect and interactions of active fractions in Yaotongning-based formulae on prostaglandin E₂ production.
24455777	Int. Immunopharmacol.	2013	Zhang YX et al.	Ginsenoside-Rd exhibits anti-inflammatory activities through elevation of antioxidant enzyme activities and inhibition of JNK and ERK activation in vivo.
24338998	Mol Nutr Food Res	2014	Kim MS et al.	Phloretin suppresses thrombin-mediated leukocyte-platelet-endothelial interactions.
23817085	Lab. Invest.	2013	Mohamed R et al.	Chronic administration of EP4-selective agonist exacerbates albuminuria and fibrosis of the kidney in streptozotocin-induced diabetic mice through IL-6.
23796953	Trends Pharmacol. Sci.	2013	Jiang J and Dingledine R	Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection.
23630358	J. Immunol.	2013	Domingo-Gonzalez R et al.	Prostaglandin E2-induced changes in alveolar macrophage scavenger receptor profiles differentially alter phagocytosis of Pseudomonas aeruginosa and Staphylococcus aureus post-bone marrow transplant.
23439561	Mol. Pharmacol.	2013	Zhou X et al.	NADPH oxidase NOX5-S and nuclear factor κB1 mediate acid-induced microsomal prostaglandin E synthase-1 expression in Barrett's esophageal adenocarcinoma cells.
23419768	Prostaglandins Leukot. Essent. Fatty Acids	2013	Jones RL et al.	Nature of the slow relaxation of smooth muscle induced by a EP2 receptor agonist with a non-prostanoid structure.
23200567	J. Neuroimmunol.	2013	Liu M et al.	Immunoregulation of myelin-specific CD4+ T cell response by neural stem/progenitor cells: role of prostaglandin E2.
22914655	J. Neurophysiol.	2012	Alvarez P et al.	IB4(+) nociceptors mediate persistent muscle pain induced by GDNF.
22835428	Int. Immunopharmacol.	2012	Wang D et al.	Paeoniflorin inhibits function and down-regulates HLA-DR and CD80 expression of human peripheral blood monocytes stimulated by rhIL-1β.
22566780	ScientificWorldJournal	2012	Hamed MA et al.	Therapeutic potential of ginger against renal injury induced by carbon tetrachloride in rats.
21519044	Anesth. Analg.	2011	Kohno T	Zaltoprofen inhibits bradykinin-mediated enhancement of glutamate receptor activity in substantia gelatinosa neurons.
20553183	J Med Food	2010	Choi SY et al.	Isolation and anti-inflammatory activity of Bakuchiol from Ulmus davidiana var. japonica.
20079660	Trends Endocrinol. Metab.	2010	Blackwell KA et al.	Prostaglandins in bone: bad cop, good cop?
19455748	Biochimie	2009	Calder PC	Polyunsaturated fatty acids and inflammatory processes: New twists in an old tale.
18472001	Clin. Biochem.	2008	Kardeşler L et al.	Gingival crevicular fluid PGE2, IL-1beta, t-PA, PAI-2 levels in type 2 diabetes and relationship with periodontal disease.
16616083	Fertil. Steril.	2006	Wang H et al.	Regulation of cyclooxygenase activity in cultured endometrial stromal cells by granulocyte-macrophage colony-stimulating factor.
16337130	Bioorg. Med. Chem.	2006	Reyes CP et al.	Activity of lupane triterpenoids from Maytenus species as inhibitors of nitric oxide and prostaglandin E2.
16297708	Cancer Lett.	2005	Kang JH et al.	Soybean saponins suppress the release of proinflammatory mediators by LPS-stimulated peritoneal macrophages.