20-HETE
20-hete is a lipid of Fatty Acyls (FA) class. 20-hete is associated with abnormalities such as Cyst, Kidney Diseases, Kidney Failure, Chronic, Cystic Kidney Diseases and Simple renal cyst. The involved functions are known as Phosphorylation, inhibitors, Hypertrophy, Epithelial Cell Proliferation and Anabolism. 20-hete often locates in Mouse Kidney, Microsomes, Tissue membrane, Body tissue and Cytoplasmic matrix. The associated genes with 20-HETE are CYP4F3 gene, PKHD1 gene, Transgenes, P4HTM gene and CYP2E1 gene. The related lipids are Promega, enterodiol, Fatty Acids, hexanoic acid and U 73343. The related experimental models are Mouse Model, Knock-out, Streptozotocin Diabetes, Transgenic Model and Rodent Model.
References related to lipids published in Others
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 9831701 | Circ. Res. | 1998 | Sun CW et al. | Nitric oxide-20-hydroxyeicosatetraenoic acid interaction in the regulation of K+ channel activity and vascular tone in renal arterioles. |
| 11208597 | Am. J. Physiol. Renal Physiol. | 2001 | Gu R et al. | Role of 20-HETE in mediating the effect of dietary K intake on the apical K channels in the mTAL. |
| 12069931 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | 2002 | Alonso-Galicia M et al. | Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin II. |
| 12060587 | Am. J. Physiol. Renal Physiol. | 2002 | Marji JS et al. | Cytochrome P-450 4A isoform expression and 20-HETE synthesis in renal preglomerular arteries. |
| 12235040 | J. Appl. Physiol. | 2002 | Yu M et al. | Nitric oxide contributes to 20-HETE-induced relaxation of pulmonary arteries. |
| 12794071 | J. Biol. Chem. | 2003 | Basora N et al. | 20-hydroxyeicosatetraenoic acid (20-HETE) activates mouse TRPC6 channels expressed in HEK293 cells. |
| 12754190 | Am. J. Physiol. Lung Cell Mol. Physiol. | 2003 | Cloutier M et al. | 20-HETE inotropic effects involve the activation of a nonselective cationic current in airway smooth muscle. |
| 10966934 | Am. J. Physiol. Renal Physiol. | 2000 | Croft KD et al. | Angiotensin II releases 20-HETE from rat renal microvessels. |
| 10884373 | Circ. Res. | 2000 | Gebremedhin D et al. | Production of 20-HETE and its role in autoregulation of cerebral blood flow. |
| 14612451 | J. Biol. Chem. | 2004 | Kaduce TL et al. | 20-hydroxyeicosatetraenoic acid (20-HETE) metabolism in coronary endothelial cells. |
| 17303679 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | 2007 | Yu M et al. | Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle. |
| 15831442 | J. Pharmacol. Exp. Ther. | 2005 | Miyata N et al. | Beneficial effects of a new 20-hydroxyeicosatetraenoic acid synthesis inhibitor, TS-011 [N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamide], on hemorrhagic and ischemic stroke. |
| 15639488 | Cardiovasc. Res. | 2005 | Randriamboavonjy V et al. | The synthesis of 20-HETE in small porcine coronary arteries antagonizes EDHF-mediated relaxation. |
| 16081420 | J. Biol. Chem. | 2005 | Collins XH et al. | Omega-oxidation of 20-hydroxyeicosatetraenoic acid (20-HETE) in cerebral microvascular smooth muscle and endothelium by alcohol dehydrogenase 4. |
| 16775295 | AJNR Am J Neuroradiol | 2006 Jun-Jul | Hacein-Bey L et al. | Reversal of delayed vasospasm by TS-011 in the dual hemorrhage dog model of subarachnoid hemorrhage. |
| 16679379 | Am. J. Physiol. Lung Cell Mol. Physiol. | 2006 | Jacobs ER et al. | VEGF-induced relaxation of pulmonary arteries is mediated by endothelial cytochrome P-450 hydroxylase. |
| 18725506 | Drug Metab. Dispos. | 2008 | Mu Y et al. | Intravenous formulation of N-hydroxy-N'-(4-n-butyl-2-methylphenyl)formamidine (HET0016) for inhibition of rat brain 20-hydroxyeicosatetraenoic acid formation. |
| 17916879 | J. Lipid Res. | 2008 | Liang CJ et al. | 20-HETE inhibits the proliferation of vascular smooth muscle cells via transforming growth factor-beta. |
| 23966667 | J. Lipid Res. | 2013 | Van Bogaert I et al. | Preparation of 20-HETE using multifunctional enzyme type 2-negative Starmerella bombicola. |
| 26895643 | Am. J. Physiol. Lung Cell Mol. Physiol. | 2016 | Kizub IV et al. | Involvement of gap junctions between smooth muscle cells in sustained hypoxic pulmonary vasoconstriction development: a potential role for 15-HETE and 20-HETE. |